2023
Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial
Grilo C, Lydecker J, Jastreboff A, Pittman B, McKee S. Naltrexone/bupropion for binge‐eating disorder: A randomized, double‐blind, placebo‐controlled trial. Obesity 2023, 31: 2762-2773. PMID: 37751990, PMCID: PMC10600891, DOI: 10.1002/oby.23898.Peer-Reviewed Original ResearchConceptsNaltrexone/bupropionBinge-eating disorderObesity statusLogistic regressionWeight lossPlacebo-controlled trialWeight loss outcomesPrevalent psychiatric disordersEvidence-based treatmentsPost-treatment assessmentBinge-eating frequencyGreater percentage weight lossMedication outcomesRemission ratePharmacological optionsPlaceboBupropionPsychiatric disordersPercentage weight lossMixed modelsDisordersObesityPatientsSignificant reductionWeight reductionImprovements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity
Yurkow S, Ivezaj V, Grilo C. Improvements in cardiovascular disease risk factors associated with modest weight loss following treatment in patients with binge‐eating disorder and obesity. International Journal Of Eating Disorders 2023, 56: 2074-2083. PMID: 37530200, PMCID: PMC10834830, DOI: 10.1002/eat.24035.Peer-Reviewed Original ResearchConceptsCardiovascular disease risk factorsModest weight lossDisease risk factorsBinge-eating disorderPlasma glucoseRisk factorsWeight lossLifestyle changesBehavioral lifestyle changesCardiovascular disease riskWeight loss treatmentSignificant improvementRelated lifestyle changesTotal cholesterolPotential health benefitsHeart ratePatientsObesityDisease riskHbA1cHealth benefitsDisordersTriglyceridesTreatmentPosttreatment
2018
Loss-of-control eating after bariatric/sleeve gastrectomy surgery: Similar to binge-eating disorder despite differences in quantities
Ivezaj V, Barnes RD, Cooper Z, Grilo CM. Loss-of-control eating after bariatric/sleeve gastrectomy surgery: Similar to binge-eating disorder despite differences in quantities. General Hospital Psychiatry 2018, 54: 25-30. PMID: 30056316, PMCID: PMC6245943, DOI: 10.1016/j.genhosppsych.2018.07.002.Peer-Reviewed Original ResearchConceptsSleeve gastrectomy surgeryBinge-eating disorderGastrectomy surgeryBinge Eating DisorderClinical featuresPatient groupControl eatingOW/OBOverweight/obesityBody mass indexRelevant patient groupsMass indexDepressive symptomsSurgeryPast monthBED groupWeight concernsWeekly lossDisordersCareful assessmentObesityOnly groupQuantity of foodComparable levelsEatingParents have both implicit and explicit biases against children with obesity
Lydecker JA, O’Brien E, Grilo CM. Parents have both implicit and explicit biases against children with obesity. Journal Of Behavioral Medicine 2018, 41: 784-791. PMID: 29728951, PMCID: PMC6209524, DOI: 10.1007/s10865-018-9929-4.Peer-Reviewed Original ResearchConceptsImplicit weight biasWeight biasChild variablesExplicit biasChild psychosocial functioningExplicit weight biasExplicit biasesChildren's resiliencePsychosocial functioningStigmatizing environmentsImplicit biasOverweight/obesityWeight discriminationParentsChildrenBiasResilienceChild healthObesityFunctioningClinical researchYouthBiasesHealthLess biasComparing men and women with binge‐eating disorder and co‐morbid obesity
Lydecker JA, Grilo CM. Comparing men and women with binge‐eating disorder and co‐morbid obesity. International Journal Of Eating Disorders 2018, 51: 411-417. PMID: 29493793, PMCID: PMC5980708, DOI: 10.1002/eat.22847.Peer-Reviewed Original ResearchConceptsBody mass indexBinge-eating disorderEating-disorder psychopathologyBinge-eating episodesBinge-eating behaviorClinical presentationResearch cliniciansHigher body mass indexCo-morbid obesityDSM-IV disordersStructured Clinical InterviewEating Disorder Examination interviewAge of onsetBinge-eating frequencyRace/ethnicityMass indexBED diagnosisClinical InterviewYounger ageObesityExamination interviewWomenMenAgeDisorders
2017
“I only watch for the commercials”: Messages about weight, eating and race in Super Bowl advertisements
Lydecker JA, Izzo A, Spielberger G, Grilo CM. “I only watch for the commercials”: Messages about weight, eating and race in Super Bowl advertisements. International Journal Of Clinical Practice 2017, 71: e13026. PMID: 28941009, PMCID: PMC5728649, DOI: 10.1111/ijcp.13026.Peer-Reviewed Original ResearchEvaluation of a web-based cognitive behavioral smoking cessation treatment for overweight/obese smokers
