2011
Control of antiviral immunity by pattern recognition and the microbiome
Pang IK, Iwasaki A. Control of antiviral immunity by pattern recognition and the microbiome. Immunological Reviews 2011, 245: 209-226. PMID: 22168422, PMCID: PMC3659816, DOI: 10.1111/j.1600-065x.2011.01073.x.Peer-Reviewed Original ResearchConceptsAdaptive immunityInnate pattern recognition receptorsChronic viral infectionsAdaptive immune responsesExtra-intestinal infectionsHost immune systemPattern recognition receptorsTransduce signalsImmune activationAutoimmune diseasesProbiotic therapyMammalian hostsImmune responseAntiviral immunityViral infectionMucosal surfacesViral recognitionImmune systemInvasive microbesProper developmentMicrobial sensingResident microbiotaInnate defenseSuch diseasesHost susceptibility
2009
Autophagy and Innate Recognition Systems
Tal MC, Iwasaki A. Autophagy and Innate Recognition Systems. Current Topics In Microbiology And Immunology 2009, 335: 107-121. PMID: 19802562, DOI: 10.1007/978-3-642-00302-8_5.Peer-Reviewed Original ResearchConceptsAutophagic machineryInnate immune systemDouble-membrane structureViral replication complexProcess of autophagyImportant physiological processesInduction of autophagyInnate recognition systemsCellular homeostasisReplication complexPattern recognition receptorsAutophagy pathwayLysosomal degradationPhysiological processesCytosolic constituentsEfficient phagocytosisInnate pattern recognition receptorsRNA virusesAutophagyCytosolic sensorsKey moleculesExtracellular pathogensRecognition receptorsImmune systemViral sensors