1998
Pretreatment plasma HVA predicts neuroleptic response in manic psychosis
Mazure C, Bowers M. Pretreatment plasma HVA predicts neuroleptic response in manic psychosis. Journal Of Affective Disorders 1998, 48: 83-86. PMID: 9495606, DOI: 10.1016/s0165-0327(97)00159-6.Peer-Reviewed Original ResearchAcute Neuroleptic Treatment in Elderly Patients Without Dementia
Mazure C, Nelson J, Jatlow P, Bowers M. Acute Neuroleptic Treatment in Elderly Patients Without Dementia. American Journal Of Geriatric Psychiatry 1998, 6: 221-229. PMID: 9659955, DOI: 10.1097/00019442-199800630-00005.Peer-Reviewed Original ResearchConceptsNon-elderly adultsElderly patientsNeuroleptic treatmentAcute responseLow dosesLow-dose neuroleptic treatmentAcute neuroleptic treatmentAdverse effectsHigh-dose treatmentLow-dose treatmentDrug blood levelsPrimary psychotic illnessInitial doseBlood levelsPsychotic illnessEffective treatmentPatientsDose ratioLonger durationTreatmentLower ratesDosesAdultsResponseNeuroleptics
1995
Assessment of extrapyramidal symptoms during acute neuroleptic treatment.
Mazure CM, Cellar JS, Bowers MB, Nelson JC, Takeshita J, Zigun B. Assessment of extrapyramidal symptoms during acute neuroleptic treatment. The Journal Of Clinical Psychiatry 1995, 56: 94-100. PMID: 7883736.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdultAkathisia, Drug-InducedAntipsychotic AgentsBasal Ganglia DiseasesDystoniaFemaleHumansMaleMiddle AgedParkinson Disease, SecondaryPhysical ExaminationPsychiatric Status Rating ScalesPsychotic DisordersReproducibility of ResultsSeverity of Illness IndexStatistics, NonparametricConceptsExtrapyramidal symptomsDrug regimenAcute treatmentNeuroleptic drugsSide effectsInterrater reliabilityAcute neuroleptic treatmentPatient's drug regimenExtrapyramidal Symptoms ScaleExtrapyramidal side effectsTraditional neuroleptic drugsLow nonsignificant correlationsRatings of symptomsAcute administrationNeuroleptic treatmentAdverse reactionsParkinson's diseasePsychotic symptomsSymptom ScalePsychotic patientsEPS scaleSymptomsClinician ratersCliniciansInterrater agreement
1992
Drug-responsive symptoms during early neuroleptic treatment
Mazure C, Nelson J, Jatlow P, Bowers M. Drug-responsive symptoms during early neuroleptic treatment. Psychiatry Research 1992, 41: 147-154. PMID: 1574541, DOI: 10.1016/0165-1781(92)90106-d.Peer-Reviewed Original ResearchConceptsDrug responseEarly drug responseDays of treatmentIdentification of symptomsNeuroleptic treatmentSerum concentrationsNeuroleptic drugsNeurochemical mechanismsPositive symptomsSymptomsProgressive phaseDrug actionConceptual disorganizationMultiple regression analysisRegression analysisTreatmentPsychosisSeverityHallucinationsResponse
1991
Plasma free homovanillic acid (HVA) as a predictor of clinical response in acute psychosis
Mazure C, Nelson J, Jatlow P, Bowers M. Plasma free homovanillic acid (HVA) as a predictor of clinical response in acute psychosis. Biological Psychiatry 1991, 30: 475-482. PMID: 1932395, DOI: 10.1016/0006-3223(91)90309-a.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdolescentAdultBipolar DisorderChromatography, High Pressure LiquidDepressive DisorderDose-Response Relationship, DrugDrug Administration ScheduleFemaleFollow-Up StudiesHomovanillic AcidHumansMaleMethoxyhydroxyphenylglycolMiddle AgedPerphenazinePrognosisProspective StudiesPsychiatric Status Rating ScalesPsychotic DisordersSchizophreniaSchizophrenic PsychologyConceptsPlasma homovanillic acidHomovanillic acidFree homovanillic acidClinical responseEarly clinical responsePlasma-free homovanillic acidUseful clinical predictorClinical predictorsNeuroleptic treatmentAcute psychosisDopamine metabolismNoradrenergic functioningMethoxyhydroxyphenylglycolFavorable responsePsychotic inpatientsGood responseSignificant decline