2000
Kinetics and control of oxidative phosphorylation in rat liver mitochondria after chronic ethanol feeding.
Marcinkeviciute A, Mildaziene V, Crumm S, Demin O, Hoek J, Kholodenko B. Kinetics and control of oxidative phosphorylation in rat liver mitochondria after chronic ethanol feeding. Biochemical Journal 2000, 349: 519-26. PMID: 10880351, PMCID: PMC1221175, DOI: 10.1042/0264-6021:3490519.Peer-Reviewed Original ResearchConceptsOxidative phosphorylationRespiratory fluxMitochondrial proton leakRat liver mitochondriaMitochondrial oxidative phosphorylationCytochrome c oxidaseMitochondrial energy metabolismATP synthaseLiver mitochondriaProton leakC oxidaseProtonmotive forceState 3Blocks of reactionsPhosphorylationEnergy metabolismMitochondriaMitochondrial malfunctioningRespiration rateRespiratory activityRespiratory subsystemIndividual functional unitsFunctional unitsKinetics and control of oxidative phosphorylation in rat liver mitochondria after chronic ethanol feeding
MARCINKEVICIUTE A, MILDAZIENE V, CRUMM S, DEMIN O, HOEK J, KHOLODENKO B. Kinetics and control of oxidative phosphorylation in rat liver mitochondria after chronic ethanol feeding. Biochemical Journal 2000, 349: 519-526. DOI: 10.1042/bj3490519.Peer-Reviewed Original ResearchOxidative phosphorylationRespiratory fluxMitochondrial proton leakRat liver mitochondriaMitochondrial oxidative phosphorylationCytochrome c oxidaseMitochondrial energy metabolismATP synthaseLiver mitochondriaBc1 complexProton leakC oxidaseProtonmotive forceState 3PhosphorylationBlocks of reactionsEnergy metabolismMitochondriaMitochondrial malfunctioningRespiration rateRespiratory activityRespiratory subsystemIndividual functional unitsFunctional unitsLow activity
1996
Ca2+ stimulates both the respiratory and phosphorylation subsystems in rat heart mitochondria
MILDAZIENE V, BANIENE R, NAUCIENE Z, MARCINKEVICIUTE A, MORKUNIENE R, BORUTAITE V, KHOLODENKO B, BROWN G. Ca2+ stimulates both the respiratory and phosphorylation subsystems in rat heart mitochondria. Biochemical Journal 1996, 320: 329-334. PMID: 8947505, PMCID: PMC1217935, DOI: 10.1042/bj3200329.Peer-Reviewed Original ResearchConceptsPhosphorylation systemPhosphorylation subsystemProton leakRat heart mitochondriaMitochondrial membrane potentialHeart mitochondriaIsolated rat heart mitochondriaOxidative phosphorylationRespiratory chainMitochondrial respirationStimulation of respirationSuccinate oxidationMembrane potentialPhosphorylationMitochondriaRespiration rateRespirationPhysiological concentrationsRespiratory subsystemState 3Ca2Free Ca2
1995
Calcium Indirectly Increases the Control Exerted by the Adenine Nucleotide Translocator over 2-Oxoglutarate Oxidation in Rat Heart Mitochondria
Mildaziene V, Baniene R, Nauciene Z, Bakker B, Brown G, Westerhoff H, Kholodenko B. Calcium Indirectly Increases the Control Exerted by the Adenine Nucleotide Translocator over 2-Oxoglutarate Oxidation in Rat Heart Mitochondria. Archives Of Biochemistry And Biophysics 1995, 324: 130-134. PMID: 7503547, DOI: 10.1006/abbi.1995.9918.Peer-Reviewed Original Research
1993
The function of ATP/ADP translocator in the regulation of mitochondrial respiration during development of heart ischemic injury
Borutaité V, Mildažiene V, Katiliūté Z, Kholodenko B, Toleikis A. The function of ATP/ADP translocator in the regulation of mitochondrial respiration during development of heart ischemic injury. Biochimica Et Biophysica Acta 1993, 1142: 175-180. PMID: 8457582, DOI: 10.1016/0005-2728(93)90099-2.Peer-Reviewed Original ResearchConceptsATP/ADP translocatorHeart ischemic injuryNormal mitochondriaInhibitor titration studiesRate of succinateIschemic injuryMin ischemiaMitochondrial respiratory rateRespiratory rateOxidative phosphorylationTranslocatorMitochondrial respirationMalate oxidationMitochondriaState 3Heart mitochondriaTotal ischemiaControl coefficientsIschemiaState 4RegulationIschemic mitochondriaInjuryPhosphorylationMaximal rate
1991
Regulation of the heart mitochondrial respiration rate. Comparison of oxidation of succinate and NAD-dependent substrates.
