2008
Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole
Banasr M, Chowdhury GM, Terwilliger R, Newton SS, Duman RS, Behar KL, Sanacora G. Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Molecular Psychiatry 2008, 15: 501-511. PMID: 18825147, PMCID: PMC3347761, DOI: 10.1038/mp.2008.106.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAnimalsAvoidance LearningBehavioral SymptomsDepressionDisease Models, AnimalFood PreferencesGene Expression RegulationGlial Fibrillary Acidic ProteinGlutamic AcidIsotopesMagnetic Resonance SpectroscopyMaleNeurogliaNeuroprotective AgentsPrefrontal CortexRadionuclide ImagingRatsRats, Sprague-DawleyRiluzoleRNA, MessengerStatistics, NonparametricStress, PsychologicalSucroseSweetening AgentsConceptsChronic unpredictable stressPrefrontal cortexGlial dysfunctionGlial functionBehavioral deficitsDrug riluzoleOpen-label clinical trialMRNA expressionAmino acid neurotransmissionAntidepressant drug developmentDepressive-like behaviorPathophysiology of depressionEffects of riluzoleGlial cell metabolismMajor depressive disorderRat prefrontal cortexGFAP mRNA expressionProtein mRNA expressionNeurotransmitter system abnormalitiesGlia pathologyGlial pathologyRiluzole treatmentAntidepressant actionChronic treatmentGlutamate release
2007
Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase‐deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling
Chowdhury GM, Gupta M, Gibson KM, Patel AB, Behar KL. Altered cerebral glucose and acetate metabolism in succinic semialdehyde dehydrogenase‐deficient mice: evidence for glial dysfunction and reduced glutamate/glutamine cycling. Journal Of Neurochemistry 2007, 103: 2077-2091. PMID: 17854388, DOI: 10.1111/j.1471-4159.2007.04887.x.Peer-Reviewed Original ResearchMeSH KeywordsAcetatesAmino AcidsAnimalsAnimals, NewbornBlood GlucoseCarbon IsotopesCerebral CortexGamma-Aminobutyric AcidGlutamate-Ammonia LigaseGlutamic AcidGlutamineImage Processing, Computer-AssistedMagnetic Resonance SpectroscopyMiceMice, KnockoutNeurogliaSodium OxybateSuccinate-Semialdehyde DehydrogenaseTime FactorsConceptsSSADH deficiencyLevels of GABAGlutamate/glutamine cyclingSuccinic semialdehyde dehydrogenase‐deficient miceGlutamine-C4Cerebral metabolismCerebral glucoseCortical extractsGlial dysfunctionIntraperitoneal infusionSuccinic semialdehyde dehydrogenaseGABA-C2Excessive elevationNeurotransmitter glutamateGABA synthesisGABAMiceGHBGlutamateGlutamine metabolismAspartate C3GliaCortexGlutamine cyclingGlial substrate