2015
Signalling mechanisms regulating phenotypic changes in breast cancer cells
Volinsky N, McCarthy CJ, von Kriegsheim A, Saban N, Okada-Hatakeyama M, Kolch W, Kholodenko BN. Signalling mechanisms regulating phenotypic changes in breast cancer cells. Bioscience Reports 2015, 35: e00178. PMID: 25643809, PMCID: PMC4370098, DOI: 10.1042/bsr20140172.Peer-Reviewed Original ResearchConceptsCell fate decisionsATP-citrate lyaseFate decisionsPhenotypic changesBreast cancer cellsEpidermal growth factorCell fate decision processesCancer cellsLipid accumulationIrreversible phenotypic changesPhosphoinositide-3 kinaseSimilar cellular responsesPI3K pathwayGrowth factorRapamycin complexKinase pathwayNegative regulatorMolecular mechanismsCellular responsesMetabolic pathwaysMammalian targetK pathwayCitrate lyaseLipogenic pathwayCell proliferation
2008
Multi‐scale modeling of neuronal adaptation mediated by angiotensin II in the central regulation of blood pressure
Vadigepalli R, Nikolaev E, Miller G, Ogunnaike B, Gonye G, Kholodenko B, Schwaber J. Multi‐scale modeling of neuronal adaptation mediated by angiotensin II in the central regulation of blood pressure. The FASEB Journal 2008, 22: 756.2-756.2. DOI: 10.1096/fasebj.22.1_supplement.756.2.Peer-Reviewed Original ResearchRelease of norepinephrineAngiotensin II receptorsSynthesis of norepinephrineType 1 activationAP-1PI3K pathwayCardiorespiratory neuronsBlood pressureAngiotensin IIC-Jun activationCardiovascular regulationCNS neuronsLong-term effectsCentral regulationTyrosine hydroxylaseTranscription factor AP-1Rate-limiting enzymeII receptorsKey neurotransmitterNeuronal adaptationFactor AP-1NorepinephrineK pathwayC-fos