Dynamic cross‐talk between PI3‐kinase/Akt and Ras/ERK pathways in EGF receptor signaling that can affect drug sensitivity in tumor cells
Aksamitiene E, Kiyatkin A, Hoek J. Dynamic cross‐talk between PI3‐kinase/Akt and Ras/ERK pathways in EGF receptor signaling that can affect drug sensitivity in tumor cells. The FASEB Journal 2010, 24: 715.2-715.2. DOI: 10.1096/fasebj.24.1_supplement.715.2.Peer-Reviewed Original ResearchPI3KRas/ERK pathwayPI3-kinase/AktPI3K activityEGF dose-dependent mannerNegative feedback loopAdaptor proteinMitogenic signalingU0126 inhibitorIndependent parallel pathwaysERK activityEGF receptorERK pathwayCell survivalK activityReciprocal crosstalkERK responseRecruitment mechanismsPhosphorylated ERKImmunoblot analysisEGF dosesERKAkt expressionSubcellular fractionsCancer cells