2013
Role of fibrinogen in massive injury.
Maung AA, Kaplan LJ. Role of fibrinogen in massive injury. Minerva Anestesiologica 2013, 80: 89-95. PMID: 23857437.Peer-Reviewed Original ResearchConceptsRole of fibrinogenTrauma associated coagulopathyAcute traumatic coagulopathyEffect of acidosisLow fibrinogen concentrationAssociated coagulopathyControl hemorrhageTraumatic coagulopathyMassive hemorrhageFactor consumptionRotational thromboelastometryHyperfibrinolysisTherapeutic interventionsCoagulopathyInjuryFibrinogen concentrationMassive injuryHemorrhageComplex cascadeHypofibrinogenemia
2012
Mechanical Ventilation After Injury
Maung AA, Kaplan LJ. Mechanical Ventilation After Injury. Journal Of Intensive Care Medicine 2012, 29: 128-137. PMID: 22956744, DOI: 10.1177/0885066612457339.Peer-Reviewed Original ResearchConceptsMechanical ventilationPrimary respiratory failureTraumatic brain injuryMultiple organ systemsImpact of injuryConcomitant tissue injuryRespiratory failureCritical illnessVentilator strategiesBronchopleural fistulaVentilator managementBrain injuryPhysiologic changesTissue injuryBlast injuryInjuryThermal injuryOrgan systemsPatientsMajor causeVentilationSpecial considerationFistulaIllnessCompared to conventional ventilation, airway pressure release ventilation may increase ventilator days in trauma patients
Maung AA, Schuster KM, Kaplan LJ, Ditillo MF, Piper GL, Maerz LL, Lui FY, Johnson DC, Davis KA. Compared to conventional ventilation, airway pressure release ventilation may increase ventilator days in trauma patients. Journal Of Trauma And Acute Care Surgery 2012, 73: 507-510. PMID: 23019679, DOI: 10.1097/ta.0b013e31825ff653.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedContinuous Positive Airway PressureCritical CareDatabases, FactualFemaleFollow-Up StudiesHumansInjury Severity ScoreIntra-Abdominal HypertensionLength of StayLinear ModelsMaleMiddle AgedMultivariate AnalysisPulmonary Gas ExchangeRespiration, ArtificialRetrospective StudiesRisk AssessmentSurvival RateTime FactorsTrauma CentersTreatment OutcomeVentilator WeaningWounds and InjuriesConceptsAirway pressure release ventilationTotal ventilator daysVentilator daysHospital complicationsMechanical ventilationAIS scoreChest Abbreviated Injury Scale scoreAbbreviated Injury Scale scoreSpontaneous breathing trialAbdominal compartment syndromeAcute lung injuryAcute renal failureInjury Scale scoreStudy entry criteriaInjury Severity ScorePotential confounding factorsAPRV groupAPRV modeBreathing trialRescue therapyCompartment syndromeLung injuryRenal failureIndependent predictorsRetrospective review
2011
Routine or Protocol Evaluation of Trauma Patients With Suspected Syncope is Unnecessary
Maung AA, Kaplan LJ, Schuster KM, Johnson DC, Davis KA. Routine or Protocol Evaluation of Trauma Patients With Suspected Syncope is Unnecessary. Journal Of Trauma And Acute Care Surgery 2011, 70: 428-432. PMID: 21307745, DOI: 10.1097/ta.0b013e31820958be.Peer-Reviewed Original ResearchConceptsDiagnostic workupCardiac enzymesSyncope workupAbnormal resultsStudy entry criteriaInjury Severity ScoreCause of injuryMotor vehicle collisionsSignificant abnormal resultsStandardized workupRetrospective reviewTrauma patientsCarotid duplexPhysical examinationSeverity scoreTomography angiographyEntry criteriaFemale genderFurther interventionClinical informationLevel ISyncopePatientsSubsequent interventionsWorkup
2006
Platelet depletion in mice increases mortality after thermal injury
Fujimi S, MacConmara MP, Maung AA, Zang Y, Mannick JA, Lederer JA, Lapchak PH. Platelet depletion in mice increases mortality after thermal injury. Blood 2006, 107: 4399-4406. PMID: 16467203, PMCID: PMC1895793, DOI: 10.1182/blood-2005-09-3776.Peer-Reviewed Original ResearchConceptsControl miceFull-thickness total body surface areaHost responseThermal injuryTotal body surface areaExperimental control miceSystemic inflammatory responsePlatelet-depleted miceRole of plateletsBody surface areaCause of deathCritical protective rolePeripheral blood monocytesImportance of plateletsSham injuryIL-6MCP-1Plasma levelsPlatelet depletionInflammatory responseImmune responseAdaptive immunityBlood monocytesMouse modelProtective roleIncreased CD4+ CD25+ T Regulatory Cell Activity in Trauma Patients Depresses Protective Th1 Immunity
MacConmara MP, Maung AA, Fujimi S, McKenna AM, Delisle A, Lapchak PH, Rogers S, Lederer JA, Mannick JA. Increased CD4+ CD25+ T Regulatory Cell Activity in Trauma Patients Depresses Protective Th1 Immunity. Annals Of Surgery 2006, 124: 179-188. PMID: 16998360, PMCID: PMC1856576, DOI: 10.1097/01.sla.0000239031.06906.1f.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedCD4-Positive T-LymphocytesFemaleHumansMaleMiddle AgedReceptors, Interleukin-2Th1 CellsT-LymphocytesWounds and InjuriesConceptsCD4 T cellsT cell proliferationT cellsDay 1IL-10IFNgamma productionDay 7Inhibitory cytokine IL-10Patient CD4 T cellsCD4 T cell proliferationCD3/CD28 antibodiesTh1-type immunityCytokine IL-10Regulatory cell activityTh1 cytokine productionCytometric bead arrayT Regulatory Cell ActivityTh2-type cytokinesProtective Th1 immunityCell proliferationT cell activationActivation of cellsIncreased CD4Treg activityTreg suppression