2024
A Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder
Kiluk B, Benitez B, DeVito E, Frankforter T, LaPaglia D, O’Malley S, Nich C. A Digital Cognitive Behavioral Therapy Program for Adults With Alcohol Use Disorder. JAMA Network Open 2024, 7: e2435205. PMID: 39325452, PMCID: PMC11428014, DOI: 10.1001/jamanetworkopen.2024.35205.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismCognitive Behavioral TherapyConnecticutFemaleHumansMaleMiddle AgedTreatment OutcomeConceptsCognitive behavioral therapyDigital cognitive behavioral therapyAlcohol use disorderAlcohol useCBT programUse disorderCognitive behavioral therapy programCurrent alcohol use disorderTreatment-seeking adultsBehavioral therapy programEvidence-based treatmentsBaseline to 6-month follow-upRates of alcohol useReducing alcohol useTreatment periodRandomized clinical trialsBehavioral therapyOutpatient substancePercentage of daysOutpatient treatmentIntention-to-treat analysisIndividual counselingStudy periodFollow-upIntention-to-treat
2023
Distinct neural networks predict cocaine versus cannabis treatment outcomes
Lichenstein S, Kohler R, Ye F, Potenza M, Kiluk B, Yip S. Distinct neural networks predict cocaine versus cannabis treatment outcomes. Molecular Psychiatry 2023, 28: 3365-3372. PMID: 37308679, PMCID: PMC10713861, DOI: 10.1038/s41380-023-02120-0.Peer-Reviewed Original ResearchMeSH KeywordsCannabisCocaineCocaine-Related DisordersCognitive Behavioral TherapyHumansMaleOpioid-Related DisordersSubstance-Related DisordersTreatment OutcomeConceptsConnectome-based predictive modelingCognitive behavior therapyCognitive behavioral therapySubstance use disordersCannabis abstinenceNeural mechanismsBehavior therapyDistinct neural networksComputer-based trainingCannabis use disorderFMRI scanningNeural predictorsStudy 1Study 2Treatment outcomesContingency managementPrior workComparison subjectsNetwork strengthUse disordersNovel treatment targetsAbstinenceIndependent samplesCocaine abstinenceTreatment responders
2021
A pilot economic evaluation of computerized cognitive behavioral therapy for alcohol use disorder as an addition and alternative to traditional therapy
Kacmarek CN, Yates BT, Nich C, Kiluk BD. A pilot economic evaluation of computerized cognitive behavioral therapy for alcohol use disorder as an addition and alternative to traditional therapy. Alcohol Clinical And Experimental Research 2021, 45: 1109-1121. PMID: 33730384, PMCID: PMC8131237, DOI: 10.1111/acer.14601.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismAmbulatory CareCognitive Behavioral TherapyCost-Benefit AnalysisFemaleHealth ServicesHumansMaleMiddle AgedPilot ProjectsTherapy, Computer-AssistedTreatment OutcomeConceptsAlcohol use disorderIncremental cost-effective ratioCognitive behavioral therapyStandard outpatient treatmentPilot economic evaluationOutpatient treatmentTreatment costsUse disordersDrinking daysBehavioral therapyComputerized cognitive behavioral therapyEvidence-based treatmentsOutpatient treatment facilitiesTotal treatment costsCost of treatmentCost-effective ratioComputer-delivered interventionNet benefit analysisHealthcare utilizationCost-effective additionClinical trialsTreatment protocolCriminal justice involvementTraditional therapiesTreatment terminationCognitive-Behavioral Interventions Targeting Alcohol or Other Drug Use and Co-Occurring Mental Health Disorders: A Meta-Analysis
Mehta K, Hoadley A, Ray LA, Kiluk BD, Carroll KM, Magill M. Cognitive-Behavioral Interventions Targeting Alcohol or Other Drug Use and Co-Occurring Mental Health Disorders: A Meta-Analysis. Alcohol And Alcoholism 2021, 56: 535-544. PMID: 33778869, PMCID: PMC8406071, DOI: 10.1093/alcalc/agab016.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedCognitive Behavioral TherapyFemaleHumansMaleMental DisordersMiddle AgedRandomized Controlled Trials as TopicSubstance-Related DisordersYoung AdultConceptsCognitive-behavioral interventionsMental health disordersCo-occurring mental health disordersHealth disordersDrug useEffect sizeDrug use disordersSignificant residual heterogeneityHigh-quality studiesMental health symptomsPost-traumatic stress disorderUnderstanding of treatmentMeta-regression modelsClinical trialsStudy qualityPromising effect sizesUse disordersStudy heterogeneityMHD diagnosisHealth symptomsMeta-AnalysisStress disorderAlcohol useTime pointsSmall effect sizes
