2018
A Randomized Pilot Trial of a Novel Behavioral Intervention for Chronic Pain Tailored to Individuals with HIV
Merlin JS, Westfall AO, Long D, Davies S, Saag M, Demonte W, Young S, Kerns RD, Bair MJ, Kertesz S, Turan JM, Kilgore M, Clay OJ, Starrels J, Pekmezi D, Johnson MO. A Randomized Pilot Trial of a Novel Behavioral Intervention for Chronic Pain Tailored to Individuals with HIV. AIDS And Behavior 2018, 22: 2733-2742. PMID: 29340913, PMCID: PMC6047927, DOI: 10.1007/s10461-018-2028-2.Peer-Reviewed Original ResearchConceptsChronic painPilot trialBrief Pain Inventory (BPI) total scorePain self-management interventionMedian session attendanceUsual care comparisonRandomized pilot trialSelf-management interventionsNovel behavioral interventionModerate painPain severityPreliminary efficacyIntervention groupSession attendanceCare comparisonsEligibility criteriaControl groupPainInterference ScaleBehavioral interventionsTrialsHIVPreliminary evidenceFull-scale trialEfficacy
2016
Drug Counselors’ Attitudes Toward Nonpharmacologic Treatments for Chronic Pain
Oberleitner LM, Beitel M, Schottenfeld RS, Kerns RD, Doucette C, Napoleone R, Liong C, Barry DT. Drug Counselors’ Attitudes Toward Nonpharmacologic Treatments for Chronic Pain. Journal Of Addiction Medicine 2016, 10: 34-39. PMID: 26690289, PMCID: PMC4733570, DOI: 10.1097/adm.0000000000000177.Peer-Reviewed Original ResearchConceptsChronic painNonpharmacologic treatmentsDrug counselorsNonpharmacologic pain treatmentsMethadone-maintained patientsInterdisciplinary pain managementMethadone maintenance treatmentVulnerable patient populationCognitive behavioral therapyNonpharmacologic interventionsPain managementPain treatmentPain interventionsMaintenance treatmentPatient populationPainPatientsHerbal medicineGroup interventionEfficacyInterventionTreatmentPerceived EfficacyTherapyUndertreatmentInitial development of patient-reported instrument assessing harm, efficacy, and misuse of long-term opioid therapy
Becker WC, Fiellin DA, Black AC, Kostovich CT, Kerns RD, Fraenkel L. Initial development of patient-reported instrument assessing harm, efficacy, and misuse of long-term opioid therapy. The Journal Of Rehabilitation Research And Development 2016, 53: 127-136. PMID: 27006339, PMCID: PMC4806533, DOI: 10.1682/jrrd.2014.11.0285.Peer-Reviewed Original ResearchConceptsLong-term opioid therapyPatient-reported instrumentOpioid therapyFurther item reductionIneffective medicationsClinical outcomesPrimary careFrequent reassessmentPatient comprehensionItem reductionGold standardEfficacyTherapyInterdisciplinary teamLevel checksCognitive interviewsMisuseHarmMedicationsPatients
2013
A Research Agenda for Enhancing Appropriate Opioid Prescribing in Primary Care
Becker WC, Fraenkel L, Kerns RD, Fiellin DA. A Research Agenda for Enhancing Appropriate Opioid Prescribing in Primary Care. Journal Of General Internal Medicine 2013, 28: 1364-1367. PMID: 23568187, PMCID: PMC3785661, DOI: 10.1007/s11606-013-2422-4.Peer-Reviewed Educational MaterialsConceptsOpioid prescribingLong-term opioid therapyMulti-modal treatment planAppropriate opioid prescribingOpioid analgesic therapyPatient-reported safetyEvidence-based algorithmOpioid therapyOptimize therapyAnalgesic therapyChronic painPotent medicationsInadequate efficacyPrimary careQuality improvement workPatient sufferingMild toxicityTreatment planScant dataTherapyPrescribingEfficacyPatientsOutcomesToxicityInstruments to assess patient‐reported safety, efficacy, or misuse of current opioid therapy for chronic pain: A systematic review
Becker WC, Fraenkel L, Edelman J, Holt SR, Glover J, Kerns RD, Fiellin DA. Instruments to assess patient‐reported safety, efficacy, or misuse of current opioid therapy for chronic pain: A systematic review. Pain 2013, 154: 905-916. PMID: 23601625, PMCID: PMC3683236, DOI: 10.1016/j.pain.2013.02.031.Peer-Reviewed Original ResearchConceptsPatient-reported safetyOpioid therapyChronic painInclusion criteriaSystematic reviewOngoing opioid therapyPsychometric testsLack of testingEligible studiesClinical practiceInitial searchStatistical significanceDiagnostic accuracy testingPainEfficacyTherapyEfficacy itemsContent expertsSafetyLimited assessmentReviewLiterature reviewGeneralizability limitationsFurther researchIndividual items
2010
Research design considerations for confirmatory chronic pain clinical trials: IMMPACT recommendations
Dworkin RH, Turk DC, Peirce-Sandner S, Baron R, Bellamy N, Burke LB, Chappell A, Chartier K, Cleeland CS, Costello A, Cowan P, Dimitrova R, Ellenberg S, Farrar JT, French JA, Gilron I, Hertz S, Jadad AR, Jay GW, Kalliomäki J, Katz NP, Kerns RD, Manning DC, McDermott MP, McGrath PJ, Narayana A, Porter L, Quessy S, Rappaport BA, Rauschkolb C, Reeve BB, Rhodes T, Sampaio C, Simpson DM, Stauffer JW, Stucki G, Tobias J, White RE, Witter J. Research design considerations for confirmatory chronic pain clinical trials: IMMPACT recommendations. Pain 2010, 149: 177-193. PMID: 20207481, DOI: 10.1016/j.pain.2010.02.018.Peer-Reviewed Original ResearchConceptsChronic pain clinical trialsPain clinical trialsClinical trialsPrimary efficacy analysisChronic pain trialsDemonstration of efficacyIMMPACT recommendationsResearch design considerationsAnalgesic effectPain trialsChronic painEfficacy analysisTypes of trialsConsensus meetingTreatment groupsNew interventionsTrue lackTrialsTrial phaseEfficacyMethodological weaknessesAssay sensitivityTreatmentSubstantial variabilityParticipant selection