2023
Excessive teleological thinking is driven by aberrant associations and not by failure of reasoning
Ongchoco J, Castiello S, Corlett P. Excessive teleological thinking is driven by aberrant associations and not by failure of reasoning. IScience 2023, 26: 107643. PMID: 37705957, PMCID: PMC10495659, DOI: 10.1016/j.isci.2023.107643.Peer-Reviewed Original ResearchAssociative learningTeleological thinkingCausal learning taskDelusion-like ideasFailure of reasoningCausal learningLearning taskLearningThinkingPrediction errorFundamental distinctionAberrant associationComputational modelingTeleological tendencyTaskReasoningTendencyDifferent instancesMeaningNew understandingObjectsDistinctionRelationshipEvents
2018
Delusions and Prediction Error
Corlett P. Delusions and Prediction Error. 2018, 35-66. DOI: 10.1007/978-3-319-97202-2_2.Peer-Reviewed Original ResearchAberrant prediction errorsPrediction error responsesPrediction errorCognitive neuroscienceParsimonious accountNeural mechanismsError responsesProblem of beliefProminent theoriesPredictive codingNovel predictionsError accountsDelusionsBridging TheoryPhenomenological dataBeliefsAdaptive fitnessNeuroscienceSingle factorTheoryBrainMindErrorAccountPrediction
2010
Toward a neurobiology of delusions
Corlett PR, Taylor JR, Wang X, Fletcher PC, Krystal JH. Toward a neurobiology of delusions. Progress In Neurobiology 2010, 92: 345-369. PMID: 20558235, PMCID: PMC3676875, DOI: 10.1016/j.pneurobio.2010.06.007.Peer-Reviewed Original ResearchConceptsFundamental brain mechanismsFronto-striatal circuitsTerms of cognitionPsychological processesBrain mechanismsComputational mechanismsCortical hierarchyPrediction errorSocial learningParietal cortexExternal worldBrain circuitsNeurobiological abnormalitiesNeurobiology of delusionsBrain functionHierarchical predictionBodily agencyDelusionsMemoryReinforcement learningPerceptionMental illnessTranslational understandingLearningCognition
2009
Why Do Delusions Persist?
Corlett PR, Krystal JH, Taylor JR, Fletcher PC. Why Do Delusions Persist? Frontiers In Human Neuroscience 2009, 3: 12. PMID: 19636384, PMCID: PMC2713737, DOI: 10.3389/neuro.09.012.2009.Peer-Reviewed Original Research
2007
Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions
Corlett PR, Murray GK, Honey GD, Aitken MR, Shanks DR, Robbins TW, Bullmore ET, Dickinson A, Fletcher PC. Disrupted prediction-error signal in psychosis: evidence for an associative account of delusions. Brain 2007, 130: 2387-2400. PMID: 17690132, PMCID: PMC3838942, DOI: 10.1093/brain/awm173.Peer-Reviewed Original ResearchConceptsDelusion formationDelusional beliefsPrediction error processingPrediction-error signallingPrediction error signalsAttentional allocationAssociative accountMaladaptive beliefsError processingAssociative learningNeurobiological theoriesBrain responsesCortex responsesIndividual's propensityBelief formationDelusionsBeliefsPrediction errorExtent of disruptionProcessingFMRILearningPsychosisExpectancyIndividualsSubstantia nigra/ventral tegmental reward prediction error disruption in psychosis
Murray G, Corlett P, Clark L, Pessiglione M, Blackwell A, Honey G, Jones P, Bullmore E, Robbins T, Fletcher P. Substantia nigra/ventral tegmental reward prediction error disruption in psychosis. Molecular Psychiatry 2007, 13: 267-276. PMID: 17684497, PMCID: PMC2564111, DOI: 10.1038/sj.mp.4002058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceCase-Control StudiesChoice BehaviorFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleModels, PsychologicalNeuropsychological TestsOxygenPhotic StimulationPsychiatric Status Rating ScalesPsychotic DisordersRewardSubstantia NigraVentral Tegmental AreaConceptsDopaminergic midbrainFunctional magnetic resonance imagingReward prediction errorHealthy control participantsPsychosis patientsNeutral stimuliMotivational salienceNeural responsesMental experienceRecent theoretical interestFirst-episode psychosis patientsPrediction errorConditioning experimentsControl participantsEpisode psychosis patientsPsychotic experiencesPathophysiology of schizophreniaPositive symptomsAbnormal physiological responsesMesolimbic activityMidbrain dopamine neuronsMagnetic resonance imagingDopamine dysfunctionDopamine systemDopamine neuronsFrom prediction error to psychosis: ketamine as a pharmacological model of delusions
Corlett PR, Honey GD, Fletcher PC. From prediction error to psychosis: ketamine as a pharmacological model of delusions. Journal Of Psychopharmacology 2007, 21: 238-252. PMID: 17591652, DOI: 10.1177/0269881107077716.Peer-Reviewed Original ResearchConceptsDelusion formationAssociative learning processesPrediction error signalsDevelopment of delusionsFormation of delusionsPre-psychotic periodAttentional disruptionAttentional disturbancesNeuropsychiatric modelsNeurobiological systemsPrediction errorExperience resultsLearning processIrrelevant detailsDelusionsError signalDrug ketaminePsychosisNumerous associationsPsychotic statesPerceptExpectationsPharmacological modelStimuliSymptom evolution
2004
Prediction Error during Retrospective Revaluation of Causal Associations in HumansfMRI Evidence in Favor of an Associative Model of Learning
CORLETT P, AITKEN M, DICKINSON A, SHANKS D, HONEY G, HONEY R, ROBBINS T, BULLMORE E, FLETCHER P. Prediction Error during Retrospective Revaluation of Causal Associations in HumansfMRI Evidence in Favor of an Associative Model of Learning. Neuron 2004, 44: 877-888. DOI: 10.1016/s0896-6273(04)00756-1.Peer-Reviewed Original ResearchPrediction Error during Retrospective Revaluation of Causal Associations in Humans fMRI Evidence in Favor of an Associative Model of Learning
Corlett P, Aitken M, Dickinson A, Shanks D, Honey G, Honey R, Robbins T, Bullmore E, Fletcher P. Prediction Error during Retrospective Revaluation of Causal Associations in Humans fMRI Evidence in Favor of an Associative Model of Learning. Neuron 2004, 44: 877-888. PMID: 15572117, DOI: 10.1016/j.neuron.2004.11.022.Peer-Reviewed Original ResearchConceptsRetrospective revaluationPrefrontal cortexAssociative accountRight lateral PFC activationRight lateral prefrontal cortexLate brain responsesAssociative learning theoryLateral PFC activationLateral prefrontal cortexRight prefrontal cortexVentral striatal activationPrediction errorAssociative theoryPFC activationBrain responsesFunctional neuroimagingStriatal activationAssociative modelPC theoryAssociative viewLearning phenomenonLearning theoryContrast theoryLearningCues