2020
Evaluating a Longitudinal Mediation Model of Perceived Stress, Depressive Symptoms, and Substance Use Treatment Outcomes
Roos CR, Kiluk BD, McHugh RK, Carroll KM. Evaluating a Longitudinal Mediation Model of Perceived Stress, Depressive Symptoms, and Substance Use Treatment Outcomes. Psychology Of Addictive Behaviors 2020, 34: 660-668. PMID: 32297754, PMCID: PMC7483283, DOI: 10.1037/adb0000581.Peer-Reviewed Original ResearchConceptsIllicit opioid useOpioid useDepressive symptomsUse disordersSubstance use outcomesMethadone treatmentStandard methadone treatmentTrial of galantamineUse outcomesOpioid use disorderSubstance Use Treatment OutcomesSubstance use disordersCocaine use disorderCognitive behavioral therapyLongitudinal treatment studyTreatment outcomesPredictors of endPosttreatment outcomesSymptomsTreatment studiesSignificant total effectSubstance useBaselineOutcomesDisordersCombined Pharmacotherapy and Cognitive Behavioral Therapy for Adults With Alcohol or Substance Use Disorders
Ray LA, Meredith LR, Kiluk BD, Walthers J, Carroll KM, Magill M. Combined Pharmacotherapy and Cognitive Behavioral Therapy for Adults With Alcohol or Substance Use Disorders. JAMA Network Open 2020, 3: e208279. PMID: 32558914, PMCID: PMC7305524, DOI: 10.1001/jamanetworkopen.2020.8279.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive Behavioral TherapyDrug Therapy, CombinationFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicSubstance-Related DisordersTreatment OutcomeConceptsSubstance use disordersAdult alcohol use disordersCognitive behavioral therapyUsual careRandomized clinical trialsUse disordersBehavioral therapySpecific therapyClinical trialsAddition of CBTSuperiority of CBTTreatment of SUDsUsual clinical managementForms of pharmacotherapyFirst-line interventionEvidence-based therapiesClinical trial samplesEvidence-based modalitiesAlcohol use disorderEnglish-language articlesPublic health concernFull-text articlesEffect sizeCochrane RegisterRandom effects estimatesThe search for mechanisms of cognitive behavioral therapy for alcohol or other drug use disorders: A systematic review
Magill M, Tonigan JS, Kiluk B, Ray L, Walthers J, Carroll K. The search for mechanisms of cognitive behavioral therapy for alcohol or other drug use disorders: A systematic review. Behaviour Research And Therapy 2020, 131: 103648. PMID: 32474226, PMCID: PMC7329023, DOI: 10.1016/j.brat.2020.103648.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyDrug use disordersUse disordersSystematic reviewBehavioral therapyRandomized clinical trialsStudy inclusion criteriaPatient behavior changeCBT-based treatmentClinical trialsInclusion criteriaStatistical mediatorMediator candidatesIntervention ingredientsProject MATCHCBT mechanismsTherapyBehavior change frameworkMediatorsBehavior changeDisordersAddiction researchReportReviewReview sampleShort- and long-term changes in substance-related coping as mediators of in-person and computerized CBT for alcohol and drug use disorders
Roos CR, Carroll KM, Nich C, Frankforter T, Kiluk BD. Short- and long-term changes in substance-related coping as mediators of in-person and computerized CBT for alcohol and drug use disorders. Drug And Alcohol Dependence 2020, 212: 108044. PMID: 32422538, PMCID: PMC7293942, DOI: 10.1016/j.drugalcdep.2020.108044.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultCognitive Behavioral TherapyFemaleHumansMaleMiddle AgedSubstance-Related DisordersTherapy, Computer-AssistedTime FactorsTreatment OutcomeConceptsCognitive behavioral therapyComputerized cognitive behavioral therapyPerson cognitive-behavioural therapySubstance use disordersMediation effectAlcohol use disorderComputer-delivered cognitive behavioural therapyUse disordersSame mediation effectSubstance-related copingCoping Strategies ScaleSignificant mediation effectMechanisms of changeMediational modelCoping skillsStrategies ScaleCBT4CBTStatistical mediatorCopingDrug use disordersSubstance useHeavy drinkingDisordersLong-term changesLong-term increaseInitial testing of a computer-based simulation training module to support clinicians' acquisition of CBT skills for substance use disorder treatment
