2023
Tackling FGFR3-driven bladder cancer with a promising synergistic FGFR/HDAC targeted therapy
Wang Z, Muthusamy V, Petrylak D, Anderson K. Tackling FGFR3-driven bladder cancer with a promising synergistic FGFR/HDAC targeted therapy. Npj Precision Oncology 2023, 7: 70. PMID: 37479885, PMCID: PMC10362036, DOI: 10.1038/s41698-023-00417-5.Peer-Reviewed Original ResearchBladder cancerBC cellsEarly phase clinical trialsPhase clinical trialsDurable responsesMetastatic diseaseMost patientsFGFR3 alterationsPrevalent malignancyClinical trialsFGFR3 fusionsPreclinical studiesFGFR inhibitorsHDAC inhibitorsFGFR3 expressionEfficient therapyTherapyCancerQuisinostatFGFR3New mechanistic insightsInhibitorsCellsPatientsMalignancy
2020
BT8009-100 phase I/II study of the safety, pharmacokinetics, & preliminary clinical activity of BT8009 in patients with Nectin-4 expressing advanced malignancies
Mckean M, Bendell J, Petrylak D, Powles T, Sonpavde G, Dickson A, Dosunmu L, Hennessy M, Jeffrey P, Rigby M, West T. BT8009-100 phase I/II study of the safety, pharmacokinetics, & preliminary clinical activity of BT8009 in patients with Nectin-4 expressing advanced malignancies. Annals Of Oncology 2020, 31: s500-s501. DOI: 10.1016/j.annonc.2020.08.713.Peer-Reviewed Original Research
2001
Cure of undifferentiated small cell carcinoma of the urinary bladder with M-VAC chemotherapy
Nejat R, Purohit R, Goluboff E, Petrylak D, Rubin M, Benson M. Cure of undifferentiated small cell carcinoma of the urinary bladder with M-VAC chemotherapy. Urologic Oncology Seminars And Original Investigations 2001, 6: 53-55. PMID: 11166621, DOI: 10.1016/s1078-1439(00)00098-3.Peer-Reviewed Original ResearchSmall cell carcinomaUrinary bladderCell carcinomaUndifferentiated small cell carcinomaM-VAC chemotherapyRecurrence 3 yearsRadical surgeryPathologic evidenceRadical cystoprostatectomyCisplatin chemotherapyAggressive malignancyApparent cureChemotherapyBladderCarcinomaCureCystectomyCystoprostatectomyPatientsSurgeryMalignancyRadiotherapyTumorsAdriamycin