2022
Predictors of survival and time to progression following operative management of intramedullary spinal cord astrocytomas
Hersh AM, Antar A, Pennington Z, Aygun N, Patel J, Goldsborough E, Porras JL, Elsamadicy AA, Lubelski D, Wolinsky JP, Jallo GI, Gokaslan ZL, Lo SL, Sciubba DM. Predictors of survival and time to progression following operative management of intramedullary spinal cord astrocytomas. Journal Of Neuro-Oncology 2022, 158: 117-127. PMID: 35538385, DOI: 10.1007/s11060-022-04017-4.Peer-Reviewed Original ResearchConceptsProgression-free survivalPredictors of survivalHigh tumor gradeResection extentTumor gradePoor survivalIntramedullary spinal cord astrocytomasPost-operative neurologic deficitsSingle comprehensive cancer centerTumor progression/recurrencePreoperative back painPre-operative presentationSpinal cord astrocytomasKaplan-Meier curvesProgression/recurrenceStandard of careComprehensive cancer centerLong-term survivalPurposeSurgical resectionBowel dysfunctionChemotherapy regimensNeurologic deficitsIntramedullary astrocytomasPatient demographicsComplete resectionA novel online calculator to predict nonroutine discharge, length of stay, readmission, and reoperation in patients undergoing surgery for intramedullary spinal cord tumors
Hersh AM, Patel J, Pennington Z, Antar A, Goldsborough E, Porras JL, Feghali J, Elsamadicy AA, Lubelski D, Wolinsky JP, Jallo GI, Gokaslan ZL, Lo SL, Sciubba DM. A novel online calculator to predict nonroutine discharge, length of stay, readmission, and reoperation in patients undergoing surgery for intramedullary spinal cord tumors. The Spine Journal 2022, 22: 1345-1355. PMID: 35342014, DOI: 10.1016/j.spinee.2022.03.005.Peer-Reviewed Original ResearchConceptsIntramedullary spinal cord tumorsModified McCormick ScaleSpinal cord tumorsNonroutine dischargeDay readmissionIndependent predictorsWeb-based calculatorBowel dysfunctionNonhome dischargePatient demographicsCord tumorsIncision lengthHigher preoperative white blood cell countResection of ISCTsPreoperative white blood cell countStepwise multivariable logistic regression modelSingle comprehensive cancer centerWhite blood cell countMultivariable logistic regression modelRetrospective cohort study PATIENT SAMPLEBaseline neurological statusDays unplanned readmissionLonger incision lengthNovel online calculatorPreoperative neurological symptoms
2021
Impact of race on nonroutine discharge, length of stay, and postoperative complications after surgery for spinal metastases.
Hung B, Pennington Z, Hersh AM, Schilling A, Ehresman J, Patel J, Antar A, Porras JL, Elsamadicy AA, Sciubba DM. Impact of race on nonroutine discharge, length of stay, and postoperative complications after surgery for spinal metastases. Journal Of Neurosurgery Spine 2021, 36: 678-685. PMID: 34740176, DOI: 10.3171/2021.7.spine21287.Peer-Reviewed Original ResearchConceptsLow preoperative KPS scoreNonroutine dischargePreoperative KPS scoreSpinal metastasesInsurance statusPostoperative complicationsKPS scoreIndependent predictorsFunctional statusPreoperative Karnofsky Performance Scale scoreHigher Charlson comorbidity indexSingle comprehensive cancer centerKarnofsky Performance Scale scoreStepwise multivariable logistic regressionFrankel grade ANonhome discharge destinationCharlson Comorbidity IndexPreoperative clinical characteristicsPrimary tumor typeBaseline functional statusMultivariable logistic regressionMarital statusLength of stayPerformance Scale scoreComprehensive cancer centerUtility of expanded anterior column resection versus decompression-alone for local control in the management of carcinomatous vertebral column metastases undergoing adjuvant stereotactic radiotherapy
Pennington Z, Pairojboriboon S, Chen X, Sacino A, Elsamadicy AA, de la Garza Ramos R, Patel J, Elder BD, Kleinberg LR, Sciubba DM, Redmond KJ, Lo SL. Utility of expanded anterior column resection versus decompression-alone for local control in the management of carcinomatous vertebral column metastases undergoing adjuvant stereotactic radiotherapy. The Spine Journal 2021, 22: 835-846. PMID: 34718175, DOI: 10.1016/j.spinee.2021.10.016.Peer-Reviewed Original ResearchConceptsStereotactic body radiotherapyLong-term local controlLocal recurrenceLocal controlAnterior columnTumor pathologyCommon primary tumor typesSingle comprehensive cancer centerAdjuvant stereotactic radiotherapySpinal column metastasesVertebral Column MetastasesRetrospective cohort studyLocal control ratePrimary tumor typeLocal tumor recurrenceComprehensive cancer centerKaplan-Meier functionInvasive surgical techniquesEpidural removalAdjuvant radiotherapySurgical debulkingCohort studyDisease resectionSpinal metastasesTumor involvementA Web-Based Calculator for Predicting the Occurrence of Wound Complications, Wound Infection, and Unplanned Reoperation for Wound Complications in Patients Undergoing Surgery for Spinal Metastases
Hersh AM, Feghali J, Hung B, Pennington Z, Schilling A, Antar A, Patel J, Ehresman J, Cottrill E, Lubelski D, Elsamadicy AA, Goodwin CR, Lo SL, Sciubba DM. A Web-Based Calculator for Predicting the Occurrence of Wound Complications, Wound Infection, and Unplanned Reoperation for Wound Complications in Patients Undergoing Surgery for Spinal Metastases. World Neurosurgery 2021, 155: e218-e228. PMID: 34403800, DOI: 10.1016/j.wneu.2021.08.041.Peer-Reviewed Original ResearchConceptsLow platelet countWound complicationsPlatelet countUnplanned reoperationWound infectionRevision surgeryWeb-based calculatorIncision lengthHigher CCIHigher Charlson comorbidity indexSingle comprehensive cancer centerKarnofsky Performance Scale scoreLonger incision lengthCharlson Comorbidity IndexWound-related complicationsIndependent predictive factorsSurgical site infectionMultivariable logistic regressionPerformance Scale scoreComprehensive cancer centerOptimism-corrected areaPoor health statusComorbidity indexIndex surgeryMetastasis surgery