2013
Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips
Gudimchuk N, Vitre B, Kim Y, Kiyatkin A, Cleveland DW, Ataullakhanov FI, Grishchuk EL. Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips. Nature Cell Biology 2013, 15: 1079-1088. PMID: 23955301, PMCID: PMC3919686, DOI: 10.1038/ncb2831.Peer-Reviewed Original ResearchConceptsDynamic microtubule endsMicrotubule endsMicrotubule tipsKinetochore kinesin CENPCENP-E motorDynamic microtubule tipsSingle-molecule approachVertebrate mitosisSpindle microtubulesTail domainCENPStable associationKinetochoresPlus endsChromosomesMolecular frameworkCentromeresMitosisMicrotubulesTransportersMotor mechanismsStability of attachmentVitroActive roleComputational modelling
2004
Signal processing at the Ras circuit: what shapes Ras activation patterns?
Markevich NI, Moehren G, Demin OV, Kiyatkin A, Hoek JB, Kholodenko BN. Signal processing at the Ras circuit: what shapes Ras activation patterns? IET Systems Biology 2004, 1: 104-13. PMID: 17052120, DOI: 10.1049/sb:20045003.Peer-Reviewed Original ResearchConceptsP190 RhoGAPEpidermal growth factorActive GTP-bound stateGDP/GTP exchange factorGTP-bound stateSmall GTPase RasCellular signal transductionGTP exchange factorSystems biology approachSoluble tyrosine kinaseReceptor-mediated recruitmentSOS activationRasGAP activityRas proteinsCell fateExchange factorGTPase RasBiology approachRas mutantsSignal transductionInhibitory phosphorylationGTPase activityPlasma membraneRasGAPRegulatory mechanisms