2014
Engineering Human Peripheral Blood Stem Cell Grafts that Are Depleted of Naïve T Cells and Retain Functional Pathogen-Specific Memory T Cells
Bleakley M, Heimfeld S, Jones LA, Turtle C, Krause D, Riddell SR, Shlomchik W. Engineering Human Peripheral Blood Stem Cell Grafts that Are Depleted of Naïve T Cells and Retain Functional Pathogen-Specific Memory T Cells. Transplantation And Cellular Therapy 2014, 20: 705-716. PMID: 24525279, PMCID: PMC3985542, DOI: 10.1016/j.bbmt.2014.01.032.Peer-Reviewed Original ResearchConceptsPeripheral blood stem cellsHematopoietic cell transplantationMemory T cellsStem cell graftsT cellsCell graftsPathogen-specific memory T cellsPeripheral blood stem cell graftsAllogeneic stem cell graftsBlood stem cell graftsNaïve T cell subsetsAllogeneic hematopoietic cell transplantationFrequent major complicationCentral memory phenotypeT cell subsetsBlood stem cellsNaïve T cellsOpportunistic pathogenCommon opportunistic pathogenStem cellsHost diseaseHCT outcomesEffector cytokinesMajor complicationsMemory phenotype
2007
Bone Marrow Contributes to Epithelial Cancers in Mice and Humans as Developmental Mimicry
Cogle CR, Theise ND, Fu D, Ucar D, Lee S, Guthrie SM, Lonergan J, Rybka W, Krause DS, Scott EW. Bone Marrow Contributes to Epithelial Cancers in Mice and Humans as Developmental Mimicry. Stem Cells 2007, 25: 1881-1887. PMID: 17478582, DOI: 10.1634/stemcells.2007-0163.Peer-Reviewed Original ResearchConceptsEpithelial cancersEpithelial neoplasiaHematopoietic stem cellsNeoplastic environmentStem cellsHematopoietic cell transplantationBone marrow cellsHuman marrowMarrow involvementMarrow cellsSmall bowelCell transplantationLung neoplasiaMouse modelBone marrowMimicryDistant organsNeoplasiaCancerMarrowStable fusionCellsPhenotypeInductionBowel