2007
Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions
Corlett PR, Murray GK, Honey GD, Aitken MR, Shanks DR, Robbins TW, Bullmore ET, Dickinson A, Fletcher PC. Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions. Brain 2007, 130: 2387-2400. PMID: 17690132, PMCID: PMC3838942, DOI: 10.1093/brain/awm173.Peer-Reviewed Original ResearchConceptsDelusion formationDelusional beliefsPrediction error processingPrediction-error signallingPrediction error signalsAttentional allocationAssociative accountMaladaptive beliefsError processingAssociative learningNeurobiological theoriesBrain responsesCortex responsesIndividual's propensityBelief formationDelusionsBeliefsPrediction errorExtent of disruptionProcessingFMRILearningPsychosisExpectancyIndividualsFrom prediction error to psychosis: ketamine as a pharmacological model of delusions
Corlett PR, Honey GD, Fletcher PC. From prediction error to psychosis: ketamine as a pharmacological model of delusions. Journal Of Psychopharmacology 2007, 21: 238-252. PMID: 17591652, DOI: 10.1177/0269881107077716.Peer-Reviewed Original ResearchConceptsDelusion formationAssociative learning processesPrediction error signalsDevelopment of delusionsFormation of delusionsPre-psychotic periodAttentional disruptionAttentional disturbancesNeuropsychiatric modelsNeurobiological systemsPrediction errorExperience resultsLearning processIrrelevant detailsDelusionsError signalDrug ketaminePsychosisNumerous associationsPsychotic statesPerceptExpectationsPharmacological modelStimuliSymptom evolution
2006
Frontal Responses During Learning Predict Vulnerability to the Psychotogenic Effects of Ketamine: Linking Cognition, Brain Activity, and Psychosis
Corlett PR, Honey GD, Aitken MR, Dickinson A, Shanks DR, Absalom AR, Lee M, Pomarol-Clotet E, Murray GK, McKenna PJ, Robbins TW, Bullmore ET, Fletcher PC. Frontal Responses During Learning Predict Vulnerability to the Psychotogenic Effects of Ketamine: Linking Cognition, Brain Activity, and Psychosis. JAMA Psychiatry 2006, 63: 611-621. PMID: 16754834, DOI: 10.1001/archpsyc.63.6.611.Peer-Reviewed Original ResearchMeSH KeywordsAdultAssociation LearningBrief Psychiatric Rating ScaleCognition DisordersDelusionsDisease SusceptibilityDose-Response Relationship, DrugFemaleFrontal LobeHumansKetamineMagnetic Resonance ImagingMaleModels, TheoreticalPerceptual DisordersPlacebosProbabilityPsychiatric Status Rating ScalesPsychoses, Substance-InducedPsychotic DisordersConceptsDelusion formationPerceptual AberrationBrain activityError-dependent learningPharmacological functional magnetic resonanceAssociative learning taskFunctional magnetic resonance imagingAssociative learning processesDelusion-like beliefsFrontal cortical functionFunctional magnetic resonanceFull Scale IQUnderstanding of psychosisRight frontal cortexRight-handed volunteersNeurobiological accountsCognitive processesClinical Neuroscience InstituteFrontal activationAssociative learningFrontal responseBrain activationStructured Clinical InterviewLearning taskPsychotogenic effects
2004
Prediction Error during Retrospective Revaluation of Causal Associations in HumansfMRI Evidence in Favor of an Associative Model of Learning
CORLETT P, AITKEN M, DICKINSON A, SHANKS D, HONEY G, HONEY R, ROBBINS T, BULLMORE E, FLETCHER P. Prediction Error during Retrospective Revaluation of Causal Associations in HumansfMRI Evidence in Favor of an Associative Model of Learning. Neuron 2004, 44: 877-888. DOI: 10.1016/s0896-6273(04)00756-1.Peer-Reviewed Original ResearchPrediction Error during Retrospective Revaluation of Causal Associations in Humans fMRI Evidence in Favor of an Associative Model of Learning
Corlett P, Aitken M, Dickinson A, Shanks D, Honey G, Honey R, Robbins T, Bullmore E, Fletcher P. Prediction Error during Retrospective Revaluation of Causal Associations in Humans fMRI Evidence in Favor of an Associative Model of Learning. Neuron 2004, 44: 877-888. PMID: 15572117, DOI: 10.1016/j.neuron.2004.11.022.Peer-Reviewed Original ResearchMeSH KeywordsAdultAssociation LearningBrainBrain MappingCorpus StriatumFemaleHumansMagnetic Resonance ImagingMalePrefrontal CortexPsychological TheoryConceptsRetrospective revaluationPrefrontal cortexAssociative accountRight lateral PFC activationRight lateral prefrontal cortexLate brain responsesAssociative learning theoryLateral PFC activationLateral prefrontal cortexRight prefrontal cortexVentral striatal activationPrediction errorAssociative theoryPFC activationBrain responsesFunctional neuroimagingStriatal activationAssociative modelPC theoryAssociative viewLearning phenomenonLearning theoryContrast theoryLearningCues