White MA, Ivezaj V, Grilo CM. Evaluation of a web-based cognitive behavioral smoking cessation treatment for overweight/obese smokers. Journal Of Health Psychology 2017, 24: 1796-1806. PMID: 28810442, DOI: 10.1177/1359105317701560.Peer-Reviewed Original ResearchConceptsSmoking cessation treatmentCessation treatmentObese smokersCognitive-behavioral treatmentBehavioral treatmentCognitive-behavioral smoking cessation treatmentBehavioral smoking cessation treatmentNicotine replacement therapyOverweight/obesityCessation ratesReplacement therapyRegular smokersStandard treatmentHealth educationLarger studySmokersPerson assessmentPilot studyCommunity volunteersTreatmentLess weightKey outcomesParticipantsObesityTherapy
2016
Perceived weight discrimination and chronic medical conditions in adults with overweight and obesity
Udo T, Purcell K, Grilo CM. Perceived weight discrimination and chronic medical conditions in adults with overweight and obesity. International Journal Of Clinical Practice 2016, 70: 1003-1011. PMID: 28032427, PMCID: PMC5215793, DOI: 10.1111/ijcp.12902.Peer-Reviewed Original ResearchConceptsChronic medical conditionsStressful life eventsMedical conditionsObese adultsPhysical activityMajor chronic medical conditionsWeight discriminationOverweight/obese adultsLife eventsAcute stressful life eventsSociodemographic variablesOverweight/obesityPerceived Weight DiscriminationMultiple logistic regressionGender-stratified analysesDifferent medical conditionsSocioeconomic burdenMyocardial infarctionHigh cholesterolCardiac conditionsStomach ulcersLogistic regressionRelated conditionsObesityHealth effectsChildren of parents with BED have more eating behavior disturbance than children of parents with obesity or healthy weight
Lydecker JA, Grilo CM. Children of parents with BED have more eating behavior disturbance than children of parents with obesity or healthy weight. International Journal Of Eating Disorders 2016, 50: 648-656. PMID: 27859458, PMCID: PMC5429220, DOI: 10.1002/eat.22648.Peer-Reviewed Original ResearchConceptsBinge-eating disorderChild weightChildren's bingeEating-disorder psychopathologyHigher child weightCross-sectional findingsChild overweightProspective confirmationChildren's eatingChild feedingChild overeatingDietary restrictionObesityClinical interventionsPrevention effortsEating Disorder BehaviorsDisordersBingePreliminary evidencePotential factorsEatingCurrent studyLimited literatureCore featuresOBPreferred descriptions for loss of control while eating and weight among patients with binge eating disorder
Roberto CA, Galbraith K, Lydecker JA, Ivezaj V, Barnes RD, White MA, Grilo CM. Preferred descriptions for loss of control while eating and weight among patients with binge eating disorder. Psychiatry Research 2016, 246: 548-553. PMID: 27821368, PMCID: PMC5161684, DOI: 10.1016/j.psychres.2016.09.045.Peer-Reviewed Original ResearchExamining binge‐eating disorder and food addiction in adults with overweight and obesity
Ivezaj V, White MA, Grilo CM. Examining binge‐eating disorder and food addiction in adults with overweight and obesity. Obesity 2016, 24: 2064-2069. PMID: 27558207, PMCID: PMC5039112, DOI: 10.1002/oby.21607.Peer-Reviewed Original ResearchConceptsOverweight/obesityBinge-eating disorderFood addictionFA criteriaPresence of BEDControl groupBody mass indexHealth-related behaviorsHigher depression scoresSubgroup of adultsMass indexDepression scoresObesityWeb-based surveyBED criteriaFA groupGreater pathologyOverweightPathologyDisordersAdultsGroupMost measuresAddictionIndividualsWords will never hurt me? Preferred terms for describing obesity and binge eating
Lydecker JA, Galbraith K, Ivezaj V, White MA, Barnes RD, Roberto CA, Grilo CM. Words will never hurt me? Preferred terms for describing obesity and binge eating. International Journal Of Clinical Practice 2016, 70: 682-690. PMID: 27354290, PMCID: PMC4965320, DOI: 10.1111/ijcp.12835.Peer-Reviewed Original ResearchPerceived weight discrimination, childhood maltreatment, and weight gain in U.S. adults with overweight/obesity
Udo T, Grilo CM. Perceived weight discrimination, childhood maltreatment, and weight gain in U.S. adults with overweight/obesity. Obesity 2016, 24: 1366-1372. PMID: 27112217, DOI: 10.1002/oby.21474.Peer-Reviewed Original ResearchConceptsBody mass indexOverweight/obesityPerceived Weight DiscriminationChildhood maltreatmentWeight discriminationWeight gainNational Epidemiologic SurveyMental health issuesMass indexBMI increaseEpidemiologic SurveyClinical settingU.S. adultsRelated conditionsObesityPrevention effortsHealth issuesWeight lossSubsequent stressorsWeight changeWave 2 surveyWomenGreater likelihoodGreater increaseWave 1Randomized controlled trial testing behavioral weight loss versus multi-modal stepped-care treatment for binge eating disorder
