2025
Differing Pattern of Mismatch Negativity Responses in Clinical and Nonclinical Voice Hearers Challenge Predictive Coding Accounts of Psychosis
Erickson M, Bansal S, Li C, Waltz J, Corlett P, Gold J. Differing Pattern of Mismatch Negativity Responses in Clinical and Nonclinical Voice Hearers Challenge Predictive Coding Accounts of Psychosis. Biological Psychiatry Global Open Science 2025, 5: 100394. DOI: 10.1016/j.bpsgos.2024.100394.Peer-Reviewed Original ResearchHealthy comparison subjectsReduced mismatch negativityPrediction error signalsPositive symptomsMismatch negativityDeviant typesPredictive coding accountPresence of hallucinationsMismatch negativity paradigmAuditory memory tracesComparison subjectsCoding accountMemory tracesPsychiatric illnessMMN responseVoice hearersRepetitive positioningError signalDuration conditionsHallucinationsHigher-levelDMMNDifferent patternsSymptomsPSZ
2023
Using dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis
Fleming L, Lemonde A, Benrimoh D, Gold J, Taylor J, Malla A, Joober R, Iyer S, Lepage M, Shah J, Corlett P. Using dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis. Scientific Reports 2023, 13: 4841. PMID: 36964175, PMCID: PMC10039017, DOI: 10.1038/s41598-023-31909-w.Peer-Reviewed Original ResearchConceptsHallucinations/delusionsFirst-episode psychosisFirst-episode psychosis participantsEarly intervention programsPathophysiological mechanismsUnderlying pathophysiologyEpisode psychosisPsychotic illnessPsychotic symptomsPsychotic disordersSchizoaffective disorderAuditory hallucinationsPositive symptomsHallucination severityNegative symptomsSymptomsDisorganization symptomsIntervention programsHallucinationsIllnessPsychosis participantsPsychosisDelusionsDisordersParticipants
2020
Overweighting of Initial Motion Information Correlates With Severity of Positive Symptoms in Schizophrenia
Gold J, Bansal S, Erickson M, Waltz J, Corlett P. Overweighting of Initial Motion Information Correlates With Severity of Positive Symptoms in Schizophrenia. Biological Psychiatry 2020, 87: s207-s208. DOI: 10.1016/j.biopsych.2020.02.539.Peer-Reviewed Original ResearchPositive symptoms
2009
From drugs to deprivation: a Bayesian framework for understanding models of psychosis
Corlett PR, Frith CD, Fletcher PC. From drugs to deprivation: a Bayesian framework for understanding models of psychosis. Psychopharmacology 2009, 206: 515-530. PMID: 19475401, PMCID: PMC2755113, DOI: 10.1007/s00213-009-1561-0.Peer-Reviewed Original ResearchConceptsSymptoms of psychosisImportance of perceptionsProcessing of informationCognitive modelPrior expectanciesPerceptual AberrationModel of psychosisNeural circuitryInformation processingDifferent manipulationsPositive symptomsExperimental manipulationSerotonergic hallucinogensPerceptionPsychosisNew predictionsPsychotomimetic drugsUseful settingProcessingDistinctive effectsSymptomsInferenceNMDA receptor antagonistDistinct symptomsLearning
2007
Substantia nigra/ventral tegmental reward prediction error disruption in psychosis
Murray G, Corlett P, Clark L, Pessiglione M, Blackwell A, Honey G, Jones P, Bullmore E, Robbins T, Fletcher P. Substantia nigra/ventral tegmental reward prediction error disruption in psychosis. Molecular Psychiatry 2007, 13: 267-276. PMID: 17684497, PMCID: PMC2564111, DOI: 10.1038/sj.mp.4002058.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceCase-Control StudiesChoice BehaviorFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleModels, PsychologicalNeuropsychological TestsOxygenPhotic StimulationPsychiatric Status Rating ScalesPsychotic DisordersRewardSubstantia NigraVentral Tegmental AreaConceptsDopaminergic midbrainFunctional magnetic resonance imagingReward prediction errorHealthy control participantsPsychosis patientsNeutral stimuliMotivational salienceNeural responsesMental experienceRecent theoretical interestFirst-episode psychosis patientsPrediction errorConditioning experimentsControl participantsEpisode psychosis patientsPsychotic experiencesPathophysiology of schizophreniaPositive symptomsAbnormal physiological responsesMesolimbic activityMidbrain dopamine neuronsMagnetic resonance imagingDopamine dysfunctionDopamine systemDopamine neurons
2005
Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function
Honey G, Pomarol-Clotet E, Corlett P, Honey R, Mckenna P, Bullmore E, Fletcher P. Functional dysconnectivity in schizophrenia associated with attentional modulation of motor function. Brain 2005, 128: 2597-2611. PMID: 16183659, PMCID: PMC3838931, DOI: 10.1093/brain/awh632.Peer-Reviewed Original ResearchConceptsCognitive dysmetria hypothesisPatient groupAnterior cingulateFunctional MRIContinuous performance taskFunctional dysconnectivitySchizophrenia patientsPositive symptomsNegative symptomsMedial superior frontal gyrusThalamo-cortical circuitsDistinct symptom profilesSupplementary motor areaCases of schizophreniaSuperior frontal gyrusFunctional imaging studiesTask-related connectivityGroups of subjectsIllness onsetControl subjectsFunctional deficitsMotor functionHealthy volunteersMotor areaFundamental abnormality