Mastroleo NR, Humm L, Williams CM, Kiluk BD, Hoadley A, Magill M. Initial testing of a computer-based simulation training module to support clinicians' acquisition of CBT skills for substance use disorder treatment. Journal Of Substance Use And Addiction Treatment 2020, 114: 108014. PMID: 32527511, PMCID: PMC7361509, DOI: 10.1016/j.jsat.2020.108014.Peer-Reviewed Original ResearchMeSH KeywordsCognitive Behavioral TherapyComputersHumansMotivational InterviewingSimulation TrainingSubstance-Related Disorders
2019
Changes in DSM criteria following a culturally-adapted computerized CBT for Spanish-speaking individuals with substance use disorders
Silva MA, Jaramillo Y, Paris M, Añez-Nava L, Frankforter TL, Kiluk BD. Changes in DSM criteria following a culturally-adapted computerized CBT for Spanish-speaking individuals with substance use disorders. Journal Of Substance Use And Addiction Treatment 2019, 110: 42-48. PMID: 31952627, PMCID: PMC6981257, DOI: 10.1016/j.jsat.2019.12.006.Peer-Reviewed Original ResearchMeSH KeywordsCognitive Behavioral TherapyDiagnostic and Statistical Manual of Mental DisordersHumansSubstance-Related DisordersTherapy, Computer-AssistedTreatment OutcomeConceptsSubstance use disordersAddiction Severity IndexUse disordersDSM criteriaStructured Clinical InterviewDSM-IV substance dependenceMeaningful outcomesDiagnostic statusTimeline followback methodStatistical Manual criteriaCognitive behavioral therapy programBehavioral therapy programSubstance use outcomesProblem severityDSM-IV dependence criteriaPrimary outcomeUrine toxicologyLower problem severityClinical trialsTreatment periodMain trialOutpatient counselingClinical InterviewSecondary analysisDSM-IVA Meta-Analysis of Cognitive-Behavioral Therapy for Alcohol or Other Drug Use Disorders: Treatment Efficacy by Contrast Condition
Magill M, Ray L, Kiluk B, Hoadley A, Bernstein M, Tonigan JS, Carroll K. A Meta-Analysis of Cognitive-Behavioral Therapy for Alcohol or Other Drug Use Disorders: Treatment Efficacy by Contrast Condition. Journal Of Consulting And Clinical Psychology 2019, 87: 1093-1105. PMID: 31599606, PMCID: PMC6856400, DOI: 10.1037/ccp0000447.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismCognitive Behavioral TherapyHumansOutcome Assessment, Health CareSubstance-Related DisordersConceptsCognitive behavioral therapyDrug use disordersUse disordersEffect sizeConsumption frequencyTime pointsEvidence-based therapiesPooled effect sizeMinimal treatmentEstimates of efficacyTest of heterogeneityCBT effectsNonspecific therapySpecific therapySuperior efficacyStudy-level moderatorsModerate heterogeneityTreatment efficacySignificant effect sizeMultivariate analysisMeta-AnalysisTherapyPublication biasStudy aimNonspecific controlTechnology‐Delivered Cognitive‐Behavioral Interventions for Alcohol Use: A Meta‐Analysis
Kiluk BD, Ray LA, Walthers J, Bernstein M, Tonigan JS, Magill M. Technology‐Delivered Cognitive‐Behavioral Interventions for Alcohol Use: A Meta‐Analysis. Alcohol Clinical And Experimental Research 2019, 43: 2285-2295. PMID: 31566787, PMCID: PMC6824956, DOI: 10.1111/acer.14189.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyAlcohol usePerson cognitive-behavioural therapyEffect sizePooled effect sizeDelivery of CBTEvidence-based interventionsStand-alone treatmentMinimal treatment controlUsual careCognitive-behavioral interventionsSuperior efficacyClinical practiceTechnology-based deliveryHeavy drinkersMeta-AnalysisPsychiatric conditionsWeb-based programHeavy drinkingMotivational interviewingEfficacyTreatment controlInterventionWeighted effect sizeTherapy
2018
Culturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial.
