Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development
Shapiro LP, Parsons RG, Koleske AJ, Gourley SL. Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development. Journal Of Neuroscience Research 2016, 95: 1123-1143. PMID: 27735056, PMCID: PMC5352542, DOI: 10.1002/jnr.23960.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge FactorsAnalysis of VarianceAnimalsBrain-Derived Neurotrophic FactorCytoskeletonDendritic SpinesFemaleGene Expression Regulation, DevelopmentalHumansIntegrin beta1MaleMembrane GlycoproteinsMiceMice, TransgenicNeural PathwaysNeuronsPrefrontal CortexReceptor, trkBSignal TransductionSynapsesSynaptophysinConceptsPrefrontal cortexDendritic spinesTropomyosin-related kinase receptor BDifferent adolescent agesKinase receptor BPrevalence of depressionMental health disordersDeep-layer excitatory neuronsRho kinase 2TrkB levelsVentral hippocampusOrbital prefrontal cortexAge-related differencesPsychiatric illnessReceptor BExcitatory neuronsPostnatal brainHealth disordersAnatomical connectionsNeuronal structuresWestern blottingAdolescent ageEarly adulthoodDramatic structural reorganizationPFC subregionsDendrite Maintenance
Katrancha S, Koleske A. Dendrite Maintenance. 2016, 317-355. DOI: 10.1007/978-4-431-56050-0_14.Peer-Reviewed Original ResearchDendritic spinesArbor stabilityDendrite arborsCytoplasmic nonreceptor tyrosine kinaseDendritic spine formationDendritic spine stabilityProper brain functionPsychiatric illnessSpine stabilityDifferent pathological statesSynaptic connectionsSpine formationBrain functionNormal agingNeurodegenerative diseasesMajor contributing factorSpinePathological statesReceptorsArborsEph receptorsContributing factorTyrosine kinaseCell surface adhesion receptorsMolecular mechanisms