2023
Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Grilo C, Lydecker J, Jastreboff A, Pittman B, McKee S. Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial. Obesity 2023, 31: 2762-2773. PMID: 37751990, PMCID: PMC10600891, DOI: 10.1002/oby.23898.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderObesity statusLogistic regressionWeight lossPlacebo-controlled trialWeight loss outcomesPrevalent psychiatric disordersEvidence-based treatmentsPost-treatment assessmentBinge-eating frequencyGreater percentage weight lossMedication outcomesRemission ratePharmacological optionsPlaceboBupropionPsychiatric disordersPercentage weight lossMixed modelsDisordersObesityPatientsSignificant reductionWeight reductionImprovements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity
Yurkow S, Ivezaj V, Grilo C. Improvements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity. International Journal Of Eating Disorders 2023, 56: 2074-2083. PMID: 37530200, PMCID: PMC10834830, DOI: 10.1002/eat.24035.Peer-Reviewed Original ResearchConceptsCardiovascular disease risk factorsModest weight lossDisease risk factorsBinge-eating disorderPlasma glucoseRisk factorsWeight lossLifestyle changesBehavioral lifestyle changesCardiovascular disease riskWeight loss treatmentSignificant improvementRelated lifestyle changesTotal cholesterolPotential health benefitsHeart ratePatientsObesityDisease riskHbA1cHealth benefitsDisordersTriglyceridesTreatmentPosttreatmentBinge-Eating Disorder Interventions: Review, Current Status, and Implications
Grilo C, Juarascio A. Binge-Eating Disorder Interventions: Review, Current Status, and Implications. Current Obesity Reports 2023, 12: 406-416. PMID: 37439970, PMCID: PMC10528223, DOI: 10.1007/s13679-023-00517-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultBehavior TherapyBinge-Eating DisorderBulimiaHumansPsychotherapyTreatment OutcomeWeight LossConceptsPsychological treatmentSpecific psychological treatmentsEating-disorder psychopathologyEvidence-based treatmentsAdditional pharmacological optionsDisorder interventionsSerious psychiatric problemsBehavioral lifestyle interventionScalable interventionsEffective interventionsFuture researchCBTPsychiatric problemsBingeMixed outcomesInterventionCBTgshModest weight lossRecent findingsResearchPsychopathologyShameLifestyle interventionPharmacological optionsSubstantial morbidityNaltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial
Grilo C, Lydecker J, Gueorguieva R. Naltrexone plus bupropion combination medication maintenance treatment for binge-eating disorder following successful acute treatments: randomized double-blind placebo-controlled trial. Psychological Medicine 2023, 53: 7775-7784. PMID: 37366017, PMCID: PMC10751383, DOI: 10.1017/s0033291723001800.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderBinge-eating remissionAcute treatmentMaintenance treatmentBinge-eating frequencyDouble-blind placebo-controlled trialBehavioral weight loss therapyWeight lossCo-occurring obesitySuccessful acute treatmentPlacebo-controlled trialWeight loss therapySignificant additional weight lossSingle-site trialAdditional weight lossAcute efficacyRemission rateAdult patientsComorbid obesityBupropionInitial interventionPosttreatment assessmentRespondersPlaceboPredictors of early weight loss in post‐bariatric surgery patients receiving adjunctive behavioural treatments for loss‐of‐control eating
Smith C, Dilip A, Ivezaj V, Duffy A, Grilo C. Predictors of early weight loss in post‐bariatric surgery patients receiving adjunctive behavioural treatments for loss‐of‐control eating. Clinical Obesity 2023, 13: e12603. PMID: 37257889, PMCID: PMC10524670, DOI: 10.1111/cob.12603.Peer-Reviewed Original ResearchConceptsEarly weight lossAdjunctive behavioral treatmentsPost-bariatric surgery patientsEarly weight changeBaseline patient characteristicsSurgery-related variablesMonths of treatmentWeight lossBehavioral treatmentPatient characteristicsSurgery patientsFirst monthWeight changeTime of surgeryWeight gain groupEating-disorder psychopathologyBariatric surgeryMost patientsAdjunctive treatmentBlack patientsPercent weight lossPsychiatric comorbidityClinical variablesTreatment trialsPatientsPsychiatric comorbidity as a prospective predictor of long-term weight and psychosocial outcomes after bariatric surgery