Grilo C. Randomized controlled trial testing behavioral weight loss versus multi-modal stepped-care treatment for binge eating disorder. European Psychiatry 2016, 33: s163. DOI: 10.1016/j.eurpsy.2016.01.321.Peer-Reviewed Original ResearchStepped-care treatmentAnti-obesity medicationsRemission rateWeight lossBehavioral weight lossCo-morbid obesityStepped-care modelObese BED patientsSignificant time effectInitial respondersTreatment challengesBED patientsMedicationsMixed model analysisPatientsBingePlaceboMonthsObesityBWLTreatmentStructured interviewsCBTDisordersMixed models
2015
Cardiovascular disease risk reduction in patients with binge eating disorder and obesity: Randomized controlled trial of stepped-care versus standard behavioral weight loss
Grilo C. Cardiovascular disease risk reduction in patients with binge eating disorder and obesity: Randomized controlled trial of stepped-care versus standard behavioral weight loss. Atherosclerosis 2015, 241: e19. DOI: 10.1016/j.atherosclerosis.2015.04.081.Peer-Reviewed Original Research
2014
Factor structure and clinical utility of the Beck Depression Inventory in patients with binge eating disorder and obesity
Udo T, McKee SA, Grilo CM. Factor structure and clinical utility of the Beck Depression Inventory in patients with binge eating disorder and obesity. General Hospital Psychiatry 2014, 37: 120-125. PMID: 25537344, PMCID: PMC4361288, DOI: 10.1016/j.genhosppsych.2014.11.011.Peer-Reviewed Original ResearchConceptsBeck Depression InventoryObese patientsMood disordersClinical utilityDepression InventoryDisorder psychopathologyHigh negative predictive valueMajor depressive disorderNegative predictive valueTreatment-seeking obese patientsExcellent internal consistencyDepressive disorderSelf-report questionnairesDepression symptomsPredictive valuePatientsThree-factor structureScreening instrumentDisordersObesityVariable associationsInternal consistencyObesity stigmatization as the status quo: Structural considerations and prevalence among young adults in the U.S.
Ambwani S, Thomas KM, Hopwood CJ, Moss SA, Grilo CM. Obesity stigmatization as the status quo: Structural considerations and prevalence among young adults in the U.S. Eating Behaviors 2014, 15: 366-370. PMID: 25064282, DOI: 10.1016/j.eatbeh.2014.04.005.Peer-Reviewed Original ResearchConceptsNegative attitudesObesity stigmatizationDisorder featuresObese peopleU.S. adultsSelf-report questionnairesYoung U.S. adultsSuch negative attitudesLife challengesAdult responsesObese personsObese Persons ScalePersons ScaleStigmatizing attitudesHarsher judgmentsYoung adultsEndorsement ratesFuture researchMajor dimensionsPrevalenceSignificant healthObeseAttitudesObesityStigmatization
2013
Obesity bias in training: Attitudes, beliefs, and observations among advanced trainees in professional health disciplines
Puhl RM, Luedicke J, Grilo CM. Obesity bias in training: Attitudes, beliefs, and observations among advanced trainees in professional health disciplines. Obesity 2013, 22: 1008-1015. PMID: 24124078, PMCID: PMC3968226, DOI: 10.1002/oby.20637.Peer-Reviewed Original ResearchThe factor structure of the metabolic syndrome in obese individuals with binge eating disorder
Udo T, McKee SA, White MA, Masheb RM, Barnes RD, Grilo CM. The factor structure of the metabolic syndrome in obese individuals with binge eating disorder. Journal Of Psychosomatic Research 2013, 76: 152-157. PMID: 24439692, PMCID: PMC3953028, DOI: 10.1016/j.jpsychores.2013.10.007.Peer-Reviewed Original ResearchConceptsObese individualsMetabolic syndromeMetabolic measuresHigh-risk populationType II diabetesBlood pressurePatient groupExcess weightSubgroup analysisCardiovascular diseaseRisk populationsGlucose regulationTreatment studiesVARCLUS procedurePopulation studiesFactor structureSyndromeBingeDisordersMetSDiverse populationsFour-factor structureIndividualsStatistical Analysis SystemObesity
2011
Can food be addictive? Public health and policy implications
Gearhardt AN, Grilo CM, DiLeone RJ, Brownell KD, Potenza MN. Can food be addictive? Public health and policy implications. Addiction 2011, 106: 1208-1212. PMID: 21635588, PMCID: PMC3171738, DOI: 10.1111/j.1360-0443.2010.03301.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPublic health approachAddictive drugsHealth approachPublic health interventionsDiet-related diseasesDrugs of abuseFood-related problemsEconomic burdenFood-related diseasesHealth interventionsBehavioral effectsHyperpalatable foodsAddictive potentialRelated diseasesDiseaseAddictive substancesDrug addictionDrugsObesityAddictive processPublic healthStrong considerationHealthFoodImportant differences