Kholodenko B, Millazhane V, Borutaĭte V, Ivanovene L, Iuodkaĭte R, Katiliute Z, Toleĭkis A. Regulation of the heart mitochondrial respiration rate. Comparison of oxidation of succinate and NAD-dependent substrates. Биохимия 1991, 56: 1420-8. PMID: 1782265.Peer-Reviewed Original ResearchConceptsAdenine nucleotide translocatorNAD-dependent substratesSame relative rateInner mitochondrial membraneProton leakageMitochondrial respiration rateState 4Mitochondrial processesExtramitochondrial adenine nucleotidesMitochondrial membraneState 3Nucleotide translocatorRegulation of respirationRate of respirationSuccinate dehydrogenaseSuccinate oxidationHeart mitochondriaMembrane potentialRespirationRelative ratesRespiration rateMaximal rateRegulationControl of respirationControl coefficients
1989
The role of long-chain acyl-CoA in the disturbances of oxidative phosphorylation in the myocardium.
Borutaĭte V, Mildazhene V, Ivanovene L, Kholodenko B, Toleĭkis A, Prashkiavichius A. The role of long-chain acyl-CoA in the disturbances of oxidative phosphorylation in the myocardium. Биохимия 1989, 54: 1947-51. PMID: 2633800.Peer-Reviewed Original Research
1988
The role of adenine nucleotide translocator in the regulation of oxidative phosphorylation in heart mitochondria.
Kholodenko B, Zhilinskene V, Borutaĭte V, Ivanovene L, Toleĭkis A. The role of adenine nucleotide translocator in the regulation of oxidative phosphorylation in heart mitochondria. Биохимия 1988, 53: 1009-12. PMID: 2846076.Peer-Reviewed Original ResearchConceptsAdenine nucleotide translocaseOxidative phosphorylationNucleotide translocaseADP/ATP translocaseHeart mitochondriaATP translocaseTitration of respirationTranslocaseRegulatory rolePhosphorylationRabbit heart mitochondriaMitochondriaRespiration rateRole of adenineRegulationRespirationKey roleState 3TranslocatorRoleCarboxyatractylosideControl coefficientsADP
1987
The role of adenine nucleotide translocators in regulation of oxidative phosphorylation in heart mitochondria
Kholodenko B, Z̆ilinskie·e V, Borutait·e V, Ivanovien·e L, Toleikis A, Pras̆kevic̆ius A. The role of adenine nucleotide translocators in regulation of oxidative phosphorylation in heart mitochondria. FEBS Letters 1987, 223: 247-250. PMID: 2822484, DOI: 10.1016/0014-5793(87)80298-3.Peer-Reviewed Original ResearchConceptsAdenine nucleotide translocatorOxidative phosphorylationNucleotide translocatorHeart mitochondriaRespiration rateTitration of respirationPhosphorylationTranslocatorRabbit heart mitochondriaMitochondriaRegulative roleState 4RegulationKey roleState 3RoleCarboxyatractylosideRespirationControl coefficientsADP