Ivezaj V, Dilip A, Grilo C. Psychiatric comorbidity as a prospective predictor of long-term weight and psychosocial outcomes after bariatric surgery. General Hospital Psychiatry 2023, 83: 51-58. PMID: 37099869, DOI: 10.1016/j.genhosppsych.2023.03.005.Peer-Reviewed Original ResearchConceptsEating Disorder Examination-Bariatric Surgery VersionLong-term weight outcomesPost-bariatric surgeryPsychiatric comorbidityEating-disorder psychopathologyBariatric surgeryWeight outcomesMonths post-bariatric surgeryMini International Neuropsychiatric InterviewWeight loss outcomesCurrent psychiatric disorderCurrent psychiatric comorbidityInternational Neuropsychiatric InterviewPsychosocial functioning outcomesLong-term weightBeck Depression InventoryPoor psychosocial functioningPrognostic significanceProspective studyBariatric populationNeuropsychiatric InterviewClinical significanceComorbiditiesLoss outcomesPsychiatric disordersPredictors and significance of rapid response to behaviorally based treatment of binge eating disorder
Yurkow S, Ivezaj V, Grilo C. Predictors and significance of rapid response to behaviorally based treatment of binge eating disorder. Obesity 2023, 31: 390-398. PMID: 36623872, PMCID: PMC9877118, DOI: 10.1002/oby.23648.Peer-Reviewed Original ResearchMeSH KeywordsBinge-Eating DisorderBulimiaCognitive Behavioral TherapyHumansPrognosisTreatment OutcomeWeight LossConceptsDemographic featuresTreatment attitudesWeight lossFourth treatment weekWeight loss outcomesPsychiatric variablesSuperior clinical outcomesWeight loss treatmentTreatment of bingeClinical severity variablesClinical outcomesPrognostic significanceTreatment weekClinical trialsBaseline predictorsLoss outcomesLoss treatmentPosttreatment outcomesBinge eatingIndependent assessorsBingeSeverity variablesDisordersPatientsTreatment
2018
Early weight loss predicts weight loss treatment response regardless of binge‐eating disorder status and pretreatment weight change
Barnes RD, Ivezaj V, Pittman BP, Grilo CM. Early weight loss predicts weight loss treatment response regardless of binge‐eating disorder status and pretreatment weight change. International Journal Of Eating Disorders 2018, 51: 558-564. PMID: 29637592, PMCID: PMC6002900, DOI: 10.1002/eat.22860.Peer-Reviewed Original ResearchConceptsEarly weight lossWeight loss treatmentBinge-eating disorderLoss treatmentWeight lossBed statusWeight loss treatment outcomesOverweight/obesityWeight loss trialAverage weight lossWeight-related variablesPrognostic significancePrimary careTreatment outcomesTreatment responseLoss trialWeight trajectoriesTreatment studiesDisorder statusWeight changeOutcomesTreatmentIndividual responsesStatusPositive outcomes
2017
Examining motivational interviewing plus nutrition psychoeducation for weight loss in primary care
Barnes RD, Ivezaj V, Martino S, Pittman BP, Paris M, Grilo CM. Examining motivational interviewing plus nutrition psychoeducation for weight loss in primary care. Journal Of Psychosomatic Research 2017, 104: 101-107. PMID: 29275778, PMCID: PMC5774024, DOI: 10.1016/j.jpsychores.2017.11.013.Peer-Reviewed Original ResearchConceptsBinge-eating disorderNutrition psychoeducationMotivational interviewingUsual careAttention control conditionWeight lossPrimary careBasic nutrition informationOverweight/obesityModerate weight lossPsychological improvementPsychoeducationMore weight lossMixed model analysisMixed-model analysisPrognostic significanceTreatment completionScalable combinationCurrent studyPercentage weight lossParticipantsBed statusNutrition informationCareGreater improvementBack to Basics? No Weight Loss from Motivational Interviewing Compared to Nutrition Psychoeducation at One‐Year Follow‐Up
Barnes RD, Ivezaj V, Martino S, Pittman BP, Grilo CM. Back to Basics? No Weight Loss from Motivational Interviewing Compared to Nutrition Psychoeducation at One‐Year Follow‐Up. Obesity 2017, 25: 2074-2078. PMID: 29086484, PMCID: PMC5705439, DOI: 10.1002/oby.21972.Peer-Reviewed Original ResearchConceptsWeight loss interventionPrimary careBinge-eating disorderWeight lossNutrition psychoeducationLoss interventionSecondary end point analysisWeight loss 12 monthsAttention-controlled comparisonMotivational interviewingMIC patientsEnd-point analysisTreatment conclusionOne-yearBed statusSmall effect sizesCareMonthsPatientsInterventionEffect sizeTreatmentPsychoeducationLong-term impactMixed modelsPsychological and Behavioral Treatments for Binge-Eating Disorder.
