2023
Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement
Hohenschurz-Schmidt D, Cherkin D, Rice A, Dworkin R, Turk D, McDermott M, Bair M, DeBar L, Edwards R, Farrar J, Kerns R, Markman J, Rowbotham M, Sherman K, Wasan A, Cowan P, Desjardins P, Ferguson M, Freeman R, Gewandter J, Gilron I, Grol-Prokopczyk H, Hertz S, Iyengar S, Kamp C, Karp B, Kleykamp B, Loeser J, Mackey S, Malamut R, McNicol E, Patel K, Sandbrink F, Schmader K, Simon L, Steiner D, Veasley C, Vollert J. Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement. Pain 2023, 164: 1457-1472. PMID: 36943273, PMCID: PMC10281023, DOI: 10.1097/j.pain.0000000000002888.Peer-Reviewed Original ResearchConceptsPragmatic trialPain treatmentClinical careSystematic reviewAddiction Clinical Trial TranslationsNetworks (ACTTION) public-private partnershipTraditional efficacy trialsRoutine clinical careDaily clinical carePragmatic clinical trialsEvidence-based treatmentsRelated health policiesInternal validityPain assessmentClinical managementClinical trialsEfficacy trialsConsensus meetingTrial designConsensus discussionTrial objectivesSuch trialsHealth policyTrialsExpert presentations
2017
Classifying clinical notes with pain assessment using machine learning
Fodeh SJ, Finch D, Bouayad L, Luther SL, Ling H, Kerns RD, Brandt C. Classifying clinical notes with pain assessment using machine learning. Medical & Biological Engineering & Computing 2017, 56: 1285-1292. PMID: 29280092, PMCID: PMC6014866, DOI: 10.1007/s11517-017-1772-1.Peer-Reviewed Original ResearchConceptsPain care qualityPain assessmentClinical notesChronic painMusculoskeletal diagnosesSignificant public health problemCharacteristics of patientsIntensity of painType of painPublic health problemPain sitesPain complaintsPatient reportsPainPatientsHealth problemsCare qualityFiscal year 2011Health recordsMillions of peopleComplete dataClinical applicationDiagnosisDemographic variablesWide spectrumTaking ACTION to reduce pain: ACTION study rationale, design and protocol of a randomized trial of a proactive telephone-based coaching intervention for chronic musculoskeletal pain among African Americans
Bhimani RH, Cross LJ, Taylor BC, Meis LA, Fu SS, Allen KD, Krein SL, Do T, Kerns RD, Burgess DJ. Taking ACTION to reduce pain: ACTION study rationale, design and protocol of a randomized trial of a proactive telephone-based coaching intervention for chronic musculoskeletal pain among African Americans. BMC Musculoskeletal Disorders 2017, 18: 15. PMID: 28086853, PMCID: PMC5237146, DOI: 10.1186/s12891-016-1363-6.Peer-Reviewed Original ResearchConceptsChronic musculoskeletal painMusculoskeletal painTreatment outcomesHealth care service utilizationMorris Disability QuestionnairePain outcome measuresPain treatment outcomesTelephone counseling sessionsAfrican American patientsAfrican AmericansPrimary aimUsual careDisability QuestionnaireOpioid analgesicsPain outcomesPain treatmentPrimary outcomeChronic painPain assessmentTreat methodologyAmerican patientsClinical trialsPhysical functioningService utilizationOutcome measuresClassifying Clinical Notes with Pain Assessment.
