2022
Assessment of Spinal Metastases Surgery Risk Stratification Tools in Breast Cancer by Molecular Subtype
Duvall J, Massaad E, Siraj L, Kiapour A, Connolly I, Hadzipasic M, Elsamadicy A, Williamson T, Shankar G, Schoenfeld A, Fourman M, Shin J. Assessment of Spinal Metastases Surgery Risk Stratification Tools in Breast Cancer by Molecular Subtype. Neurosurgery 2022, 92: 83-91. PMID: 36305664, PMCID: PMC10158884, DOI: 10.1227/neu.0000000000002180.Peer-Reviewed Original ResearchConceptsHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Triple-negative breast cancerGrowth factor receptor 2Factor receptor 2Breast cancerHazard ratioSpine metastasesMolecular subtypesReceptor 2Retrospective multi-institutional studyHormone receptorsBreast cancer molecular subtypesPostoperative systemic therapySystemic treatment plansPoor physical activityRisk stratification toolSpinal metastasis surgeryCancer molecular subtypesMulti-institutional studyMassachusetts General HospitalMolecular featuresPostoperative chemotherapyBrain metastasesEndocrine therapy
2020
Laser interstitial thermal therapy in neuro-oncology applications
Hong CS, Kundishora AJ, Elsamadicy AA, Chiang VL. Laser interstitial thermal therapy in neuro-oncology applications. Surgical Neurology International 2020, 11: 231. PMID: 32874734, PMCID: PMC7451173, DOI: 10.25259/sni_496_2019.Peer-Reviewed Original ResearchLaser interstitial thermal therapyRadiation necrosisInterstitial thermal therapyBrain tumorsNeurosurgical oncologyMultiple intracranial pathologiesRole of LITTStandard craniotomy approachesOptimal patient selectionMetastatic brain tumorsOpen surgical resectionInvasive surgical treatmentLesion-specific characteristicsSymptomatic peritumoral edemaNeuro-oncology applicationsMedical comorbiditiesBrain metastasesSurgical resectionSurgical treatmentPatient selectionRecurrent tumorsTumor characteristicsOpen surgeryCare treatmentCraniotomy approachLaser interstitial thermal therapy for treatment of cerebral radiation necrosis
Hong CS, Beckta JM, Kundishora AJ, Elsamadicy AA, Chiang VL. Laser interstitial thermal therapy for treatment of cerebral radiation necrosis. International Journal Of Hyperthermia 2020, 37: 68-76. PMID: 32672119, DOI: 10.1080/02656736.2020.1760362.Peer-Reviewed Original ResearchConceptsLaser interstitial thermal therapyInterstitial thermal therapyRadiation necrosisRecurrent tumorsCerebral radiation necrosisPeri-operative morbidityBrain metastasis patientsFirst-line therapyAlternative surgical optionReal-time imaging guidanceOpen surgical resectionPersistence of symptomsTreatment of patientsDeep-seated lesionsTissue inflammatory responseAmenable lesionsChronic steroidsBrain metastasesMetastasis patientsSurgical resectionSymptomatic patientsMedical managementSurgical optionsSurgical historyIntracranial pathologyLaser interstitial thermal therapy (LITT) vs. bevacizumab for radiation necrosis in previously irradiated brain metastases
Sujijantarat N, Hong CS, Owusu KA, Elsamadicy AA, Antonios JP, Koo AB, Baehring JM, Chiang VL. Laser interstitial thermal therapy (LITT) vs. bevacizumab for radiation necrosis in previously irradiated brain metastases. Journal Of Neuro-Oncology 2020, 148: 641-649. PMID: 32602021, DOI: 10.1007/s11060-020-03570-0.Peer-Reviewed Original ResearchConceptsLaser interstitial thermal therapyLonger overall survivalRadiation necrosisInterstitial thermal therapyBrain metastasesOverall survivalMedian volume decreaseMedian volume increaseBrain metastasis patientsPre-treatment patient characteristicsRetrospective chart reviewResultsTwenty-five patientsPre-treatment factorsBevacizumab patientsChart reviewMetastasis patientsLocal recurrencePatient characteristicsTreatment optionsTreatment responseBevacizumabPatientsLesional volumeThermal therapyStatistical significance