Multi‐scale modeling of neuronal adaptation mediated by angiotensin II in the central regulation of blood pressure
Vadigepalli R, Nikolaev E, Miller G, Ogunnaike B, Gonye G, Kholodenko B, Schwaber J. Multi‐scale modeling of neuronal adaptation mediated by angiotensin II in the central regulation of blood pressure. The FASEB Journal 2008, 22: 756.2-756.2. DOI: 10.1096/fasebj.22.1_supplement.756.2.Peer-Reviewed Original ResearchRelease of norepinephrineAngiotensin II receptorsSynthesis of norepinephrineType 1 activationAP-1PI3K pathwayCardiorespiratory neuronsBlood pressureAngiotensin IIC-Jun activationCardiovascular regulationCNS neuronsLong-term effectsCentral regulationTyrosine hydroxylaseTranscription factor AP-1Rate-limiting enzymeII receptorsKey neurotransmitterNeuronal adaptationFactor AP-1NorepinephrineK pathwayC-fos