Fodeh SJ, Finch D, Bouayad L, Luther S, Kerns RD, Brandt C. Classifying Clinical Notes with Pain Assessment. 2017, 245: 1261. PMID: 29295346.Peer-Reviewed Original Research
2016
Improving pain care through implementation of the Stepped Care Model at a multisite community health center
Anderson DR, Zlateva I, Coman EN, Khatri K, Tian T, Kerns RD. Improving pain care through implementation of the Stepped Care Model at a multisite community health center. Journal Of Pain Research 2016, Volume 9: 1021-1029. PMID: 27881926, PMCID: PMC5115680, DOI: 10.2147/jpr.s117885.Peer-Reviewed Original ResearchPrimary care providersPain knowledge scoresCommunity health centersStepped care modelPain careHealth centersCare modelMultisite community health centerFederally Qualified Health CentersOpioid treatment agreementsQualified health centersUrine drug screensDocumentation of painHealth Services frameworkSafety-net practicesElectronic health recordsOpioid prescribingChart reviewPain managementPain outcomesPain treatmentChronic painPain assessmentTreatment agreementsPrimary carePain intensity rating training
Smith SM, Amtmann D, Askew RL, Gewandter JS, Hunsinger M, Jensen MP, McDermott MP, Patel KV, Williams M, Bacci ED, Burke LB, Chambers CT, Cooper SA, Cowan P, Desjardins P, Etropolski M, Farrar JT, Gilron I, Huang IZ, Katz M, Kerns RD, Kopecky EA, Rappaport BA, Resnick M, Strand V, Vanhove GF, Veasley C, Versavel M, Wasan AD, Turk DC, Dworkin RH. Pain intensity rating training. Pain 2016, 157: 1056-1064. PMID: 27058680, DOI: 10.1097/j.pain.0000000000000502.Peer-Reviewed Original ResearchConceptsPain intensity ratingsAverage pain intensity ratingsPain assessmentPainful diabetic peripheral neuropathyAddiction Clinical Trial TranslationsNetworks (ACTTION) public-private partnershipDiabetic peripheral neuropathyIntensity ratingsLow back painPatient-reported outcomesClinical trial participantsPeripheral neuropathyPain fluctuationsTreatment trialsTrial participantsSignificant differencesStandardized guidanceDiscriminant validityParticipantsGroupMost measuresNeuropathyAnalgesicsPainAssessmentResearch design considerations for single-dose analgesic clinical trials in acute pain
Cooper SA, Desjardins PJ, Turk DC, Dworkin RH, Katz NP, Kehlet H, Ballantyne JC, Burke LB, Carragee E, Cowan P, Croll S, Dionne RA, Farrar JT, Gilron I, Gordon DB, Iyengar S, Jay GW, Kalso EA, Kerns RD, McDermott MP, Raja SN, Rappaport BA, Rauschkolb C, Royal MA, Segerdahl M, Stauffer JW, Todd KH, Vanhove GF, Wallace MS, West C, White RE, Wu C. Research design considerations for single-dose analgesic clinical trials in acute pain. Pain 2016, 157: 288-301. PMID: 26683233, DOI: 10.1097/j.pain.0000000000000375.Peer-Reviewed Original ResearchConceptsClinical trialsEarly phase clinical trialsAcute pain studiesAcute pain trialsPain clinical trialsAnalgesic clinical trialsPhase clinical trialsShort-duration trialsPostoperative painAcute painPain trialsPain assessmentStudy design factorsPain studiesDental impactionStudy designTrialsPainAssessment measuresResearch design considerationsPlaceboSurgeryBunionectomyDifferent settings
2014
Using Multiple Daily Pain Ratings to Improve Reliability and Assay Sensitivity: How Many Is Enough?
Heapy A, Dziura J, Buta E, Goulet J, Kulas JF, Kerns RD. Using Multiple Daily Pain Ratings to Improve Reliability and Assay Sensitivity: How Many Is Enough? Journal Of Pain 2014, 15: 1360-1365. PMID: 25283469, DOI: 10.1016/j.jpain.2014.09.012.Peer-Reviewed Original ResearchConceptsPain intensity ratingsPain treatment trialsPain ratingsTreatment trialsIntensity ratingsDaily pain ratingsMedical Center patientsIMMPACT recommendationsBaseline measurement periodCenter patientsPain assessmentBland-Altman analysisClinical trialsSecondary data analysisDaily callsDaily ratingsTrialsMeaningful differencesAssay sensitivityMeasure reliabilityAdequate reliabilitySpecific recommendationsPatientsSmall subsetBaseline
2012
Considerations for improving assay sensitivity in chronic pain clinical trials: IMMPACT recommendations
Dworkin RH, Turk DC, Peirce-Sandner S, Burke LB, Farrar JT, Gilron I, Jensen MP, Katz NP, Raja SN, Rappaport BA, Rowbotham MC, Backonja M, Baron R, Bellamy N, Bhagwagar Z, Costello A, Cowan P, Fang WC, Hertz S, Jay GW, Junor R, Kerns RD, Kerwin R, Kopecky EA, Lissin D, Malamut R, Markman JD, McDermott MP, Munera C, Porter L, Rauschkolb C, Rice ASC, Sampaio C, Skljarevski V, Sommerville K, Stacey BR, Steigerwald I, Tobias J, Trentacosti AM, Wasan AD, Wells GA, Williams J, Witter J, Ziegler D. Considerations for improving assay sensitivity in chronic pain clinical trials: IMMPACT recommendations. Pain 2012, 153: 1148-1158. PMID: 22494920, DOI: 10.1016/j.pain.2012.03.003.Peer-Reviewed Original ResearchConceptsRecent randomized clinical trialsClinical trialsAnalgesic treatmentChronic pain clinical trialsPain clinical trialsAnalgesic drug developmentChronic pain treatmentChronic pain trialsRandomized clinical trialsAnalgesic clinical trialsNumber of patientsEvidence-based approachIMMPACT recommendationsPain treatmentPain trialsPharmacologic treatmentAnalgesic trialsPain assessmentAssay sensitivityEfficacious medicationsConsensus meetingNegative trialsImproved efficacyStudy designTrials
2009
Pain among Veterans of Operations Enduring Freedom and Iraqi Freedom: Do Women and Men Differ?