Paris M, Silva M, Añez-Nava L, Jaramillo Y, Kiluk BD, Gordon MA, Nich C, Frankforter T, Devore K, Ball SA, Carroll KM. Culturally Adapted, Web-Based Cognitive Behavioral Therapy for Spanish-Speaking Individuals With Substance Use Disorders: A Randomized Clinical Trial. American Journal Of Public Health 2018, 108: 1535-1542. PMID: 30252519, PMCID: PMC6187780, DOI: 10.2105/ajph.2018.304571.Peer-Reviewed Original ResearchMeSH KeywordsAdultCognitive Behavioral TherapyConnecticutCulturally Competent CareFemaleHispanic or LatinoHumansInternetMaleSubstance-Related DisordersTreatment OutcomeConceptsSubstance use disordersCognitive-behavioral treatmentUse disordersSubstance use outcomesClinical trialsWeb-based cognitive behavioral therapyCurrent substance use disorderUse outcomesRandomized clinical trialsStandard outpatient treatmentEvidence-based treatmentsCognitive behavioral therapyPrimary outcomeStandard treatmentOutpatient treatmentStandard outpatientTreatment completionHealth disparitiesBehavioral therapyBehavioral treatmentAddiction treatmentTreatment-seeking individualsGreater reductionTreatmentDisordersCommentary on Litt et al. (2018): Identifying treatment‐targeted mechanisms—aim and measure the bullseye
Kiluk BD. Commentary on Litt et al. (2018): Identifying treatment‐targeted mechanisms—aim and measure the bullseye. Addiction 2018, 113: 1418-1419. PMID: 29998621, PMCID: PMC6151125, DOI: 10.1111/add.14258.Peer-Reviewed Original ResearchRandomized Clinical Trial of Computerized and Clinician-Delivered CBT in Comparison With Standard Outpatient Treatment for Substance Use Disorders: Primary Within-Treatment and Follow-Up Outcomes
Kiluk BD, Nich C, Buck MB, Devore KA, Frankforter TL, LaPaglia DM, Muvvala SB, Carroll KM. Randomized Clinical Trial of Computerized and Clinician-Delivered CBT in Comparison With Standard Outpatient Treatment for Substance Use Disorders: Primary Within-Treatment and Follow-Up Outcomes. American Journal Of Psychiatry 2018, 175: 853-863. PMID: 29792052, PMCID: PMC6120780, DOI: 10.1176/appi.ajp.2018.17090978.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmbulatory CareCognitive Behavioral TherapyFemaleFollow-Up StudiesHumansMaleSubstance-Related DisordersTherapy, Computer-AssistedTreatment OutcomeConceptsCognitive behavioral therapySubstance use disordersComputer-based cognitive behavioral therapyUse disordersMinimal clinical monitoringTreatment-seeking populationTreatment-seeking outpatientsDSM-IV-TR criteriaCBT groupFrequency of substanceStandard outpatient careCBT4CBTStand-alone treatmentDiverse sampleStandard outpatient treatmentCurrent substance use disorderBehavioral conceptsBetter learningSubstance abuseHeterogeneous sampleUp OutcomesHigh dropout ratePrevious trialsSix-month followClinical trials
2017
Drug Stroop: Mechanisms of response to computerized cognitive behavioral therapy for cocaine dependence in a randomized clinical trial
DeVito EE, Kiluk BD, Nich C, Mouratidis M, Carroll KM. Drug Stroop: Mechanisms of response to computerized cognitive behavioral therapy for cocaine dependence in a randomized clinical trial. Drug And Alcohol Dependence 2017, 183: 162-168. PMID: 29258028, PMCID: PMC5803332, DOI: 10.1016/j.drugalcdep.2017.10.022.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultCocaine-Related DisordersCognitive Behavioral TherapyCuesExecutive FunctionFemaleHumansMaleReaction TimeStroop TestTherapy, Computer-AssistedTreatment OutcomeConceptsCognitive behavioral therapyDrug-related stimuliAttentional biasDrug-related cuesCognitive controlStroop effectStroop taskBehavioral therapyTreatment componentsComputer-based cognitive behavioral therapyComputerized cognitive behavioral therapyPoor cognitive controlCognitive control processesExecutive cognitive controlSubstance use severityCocaine use outcomesCocaine use disorderResponse inhibitionUse severityUse outcomesControl processGreater engagementTreatment retentionCBT4CBTCocaine dependenceCognitive Behavioral Interventions for Alcohol and Drug Use Disorders: Through the Stage Model and Back Again
