Sasha Zivkovic, MD, PhD
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Clinical Director, Yale CMTA Center of Excellence (adults), Charcot Marie Tooth Disease (CMT) Program
Academic Chief, Neuromuscular Medicine, Neurology
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Clinical Director, Yale CMTA Center of Excellence (adults), Charcot Marie Tooth Disease (CMT) Program
Academic Chief, Neuromuscular Medicine, Neurology
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Are You a Patient?
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View Doctor ProfileAdditional Titles
Clinical Director, Yale CMTA Center of Excellence (adults), Charcot Marie Tooth Disease (CMT) Program
Academic Chief, Neuromuscular Medicine, Neurology
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About
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Titles
Professor
Clinical Director, Yale CMTA Center of Excellence (adults), Charcot Marie Tooth Disease (CMT) Program; Academic Chief, Neuromuscular Medicine, Neurology
Appointments
Neurology
ProfessorPrimary
Other Departments & Organizations
- Cardiac Amyloidosis Program
- Charcot Marie Tooth Disease (CMT) Program
- Neurology
- Neuromuscular Medicine
- Yale Medicine
- Yale New Haven Health System
Education & Training
- PhD
- University of Zagreb (2009)
- MSc
- University of Zagreb, Biomedicine
- MD
- University of Zagreb (1992)
Research
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Overview
Medical Research Interests
Research at a Glance
Publications Timeline
Research Interests
Amyloid Neuropathies, Familial
Guillain-Barre Syndrome
Polyneuropathies
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Publications
2024
Diagnosing X-Linked Myopathy With Excessive Autophagy After 30 years: Genetic, Ultrasonographic, and Electrodiagnostic Findings
Dwairi V, Giacobbe A, Zivkovic S, Lacomis D. Diagnosing X-Linked Myopathy With Excessive Autophagy After 30 years: Genetic, Ultrasonographic, and Electrodiagnostic Findings. Journal Of Clinical Neuromuscular Disease 2024, 26: 12-15. PMID: 39163157, DOI: 10.1097/cnd.0000000000000500.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsGenetic testingNeuromuscular ultrasoundX-linked myopathyProximal weaknessMuscle histopathological findingsLoss of ambulationProgressive proximal weaknessCapillary endothelial cellsEDX findingsFactor genesExtensive workupElectrodiagnostic findingsMuscle biopsyHistopathological findingsExcessive autophagyAutophagic vacuolar myopathyMyotonic dischargesTeenage yearsEndothelial cellsX-linkedDisease severityMyopathyVacuolar myopathyMuscleAutophagyLate Onset of Severe Demyelinating Peripheral Neuropathy in a 62-Year-Old African American Woman
Zivkovic S, DiCapua D. Late Onset of Severe Demyelinating Peripheral Neuropathy in a 62-Year-Old African American Woman. Journal Of Clinical Neuromuscular Disease 2024, 25: 152-156. PMID: 38441936, DOI: 10.1097/cnd.0000000000000481.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsAfrican American womenAmerican womenSevere carpal tunnel syndromeCarpal tunnel syndromeHistory of gaitSensorimotor demyelinating polyneuropathyDemyelinating sensorimotor polyneuropathyEarly onset of symptomsSevere demyelinating peripheral neuropathyWalking difficultiesOnset of symptomsFamily historyNatural history studiesCharcot-Marie-Tooth diseaseGenetic testingTunnel syndromeHomozygous pathogenic mutationDistal sensory lossExamination scoresCharcot-Marie-ToothElectrodiagnostic testingDemyelinating polyneuropathySensorimotor polyneuropathySH3TC2 geneUnwitnessed fallNeuromuscular manifestations of wild type transthyretin amyloidosis: a review and single center’s experience
Živković S, Lacomis D, Soman P. Neuromuscular manifestations of wild type transthyretin amyloidosis: a review and single center’s experience. Frontiers In Cardiovascular Medicine 2024, 11: 1345608. PMID: 38410247, PMCID: PMC10894993, DOI: 10.3389/fcvm.2024.1345608.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricConceptsATTRwt patientsPeripheral neuropathyPrevalence of peripheral neuropathySuspected peripheral neuropathyCases of neuropathyDistal sensory lossTransthyretin amyloid depositionCardiomyopathy patientsClinical featuresTransthyretin genotypingMusculoskeletal manifestationsNeuropathy symptomsATTRwtTransthyretin amyloidosisElderly patientsHeart failureTransthyretin mutationFrequent comorbiditiesMultiple potential causesNeuropathySensory lossElderly menPatientsSenile amyloidosisPeripheral nerves
