Sabrina Browning, MD
Assistant Professor of Medicine (Hematology)Cards
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About
Titles
Assistant Professor of Medicine (Hematology)
Biography
Dr. Sabrina Browning received her medical degree from the University of Connecticut School of Medicine where she first confirmed her passion for caring for individuals with hematologic diseases. Her internship and residency were completed at Yale New Haven Hospital. After residency, Dr. Browning served as Amyloid Fellow at the internationally recognized Amyloidosis Center at Boston University School of Medicine and Boston Medical Center. In this position, she played a key role in the multidisciplinary care of and coordination for patients with immunoglobulin light chain (AL) amyloidosis and related diseases. She returned to Yale New Haven Hospital to complete her fellowship in Medical Oncology and Hematology. Upon joining as faculty in the Hematology section at Yale School of Medicine, Dr. Browning was the sole awardee of the Bernard Forget Scholarship for 2020-2021, which supports deserving individuals who are transitioning into an academic career in Hematology.
Dr. Browning is a physician in the Smilow Multiple Myeloma and Gammopathies Programs and also sees patients in the Classical Hematology Clinic and she is incredibly passionate about the comprehensive management of patients with rare hematologic disorders including AL amyloidosis and hereditary hemorrhagic telangiectasia or HHT. Dr. Browning’s clinical and research interests include evaluating new treatments for multiple myeloma, AL amyloidosis, and other hematologic diseases and their impact on outcomes and quality of life for patients. With the support of the Frederick DeLuca Foundation and the DeLuca Center for Innovation in Hematology Research, she is also studying the association between metabolic syndrome, which can include obesity, high blood pressure, high cholesterol, and diabetes, and the development of monoclonal gammopathy and multiple myeloma with the aim to learn more about potential preventative strategies. Dr. Browning has a clinical and research interest in the management of issues such as bleeding and clotting in individuals with multiple myeloma and AL amyloidosis. Dr. Browning serves as the Principal Investigator on several clinical trials here at Yale for patients with multiple myeloma and AL amyloidosis and is interested in design of new clinical trials to further help her patients and others living with these diseases.
Dr. Browning serves as the representative for the Yale Cancer Center on the Faculty Advisory Council for Yale School of Medicine. She is a member of the American Society of Hematology (ASH), the International Myeloma Society (IMS), and the International Society of Amyloidosis (ISA). As a member of the HHT center here at Yale she is also a registered physician with CureHHT. Dr. Browning is dedicated to providing patient-centered and compassionate care to individuals and their families through a team-based approach. She is also committed to teaching trainees at various levels of medical training.
Departments & Organizations
- Cardiac Amyloidosis Program
- Hematology
- Internal Medicine
- Multiple Myeloma and Gammopathies Program
- Yale Cancer Center
- Yale Medicine
Education & Training
- Medical Oncology/Hematology Fellow
- Yale University School of Medicine (2020)
- Amyloid Fellow
- Boston University School of Medicine and Boston Medical Center (2017)
- Internal Medicine Intern/Resident
- Yale University School of Medicine (2016)
- MD
- University of Connecticut School of Medicine (2013)
- BS
- Quinnipiac University, Biology, Minors in Chemistry and Psychology (2009)
Research
Overview
Medical Research Interests
ORCID
0000-0002-9812-0654
Research at a Glance
Yale Co-Authors
Publications Timeline
Natalia Neparidze, MD
Noffar Bar, MD
Terri Parker, MD
Elan Gorshein, DO, JD, MPH
Tara Anderson
Stuart Seropian, MD
Publications
2024
Real-World Efficacy and Patient-Reported Quality of Life Outcomes with Daratumumab Regimens in Multiple Myeloma