Haskell SG, Brandt CA, Krebs EE, Skanderson M, Kerns RD, Goulet JL. Pain among Veterans of Operations Enduring Freedom and Iraqi Freedom: Do Women and Men Differ? Pain Medicine 2009, 10: 1167-1173. PMID: 19818028, DOI: 10.1111/j.1526-4637.2009.00714.x.Peer-Reviewed Original ResearchConceptsModerate-severe painPersistent painFemale veteransPain assessmentOperation Enduring FreedomVeterans Administration servicesPrevalence of painTreatment of painVA outpatient clinicEnduring FreedomIraqi FreedomSex differencesOverall painObservational cohortPain disordersOutpatient clinicPain measuresVA carePainLast deploymentMen DifferVeteransSignificant differencesPrevalenceYears of observation
2007
Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations
Dworkin RH, Turk DC, Wyrwich KW, Beaton D, Cleeland CS, Farrar JT, Haythornthwaite JA, Jensen MP, Kerns RD, Ader DN, Brandenburg N, Burke LB, Cella D, Chandler J, Cowan P, Dimitrova R, Dionne R, Hertz S, Jadad AR, Katz NP, Kehlet H, Kramer LD, Manning DC, McCormick C, McDermott MP, McQuay HJ, Patel S, Porter L, Quessy S, Rappaport BA, Rauschkolb C, Revicki DA, Rothman M, Schmader KE, Stacey BR, Stauffer JW, von Stein T, White RE, Witter J, Zavisic S. Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations. Journal Of Pain 2007, 9: 105-121. PMID: 18055266, DOI: 10.1016/j.jpain.2007.09.005.Peer-Reviewed Original ResearchConceptsChronic pain clinical trialsPain clinical trialsChronic pain treatmentClinical trialsSpecific outcome measuresClinical importanceTreatment outcomesOutcome measuresPain treatmentBrief Pain Inventory-InterferenceClinical trial outcome measuresPatient Global ImpressionChronic pain outcomesNumerical rating scaleTrial outcome measuresMultidimensional Pain InventoryPatient self-help organizationsBeck Depression InventoryIMMPACT recommendationsPain intensityPain outcomesPain InventoryChronic painPain assessmentGlobal Impression
2003
Rapid Improvement in Pain Management: The Veterans Health Administration and the Institute for Healthcare Improvement Collaborative
Cleeland CS, Reyes-Gibby CC, Schall M, Nolan K, Paice J, Rosenberg JM, Tollett JH, Kerns RD. Rapid Improvement in Pain Management: The Veterans Health Administration and the Institute for Healthcare Improvement Collaborative. The Clinical Journal Of Pain 2003, 19: 298-305. PMID: 12966255, DOI: 10.1097/00002508-200309000-00003.Peer-Reviewed Original ResearchMeSH KeywordsCooperative BehaviorHospitals, VeteransHumansInterinstitutional RelationsOrganizational ObjectivesPainPain ManagementPatient Care ManagementPatient Education as TopicPractice Patterns, Physicians'Program DevelopmentQuality Assurance, Health CareTreatment OutcomeUnited StatesUnited States Department of Veterans AffairsConceptsPain care planPain managementSevere painPain assessmentCare plansLeast mild painVeterans Integrated Service NetworkPercentage of patientsPoor pain managementNumber of patientsPatient-reported dataVeterans Health AdministrationRapid improvementMild painVHA patientsMajor health care organizationsPain educationPatientsHealth AdministrationSystem-wide effortsPainHealth care organizationsProcess measuresHealth careIntegrated Service Networks
2000
HIV/AIDS-related Pain as a Chronic Pain Condition: Implications of a Biopsychosocial Model for Comprehensive Assessment and Effective Management
Marcus K, Kerns R, Rosenfeld B, Breitbart W. HIV/AIDS-related Pain as a Chronic Pain Condition: Implications of a Biopsychosocial Model for Comprehensive Assessment and Effective Management. Pain Medicine 2000, 1: 260-273. PMID: 15101893, DOI: 10.1046/j.1526-4637.2000.00033.x.Peer-Reviewed Original ResearchHIV/AIDSHIV/AIDS patientsChronic pain conditionsChronic pain assessmentBiopsychosocial modelNegative psychosocial impactPain conditionsPain treatmentChronic painPain assessmentAIDS patientsMultimodal treatmentHigh prevalencePainPsychosocial barriersPsychosocial impactSubstance abuseTreatment issuesPsychosocial contributionsTreatmentAppropriate assessmentPrevalenceAIDSCurrent literatureSpecific recommendations
1984
Conceptual Issues in the Assessment of Clinical Pain
Turk D, Kerns R. Conceptual Issues in the Assessment of Clinical Pain. The International Journal Of Psychiatry In Medicine 1984, 13: 57-68. PMID: 6350203, DOI: 10.2190/rqar-ut6w-g4a0-tyhy.Peer-Reviewed Original Research