2023
Patients with transthyretin amyloidosis enrolled in THAOS between 2018 and 2021 continue to experience substantial diagnostic delay
Coelho T, Dispenzieri A, Grogan M, Conceição I, Waddington-Cruz M, Kristen A, Wixner J, Diemberger I, Gonzalez-Moreno J, Maurer M, Planté-Bordeneuve V, Garcia-Pavia P, Tournev I, Gonzalez-Costello J, Cariou E, González-Duarte A, Glass O, Chapman D, Amass L, Hüsing-Kabar A, Drachman B, Adrian Barroso F, Ueda M, Sekijima Y, Mazzeo A, Gentile L, Jeon E, Slosky D, Luigetti M, Hanna M, Freimer M, Muñoz-Beamud F, Adams D, Mølgaard H, Press R, Nienhuis H, Cirami C, Emdin M, Miller E, Campistol Plana J, Inamo J, Quan D, Hummel S, Dori A, Witteles R, Shah S, Lenihan D, Azevedo O, Tan C, Murali S, Zivkovic S, Correia E, Nicolau J, Tallaj J, Fine N, Tschöpe C, Torrón R, Polydefkis M, Obici L, Badelita S, Gottlieb S, Tauras J, Ventura H, Brunkhorst R, Darstein F, Oh J, Marburger T, Mueller C, Cleemput J, Salutto V, Parman Y, Chao C, Sarswat N, Warner A, Steidley D, Ralph J, Cotts W, Hoffman J, Rugiero M, Misawa S, Muñoz-Blanco J, Davila L, Sadeh M, Luo J, Kyriakides T, Wang A, Kaufmann H. Patients with transthyretin amyloidosis enrolled in THAOS between 2018 and 2021 continue to experience substantial diagnostic delay. Amyloid 2023, 30: 445-448. PMID: 37459334, DOI: 10.1080/13506129.2023.2229484.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsChapter 10 Muscular dystrophy ∗
Puwanant A, Živković S, Clemens P. Chapter 10 Muscular dystrophy ∗. 2023, 147-164. DOI: 10.1016/b978-0-323-85654-6.00055-1.ChaptersCitationsConceptsMuscular dystrophyStudies of gene therapyProgressive disorderDuchenne muscular dystrophyDisorders of muscleMyotonic dystrophy type 1Gene therapyInitial symptomsHereditary disorderPharmacological treatmentMuscle weaknessDestruction of muscleFacioscapulohumeral dystrophyDiagnostic abilityEffective treatmentType 1DystrophyMuscle functionHeterogeneous groupEarly onsetMaintenance of muscle functionMuscle fibersFibrous tissueMuscleMuscle development
2022
A Second Case of Treatment-resistant CIDP in an IgG Tubulin Autoantibody Positive Patient
Giacobbe A, Al-Lahham T, Ojha A, Zivkovic S. A Second Case of Treatment-resistant CIDP in an IgG Tubulin Autoantibody Positive Patient. RRNMF Neuromuscular Journal 2022, 3: 21-24. DOI: 10.17161/rrnmf.v3i3.17691.Peer-Reviewed Original ResearchSex Differences in Wild-Type Transthyretin Amyloidosis: An Analysis from the Transthyretin Amyloidosis Outcomes Survey (THAOS).
Campbell CM, LoRusso S, Dispenzieri A, Kristen AV, Maurer MS, Rapezzi C, Lairez O, Drachman B, Garcia-Pavia P, Grogan M, Chapman D, Amass L, THAOS investigators.. Sex Differences in Wild-Type Transthyretin Amyloidosis: An Analysis from the Transthyretin Amyloidosis Outcomes Survey (THAOS). Cardiol Ther 2022 PMID: 35583798, DOI: 10.1007/s40119-022-00265-7.Peer-Reviewed Original ResearchInternational Validation of the Erasmus Guillain-Barré Syndrome Respiratory Insufficiency Score.
Doets AY, Walgaard C, Lingsma HF, Islam B, Papri N, Yamagishi Y, Kusunoki S, Dimachkie MM, Waheed W, Kolb N, Gorson KC, Jacobs BC, IGOS Consortium.. International Validation of the Erasmus Guillain-Barré Syndrome Respiratory Insufficiency Score. Ann Neurol 2022, 91: 521-531. PMID: 35106830, DOI: 10.1002/ana.26312.Peer-Reviewed Original ResearchA Case of Probable Multifocal Motor Neuropathy With Clinical Stability for Ten Years After a Single Treatment of Rituximab
Gonzalez N, Juel V, Živković S. A Case of Probable Multifocal Motor Neuropathy With Clinical Stability for Ten Years After a Single Treatment of Rituximab. Journal Of Clinical Neuromuscular Disease 2022, 23: 136-142. PMID: 35188910, DOI: 10.1097/cnd.0000000000000358.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMultifocal motor neuropathyMotor neuropathyIntravenous immunoglobulinImmune-mediated motor neuropathyResponse to intravenous immunoglobulinEfficacy of intravenous immunoglobulinNo significant progressSignificant progression of diseaseTreatment of rituximabSecond-line agentsSingle treatmentProgression of diseaseClinical stabilityCase reportRituximabTherapeutic efficacyUncontrolled studiesProgressive weaknessSymptom onsetNeuropathyImmunoglobulinEfficacyPredicting Outcome in Guillain-Barré Syndrome: International Validation of the Modified Erasmus GBS Outcome Score.