Carroll KM, Kiluk BD. Cognitive Behavioral Interventions for Alcohol and Drug Use Disorders: Through the Stage Model and Back Again. Psychology Of Addictive Behaviors 2017, 31: 847-861. PMID: 28857574, PMCID: PMC5714654, DOI: 10.1037/adb0000311.Peer-Reviewed Original ResearchConceptsCognitive-behavioral therapy approachStage modelAlcohol use disorderCognitive scienceCBT interventionLarge evidence baseModest effect sizesAddictive disordersCore featuresCBTEmpirical supportMental healthImplementation cliffPowerful interventionUse disordersNovel settingStatic interventionsEffect sizeTreatment of drugAddictionTherapy approachesDurable effectsInterventionEvidence basePsychologyEffect of computerized cognitive behavioral therapy on acquisition of coping skills among cocaine-dependent individuals enrolled in methadone maintenance
Kiluk BD, DeVito EE, Buck MB, Hunkele K, Nich C, Carroll KM. Effect of computerized cognitive behavioral therapy on acquisition of coping skills among cocaine-dependent individuals enrolled in methadone maintenance. Journal Of Substance Use And Addiction Treatment 2017, 82: 87-92. PMID: 29021121, PMCID: PMC5687291, DOI: 10.1016/j.jsat.2017.09.011.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultCocaine-Related DisordersCognitive Behavioral TherapyFemaleHumansMaleMethadoneTherapy, Computer-AssistedConceptsCognitive behavioral therapyCocaine-dependent individualsHigh-risk situationsBehavioral therapyVerbal responsesComputerized cognitive behavioral therapyAbstinence outcomesComputerized CBT programParticipants' verbal responsesRole-play assessmentComputer-based trainingCertain high-risk situationsStandard methadone treatmentSubstance use disordersConsistent statistical supportCBT programMethadone treatmentMethadone maintenanceDependent individualsPlay assessmentPrior findingsClinical trialsTreatment periodUse disordersSubstance users
2016
Just Showing Up Is Not Enough: Homework Adherence and Outcome in Cognitive–Behavioral Therapy for Cocaine Dependence
Decker SE, Kiluk BD, Frankforter T, Babuscio T, Nich C, Carroll KM. Just Showing Up Is Not Enough: Homework Adherence and Outcome in Cognitive–Behavioral Therapy for Cocaine Dependence. Journal Of Consulting And Clinical Psychology 2016, 84: 907-912. PMID: 27454780, PMCID: PMC5341374, DOI: 10.1037/ccp0000126.Peer-Reviewed Original ResearchConceptsUrine toxicology screenCognitive behavioral therapyCocaine use outcomesHomework adherenceTreatment attendanceToxicology screenCocaine useUse outcomesMultiple logistic regressionBaseline cocaine useVariety of disordersCocaine use severityTreatment endClinical trialsCocaine use frequencyImproved outcomesCocaine dependenceLogistic regressionCBT sessionsAdherenceUse severityPrior studiesGreater reductionOutcomesTreatmentRandomized Trial of Computerized Cognitive Behavioral Therapy for Alcohol Use Disorders: Efficacy as a Virtual Stand‐Alone and Treatment Add‐On Compared with Standard Outpatient Treatment
Kiluk BD, Devore KA, Buck MB, Nich C, Frankforter TL, LaPaglia DM, Yates BT, Gordon MA, Carroll KM. Randomized Trial of Computerized Cognitive Behavioral Therapy for Alcohol Use Disorders: Efficacy as a Virtual Stand‐Alone and Treatment Add‐On Compared with Standard Outpatient Treatment. Alcohol Clinical And Experimental Research 2016, 40: 1991-2000. PMID: 27488212, PMCID: PMC5008977, DOI: 10.1111/acer.13162.Peer-Reviewed Original ResearchConceptsAlcohol use disorderCognitive behavioral therapyComputerized cognitive behavioral therapyAlcohol useUse disordersClinical monitoringBehavioral therapyCurrent alcohol use disorderStandard outpatient treatmentEvidence-based treatmentsWeb-based CBT programPercentage of daysRandomized trialsPreliminary efficacyStandard treatmentOutpatient treatmentTreatment completionTreatment periodOutpatient facilitiesParticipants' alcohol useClinical practiceCBT4CBTCBT programTreatment-seeking individualsClinical samples