Grilo CM. Psychological and Behavioral Treatments for Binge-Eating Disorder. The Journal Of Clinical Psychiatry 2017, 78 Suppl 1: 20-24. PMID: 28125175, DOI: 10.4088/jcp.sh16003su1c.04.Peer-Reviewed Original ResearchConceptsBinge-eating disorderBehavioral treatmentBehavioral weight loss therapyCognitive behavioral therapyBinge Eating DisorderBehavioral treatment optionsInterpersonal psychotherapyIntervention protocolBetter outcomesSignificant predictorsWeight lossModest weight lossWeight loss therapyBody shapeReliable predictorTreatment outcomesLoss therapyTreatment optionsDisordersInterventionModeratorPredictorsPsychotherapyPatientsTherapy
2016
Loss-of-control eating following sleeve gastrectomy surgery
Ivezaj V, Kessler EE, Lydecker JA, Barnes RD, White MA, Grilo CM. Loss-of-control eating following sleeve gastrectomy surgery. Surgery For Obesity And Related Diseases 2016, 13: 392-398. PMID: 27913121, PMCID: PMC5357454, DOI: 10.1016/j.soard.2016.09.028.Peer-Reviewed Original ResearchConceptsSleeve gastrectomy surgeryGastrectomy surgeryWeight lossEating Disorder Examination-Bariatric Surgery VersionPoorer weight loss outcomesBED criteriaLower percent weight lossPoor weight lossWeight loss outcomesBody mass indexEating-disorder psychopathologyBinge-eating disorderRegular compensatory behaviorsCurrent mean ageUnited States METHODSBariatric surgeryPostoperative lossMass indexPercent weight lossMean ageMonths postsurgeryPoor outcomeLoss outcomesGreater severitySurgeryExamining binge‐eating disorder and food addiction in adults with overweight and obesity
Ivezaj V, White MA, Grilo CM. Examining binge‐eating disorder and food addiction in adults with overweight and obesity. Obesity 2016, 24: 2064-2069. PMID: 27558207, PMCID: PMC5039112, DOI: 10.1002/oby.21607.Peer-Reviewed Original ResearchConceptsOverweight/obesityBinge-eating disorderFood addictionFA criteriaPresence of BEDControl groupBody mass indexHealth-related behaviorsHigher depression scoresSubgroup of adultsMass indexDepression scoresObesityWeb-based surveyBED criteriaFA groupGreater pathologyOverweightPathologyDisordersAdultsGroupMost measuresAddictionIndividualsCombining Pharmacological and Psychological Treatments for Binge Eating Disorder: Current Status, Limitations, and Future Directions
Grilo CM, Reas DL, Mitchell JE. Combining Pharmacological and Psychological Treatments for Binge Eating Disorder: Current Status, Limitations, and Future Directions. Current Psychiatry Reports 2016, 18: 55. PMID: 27086316, DOI: 10.1007/s11920-016-0696-z.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyBinge Eating DisorderFuture treatment researchPsychological treatmentBehavioral therapyRecurrent bingeEating DisordersCompensatory behaviorsTreatment researchPharmacological treatmentHeightened levelsBehavioral weight loss interventionFuture researchWeight loss interventionLimited researchCurrent clinical practiceBingeCertain medicationsLoss interventionFuture directionsBWLClinical practiceWeight controlDisordersSuperior outcomesFood Thought Suppression Inventory: Test–retest reliability and relationship to weight loss treatment outcomes
Barnes RD, Ivezaj V, Grilo CM. Food Thought Suppression Inventory: Test–retest reliability and relationship to weight loss treatment outcomes. Eating Behaviors 2016, 22: 93-95. PMID: 27112114, PMCID: PMC5161461, DOI: 10.1016/j.eatbeh.2016.04.001.Peer-Reviewed Original ResearchConceptsFood Thought Suppression InventoryWeight loss treatmentBinge-eating episodesTest-retest reliabilityLoss treatmentWeight loss treatment outcomesWeight lossWeight loss goalsOriginal body weightWeek test-retest reliabilityPercent weight lossPrimary careTreatment outcomesIntra-class correlationBody weightBaselineTreatmentScoresEpisodesParticipantsPost assessmentHigh levelsBinge
2015
Pharmacological treatment of binge eating disorder: update review and synthesis