Doets AY, Lingsma HF, Walgaard C, Islam B, Papri N, Davidson A, Yamagishi Y, Kusunoki S, Dimachkie MM, Waheed W, Kolb N, Islam Z, Mohammad QD, Harbo T, Sindrup SH, Chavada G, Willison HJ, Casasnovas C, Bateman K, Miller JAL, van den Berg B, Verboon C, Roodbol J, Leonhard SE, Benedetti L, Kuwabara S, Van den Bergh P, Monges S, Marfia GA, Shahrizaila N, Galassi G, Péréon Y, Bürmann J, Kuitwaard K, Kleyweg RP, Marchesoni C, Sedano Tous MJ, Querol L, Illa I, Wang Y, Nobile-Orazio E, Rinaldi S, Schenone A, Pardo J, Vermeij FH, Lehmann HC, Granit V, Cavaletti G, Gutiérrez-Gutiérrez G, Barroso FA, Visser LH, Katzberg HD, Dardiotis E, Attarian S, van der Kooi AJ, Eftimov F, Wirtz PW, Samijn JPA, Gilhuis HJ, Hadden RDM, Holt JKL, Sheikh KA, Karafiath S, Vytopil M, Antonini G, Feasby TE, Faber CG, Gijsbers CJ, Busby M, Roberts RC, Silvestri NJ, Fazio R, van Dijk GW, Garssen MPJ, Straathof CSM, Gorson KC, Jacobs BC, IGOS Consortium.. Predicting Outcome in Guillain-Barré Syndrome: International Validation of the Modified Erasmus GBS Outcome Score. Neurology 2022, 98: e518-e532. PMID: 34937789, DOI: 10.1212/WNL.0000000000013139.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
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Activities
activity Journal of Clinical Neuromuscular Disease
10/01/2021 - PresentJournal ServiceEditorial Board Memberactivity “Immunization, Infections and Neuromuscular Disorders"
10/14/2021 - PresentLecture“Immunization, Infections and Neuromuscular Disorders" (Infections and Immunizations in NMD; Director Pushpa Narayanaswami, M.D.), Annual Meeting of AANEMDetailsDenver, CO, United StatesSponsored by AANEMAbstract/Synopsis“Immunization, Infections and Neuromuscular Disorders (Infections and Immunizations in NMD; Director Pushpa Narayanaswami, M.D.). Annual Meeting of American Association of Neuromuscular & Electrodiagnostic Medicine, Denver, CO, 2021 Oct 13
activity Neurologic complications of immune checkpoint inhibitors
10/14/2019 - PresentLecture"Neurologic complications of immune checkpoint inhibitors", SIG Neuro-Oncology meeting (Chairs: Santosh Kesari, MD, Jan Drappatz, MD) at 144th Annual Meeting of ANA, St Louis, MODetailsSt. Louis, MO, United StatesSponsored by 144th Annual meeting of ANAAbstract/SynopsisPresented at SIG Neuro-Oncology meeting (Chairs: Santosh Kesari, MD, Jan Drappatz, MD) at 144th Annual Meeting of ANA, St Louis, MO
activity "Guillain Barre syndrome 2016: first hundred years"
05/25/2016 - PresentLecture"Guillain Barre syndrome 2016: first hundred years" Cleveland Clinic Akron General Medical Center Neurology Grand RoundsDetailsAkron, OH, United StatesSponsored by Cleveland Clinic Akron General Medical Centeractivity Neuropathy and monoclonal gammopathy
02/18/2016 - PresentLecture"Neuropathy and monoclonal gammopathy", UCHC Department of Neurology Grand RoundsDetailsHartford, CT, United StatesSponsored by University of Connecticut
Honors
honor Fellow
10/01/2018Other AwardAmerican Academy of NeurologyDetailsUnited States
Clinical Care
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Overview
Sasha Zivkovic, MD, PhD, is a neurologist with a focus on diagnosing and treating a range of neuromuscular disorders.
These include including hereditary sensory and motor neuropathies (genetic disorders affecting peripheral nerves, leading to sensory loss and muscle weakness), amyloid neuropathies (where abnormal protein deposits, called amyloids, accumulate in nerves), Guillain-Barré Syndrome (an acute autoimmune disorder where the body's immune system attacks the peripheral nerves, causing weakness and paralysis), and POEMS Syndrome (a rare blood disorder causing nerve damage, enlarged organs, hormone issues, abnormal blood cells, and skin changes).
As a professor of neurology at Yale School of Medicine, Dr. Zivkovic serves as the academic chief of neuromuscular medicine and is the clinical director of the Yale CMTA (Charcot Marie Tooth Association) Center of Excellence for adults. His work aims to advance the understanding and management of complex neuromuscular conditions, particularly those with genetic or immunological components.
Dr. Zivkovic received his medical and doctoral degrees from the University of Zagreb in Croatia.
Clinical Specialties
Fact Sheets
Amyloidosis
Learn More on Yale MedicineNeuropathy
Learn More on Yale MedicinePeripheral Neuropathy
Learn More on Yale MedicineCardiac Amyloidosis
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Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.