2024
Examining cocaine use reductions and long-term outcomes in two clinical trials of continuing care for cocaine dependence
Votaw V, Tuchman F, Roos C, Hebden H, McKay J, Kiluk B, Witkiewitz K. Examining cocaine use reductions and long-term outcomes in two clinical trials of continuing care for cocaine dependence. Journal Of Substance Use And Addiction Treatment 2024, 163: 209394. PMID: 38735481, PMCID: PMC11180556, DOI: 10.1016/j.josat.2024.209394.Peer-Reviewed Original ResearchCocaine use disorderCocaine useAssociated with less cocaine useTelephone-based continuing careLevel of cocaine useFollow-upDrug use consequencesAssociated with lower levelsClinical trialsBaseline to 12-month follow-upCocaine dependenceTreatment entryProblem severityUse disorderTimeline FollowbackCocaineInitial treatment phaseAbstinenceLow-frequency useLong-term functional outcomeEffect sizeTreatment phaseLong-term outcomesRandomized clinical trialsNegative consequencesPatient perspectives on current and potential therapies and clinical trial approaches for cocaine use disorder
Maahs S, Leclair D, Gomez-Mancilla B, Kiluk B, Muthusamy V, Banerjee P, Dasgupta S, Waye K. Patient perspectives on current and potential therapies and clinical trial approaches for cocaine use disorder. Frontiers In Psychiatry 2024, 15: 1230699. PMID: 38487570, PMCID: PMC10937549, DOI: 10.3389/fpsyt.2024.1230699.Peer-Reviewed Original ResearchCocaine use disorderLong-term abstinenceSubstance use disordersBarriers to therapyWithdrawal symptomsUse disorderCraving controlClinical trialsCocaineClinical trial approachesDesign of clinical trialsCravingScreening questionnaireDisordersClinical trial outcomesTrial outcomesPerspectives of individualsRemissionParticipantsDrug seekersPotential therapiesTherapyIndividualsRecruited participantsAbstinence
2023
Distinct neural networks predict cocaine versus cannabis treatment outcomes
Lichenstein S, Kohler R, Ye F, Potenza M, Kiluk B, Yip S. Distinct neural networks predict cocaine versus cannabis treatment outcomes. Molecular Psychiatry 2023, 28: 3365-3372. PMID: 37308679, PMCID: PMC10713861, DOI: 10.1038/s41380-023-02120-0.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingCognitive behavior therapyCognitive behavioral therapySubstance use disordersCannabis abstinenceNeural mechanismsBehavior therapyDistinct neural networksComputer-based trainingCannabis use disorderFMRI scanningNeural predictorsStudy 1Study 2Treatment outcomesContingency managementPrior workComparison subjectsNetwork strengthUse disordersNovel treatment targetsAbstinenceIndependent samplesCocaine abstinenceTreatment respondersPercentage of negative urine drug screens as a clinically meaningful endpoint for RCTs evaluating treatment for cocaine use
Loya J, Babuscio T, Nich C, Alessi S, Rash C, Kiluk B. Percentage of negative urine drug screens as a clinically meaningful endpoint for RCTs evaluating treatment for cocaine use. Drug And Alcohol Dependence 2023, 248: 109947. PMID: 37276806, PMCID: PMC10498479, DOI: 10.1016/j.drugalcdep.2023.109947.Peer-Reviewed Original ResearchConceptsUrine drug screensClinical trialsMeaningful endpointsCocaine useLong-term clinical benefitBetter long-term outcomesDrug screensPsychosocial functioningNegative urine drug screensLong-term outcomesRandomized clinical trialsFuture clinical trialsBetter psychosocial functioningClinical benefitPharmacological treatmentContinuous abstinenceTreatment periodTreatment respondersSustained abstinenceSubstance useTrialsTreatmentMeaningful thresholdPooled datasetAbstinence
2018
What defines a clinically meaningful outcome in the treatment of substance use disorders: reductions in direct consequences of drug use or improvement in overall functioning?
Kiluk BD, Fitzmaurice GM, Strain EC, Weiss RD. What defines a clinically meaningful outcome in the treatment of substance use disorders: reductions in direct consequences of drug use or improvement in overall functioning? Addiction 2018, 114: 9-15. PMID: 29900624, PMCID: PMC6289694, DOI: 10.1111/add.14289.Peer-Reviewed Original ResearchConceptsSubstance use disordersDrug useUse disordersMost substance use disordersTreatment Efficacy TrialMeaningful outcomesOverall functioningException of alcoholAlcohol-related consequencesAspects of functioningPharmacotherapy trialsEfficacy trialsHealth consequencesIndividual functioningTrialsLong-term functioningWeak associationDisordersCurrent standardFunctioningUse trialOutcomesAssociationAbstinence
2015
Outcome expectations and associated treatment outcomes in motivational enhancement therapy delivered in English and Spanish
Serafini K, Decker S, Kiluk BD, Añez L, Paris M, Frankforter T, Carroll KM. Outcome expectations and associated treatment outcomes in motivational enhancement therapy delivered in English and Spanish. American Journal On Addictions 2015, 24: 732-739. PMID: 26541501, PMCID: PMC4885684, DOI: 10.1111/ajad.12301.Peer-Reviewed Original ResearchConceptsPatients' outcome expectationsTreatment outcomesMotivational enhancement therapyEnhancement therapyUrine toxicology screenLikelihood of abstinenceSubstance use disordersSubstance use outcomesToxicology screenClinical trialsTreatment periodUse disordersOutcome expectationsSecondary analysisSubstance useAbstinenceUse outcomesOutcomesMetSTherapyTreatmentBaseline expectationsGreater percentageSame treatmentImportant predictor