Magnetic resonance imaging of regional gray matter volume in persons who died by suicide
Deininger-Czermak E, Spencer L, Zoelch N, Sankar A, Gascho D, Guggenberger R, Mathieu S, Thali M, Blumberg H. Magnetic resonance imaging of regional gray matter volume in persons who died by suicide. Molecular Psychiatry 2024, 1-5. PMID: 39237718, DOI: 10.1038/s41380-024-02730-2.Peer-Reviewed Original ResearchGray matter volumeMatter volumeBrain regionsIn vivo neuroimaging researchRegional gray matter volumeGray matter volume measurementsBrain voxel-based analysisStudy of suicideEmotion regulationNeuroimaging researchSuicide attemptsSelf-perceptionSuicideCompare personsMagnetic resonance imagingSuicide deathsPersonsBrainAmygdalaInsulaStriatumNeuroimagingMotivationIndividualsHypothesisNeocortical serotonin 2A receptor binding, neuroticism and risk of developing depression in healthy individuals
Sankar A, Ziersen S, Ozenne B, Dam V, Beaman E, Kessing L, Fisher P, Budtz-Jørgensen E, Knudsen G, Miskowiak K, Frokjaer V. Neocortical serotonin 2A receptor binding, neuroticism and risk of developing depression in healthy individuals. Nature Mental Health 2024, 1-8. DOI: 10.1038/s44220-024-00299-x.Peer-Reviewed Original ResearchRisk of depressionFacets of neuroticismPersonality trait neuroticismPathophysiology of depressionSerotonin 2A receptorMolecular brain imagingHigh neuroticismTrait neuroticismDepressive episodeNeuroticismDepression diagnosisHealthy individualsDepressionReceptor bindingBrain imagingDanish registersCause-specific Cox regression analysesEvaluation of clinical strategiesIndividualsCox regression analysisPsychotherapyClinical strategiesPsychedelicsSerotoninRegression analysis