2011
High levels of histidine decarboxylase in the striatum of mice and rats
Krusong K, Ercan-Sencicek AG, Xu M, Ohtsu H, Anderson GM, State MW, Pittenger C. High levels of histidine decarboxylase in the striatum of mice and rats. Neuroscience Letters 2011, 495: 110-114. PMID: 21440039, PMCID: PMC3081964, DOI: 10.1016/j.neulet.2011.03.050.Peer-Reviewed Original ResearchConceptsPosterior hypothalamusBasal gangliaHistamine receptorsHistidine decarboxylaseHDC knockout miceStriatum of miceCentral nervous systemHDC proteinTuberomamillary nucleusFunctional innervationHistamine metabolismAxonal projectionsMouse striatumHigh levelsKnockout miceForebrain structuresHistamine levelsNervous systemStriatumNeurotransmitter histamineWestern blotHypothalamusRatsMiceSimilar high levels
2008
Molecular Cytogenetic Analysis and Resequencing of Contactin Associated Protein-Like 2 in Autism Spectrum Disorders
Bakkaloglu B, O'Roak BJ, Louvi A, Gupta AR, Abelson JF, Morgan TM, Chawarska K, Klin A, Ercan-Sencicek AG, Stillman AA, Tanriover G, Abrahams BS, Duvall JA, Robbins EM, Geschwind DH, Biederer T, Gunel M, Lifton RP, State MW. Molecular Cytogenetic Analysis and Resequencing of Contactin Associated Protein-Like 2 in Autism Spectrum Disorders. American Journal Of Human Genetics 2008, 82: 165-173. PMID: 18179895, PMCID: PMC2253974, DOI: 10.1016/j.ajhg.2007.09.017.Peer-Reviewed Original ResearchConceptsAutism susceptibility candidate 2Contactin 4Plasma membrane fractionSynaptic plasma membrane fractionMolecular cytogenetic analysisComplex genetic etiologyRare variantsBioinformatics approachConserved positionNonsynonymous changesMembrane fractionRare homozygous mutationControl chromosomesBiochemical analysisNeurodevelopmental syndromeGenetic etiologyPathophysiology of ASDCandidate 2Recent findingsHomozygous mutationUnrelated familiesCytogenetic analysisMutationsVariantsResequencing