Reas DL, Grilo CM. Pharmacological treatment of binge eating disorder: update review and synthesis. Expert Opinion On Pharmacotherapy 2015, 16: 1463-1478. PMID: 26044518, PMCID: PMC4491373, DOI: 10.1517/14656566.2015.1053465.Peer-Reviewed Original ResearchConceptsCertain medicationsWeight lossDifferent medication classesOverview of pharmacotherapyMedical comorbiditiesMedication classesMinimal weight lossFirst medicationPharmacological treatmentRecurrent bingeLong-term effectsMedicationsSuperior outcomesMental disordersPharmacotherapyEvidence baseDisorder diagnosisStatistical ManualBingePhase IIIDisordersInclusion requirementsTrialsCombination approachRCTsPrognostic Significance of Depressive Symptoms on Weight Loss and Psychosocial Outcomes Following Gastric Bypass Surgery: A Prospective 24-Month Follow-Up Study
White MA, Kalarchian MA, Levine MD, Masheb RM, Marcus MD, Grilo CM. Prognostic Significance of Depressive Symptoms on Weight Loss and Psychosocial Outcomes Following Gastric Bypass Surgery: A Prospective 24-Month Follow-Up Study. Obesity Surgery 2015, 25: 1909-1916. PMID: 25720515, PMCID: PMC4551611, DOI: 10.1007/s11695-015-1631-9.Peer-Reviewed Original ResearchConceptsGastric bypass surgeryPostoperative depressive symptomsElevated depressive symptomsDepressive symptomsBypass surgeryWeight outcomesPrognostic significanceDisorder psychopathologyLong-term weight outcomesWeight lossPoorer weight outcomesPreoperative depressive symptomsBariatric surgery patientsWeight loss outcomesSignificant depressive symptomsMethodsThree hundred fiftyQuality of lifeBeck Depression InventorySurgery patientsBattery of assessmentsHundred fiftyLoss outcomesBackgroundThis studySurgeryClinical attention
2014
Comparing weight gain in the year prior to treatment for overweight and obese patients with and without binge eating disorder in primary care
Ivezaj V, Kalebjian R, Grilo CM, Barnes RD. Comparing weight gain in the year prior to treatment for overweight and obese patients with and without binge eating disorder in primary care. Journal Of Psychosomatic Research 2014, 77: 151-154. PMID: 25077857, PMCID: PMC4118055, DOI: 10.1016/j.jpsychores.2014.05.006.Peer-Reviewed Original ResearchConceptsObese patientsBED patientsBinge-eating frequencyWeight gainPrimary careWeight changeCurrent weightGreater eating-disorder psychopathologyNBO patientsWeight change trajectoriesPrimary care physiciansWeight loss treatmentBeck Depression Inventory-IIFurther weight gainEating-disorder psychopathologyRapid weight gainEating Disorder ExaminationCare physiciansWeight historySelf-report questionnairesOverall groupDepression scoresIndependent significant contributionPatientsOverweightCurrent and emerging drug treatments for binge eating disorder
Reas DL, Grilo CM. Current and emerging drug treatments for binge eating disorder. Expert Opinion On Emerging Drugs 2014, 19: 99-142. PMID: 24460483, PMCID: PMC4026932, DOI: 10.1517/14728214.2014.879291.Peer-Reviewed Original ResearchConceptsPsychological interventionsDisorder psychopathologyWeight lossCognitive behavioral therapyCertain medicationsBinge Eating DisorderBehavioral weight lossCombination of medicationsEating DisordersBingeDrug treatmentLong-term effectsMedicationsAssociated depressionTreatment studiesPsychopathologyBED outcomesPhase IIInterventionOutcomesDepressionTrialsDisordersRemissionPharmacotherapy
2011
Cognitive–Behavioral Therapy, Behavioral Weight Loss, and Sequential Treatment for Obese Patients With Binge-Eating Disorder: A Randomized Controlled Trial
Grilo CM, Masheb RM, Wilson GT, Gueorguieva R, White MA. Cognitive–Behavioral Therapy, Behavioral Weight Loss, and Sequential Treatment for Obese Patients With Binge-Eating Disorder: A Randomized Controlled Trial. Journal Of Consulting And Clinical Psychology 2011, 79: 675-685. PMID: 21859185, PMCID: PMC3258572, DOI: 10.1037/a0025049.Peer-Reviewed Original ResearchConceptsPercent BMI lossBehavioral weight lossBinge-eating disorderCognitive behavioral therapyBMI lossObese patientsWeight lossBinge-eating remissionAlternative treatment optionBinge Eating DisorderRemission rateControlled TrialsTreatment optionsMixed model analysisBehavioral therapyPatientsManualized treatmentAssessment pointsBingeRemissionGreater reductionTreatmentTherapySequential treatmentDisorders