Browning S, Li F, Theprungsirikul P, Parker T, Bar N, Giri S, Anderson T, Stevens E, Gorshein E, Sabbath K, Wei C, Ali S, Witt D, Persico J, Talsania A, Rahmat L, Kidwai W, Legare R, LaSala J, Austin M, Neparidze N. Real-World Efficacy and Patient-Reported Quality of Life Outcomes with Daratumumab Regimens in Multiple Myeloma. Blood 2024, 144: 7831. DOI: 10.1182/blood-2024-204150.Peer-Reviewed Original ResearchConceptsRelapsed/refractory multiple myelomaInternational Myeloma Working GroupAdverse eventsGlobal health statusFunctional scalesMultiple symptom scalesPartial responseProteasome inhibitorsMultiple myelomaHealth statusEastern Cooperative Oncology Group performance statusClinical trialsMonoclonal antibody targeting CD38Median progression free survivalRelapsed/refractory multiple myeloma patientsIntroduction of novel therapiesHealth-related quality of lifeClinical response assessmentDaratumumab-based regimensProgression free survivalInfusion-related reactionsLines of therapyPatient-reported quality of life outcomesMean fatigue scoreHealth-related qualityP-088 Evaluating T-cell Fitness Pre B-Cell Maturation Antigen (BCMA)-Targeted T-Cell Redirection Therapies (TRT) as a Predictive Marker for Efficacy/Toxicity in Relapsed/Refractory Multiple Myeloma (RRMM)
Theprungsirikul P, Yu M, Liu Y, Rall K, Matthews M, Neparidze N, Parker T, Browning S, Anderson T, Stevens E, Foss F, Gowda L, Pillai M, Isufi I, Seropian S, Mirza S, Bar N. P-088 Evaluating T-cell Fitness Pre B-Cell Maturation Antigen (BCMA)-Targeted T-Cell Redirection Therapies (TRT) as a Predictive Marker for Efficacy/Toxicity in Relapsed/Refractory Multiple Myeloma (RRMM). Clinical Lymphoma Myeloma & Leukemia 2024, 24: s92-s93. DOI: 10.1016/s2152-2650(24)01991-8.Peer-Reviewed Original ResearchPrevalence of metabolic comorbidities and viral co-infections in monoclonal gammopathy: a retrospective analysis
Muradashvili T, Yu M, Browning S, Bar N, Gorshein E, Parker T, Neparidze N. Prevalence of metabolic comorbidities and viral co-infections in monoclonal gammopathy: a retrospective analysis. Leukemia 2024, 38: 2281-2283. PMID: 39164408, DOI: 10.1038/s41375-024-02380-x.Peer-Reviewed Original ResearchAssociations of T-cell fitness prior to B-cell maturation antigen (BCMA)–targeted chimeric antigen receptor T-cell (CART) and bispecific T-cell engager (BiTE) therapies and efficacy/toxicity in relapsed/refractory multiple myeloma (RRMM).
Theprungsirikul P, Yu M, Rall K, Matthews M, Neparidze N, Parker T, Browning S, Anderson T, Stevens E, Foss F, Gowda L, Pillai M, Isufi I, Seropian S, Mirza S, Bar N. Associations of T-cell fitness prior to B-cell maturation antigen (BCMA)–targeted chimeric antigen receptor T-cell (CART) and bispecific T-cell engager (BiTE) therapies and efficacy/toxicity in relapsed/refractory multiple myeloma (RRMM). Journal Of Clinical Oncology 2024, 42: 7549-7549. DOI: 10.1200/jco.2024.42.16_suppl.7549.Peer-Reviewed Original ResearchConceptsChimeric antigen receptor T cellsRelapsed/refractory multiple myelomaT cell fitnessHigh-risk cytogeneticsCytokine release syndromeNon-respondersExtramedullary diseaseT cellsPeripheral blood prior to treatmentInternational Myeloma Working Group criteriaNR groupBlood prior to treatmentBispecific T-cell engagerMedian follow-up timeMedian prior linesT-cell therapyPost-treatment follow-upT-cell engagersT cell influxT-cell %Working Group criteriaYale Cancer CenterMann-Whitney U testResponse to disease progressionIdecabtagene vicleucel
2021
Outcomes Among Primary Refractory Multiple Myeloma Patients in the Era of Monoclonal Antibodies: The Yale Experience
Liu Y, Kywe B, Crawford L, Lora F, Bar N, Browning S, Gorshein E, Parker T, Neparidze N. Outcomes Among Primary Refractory Multiple Myeloma Patients in the Era of Monoclonal Antibodies: The Yale Experience. Blood 2021, 138: 1635. DOI: 10.1182/blood-2021-146619.Peer-Reviewed Original ResearchConceptsAutologous stem cell transplantMedian overall survivalInternational Staging System stage IIRefractory multiple myeloma patientsOverall survivalMultiple myeloma patientsMultiple myelomaInduction therapyPartial responsePrimary refractoryInduction regimenMyeloma patientsMonoclonal antibodiesPlasma cellsInternational Myeloma Working Group criteriaYale New Haven Health SystemStage IIHigh-risk cytogeneticsGood partial responseRetrospective cohort studyMajority of patientsMRD-negative statusMonoclonal antibody therapyStem cell transplantImportant prognostic valueUse of Denosumab after Zoledronic Acid in Patients with Multiple Myeloma: Real-World Experience from 2015 to 2019 at Yale Cancer Center
Dosani T, Poteraj A, Parker T, Bar N, Browning S, Gorshein E, Anderson T, Insogna K, Neparidze N. Use of Denosumab after Zoledronic Acid in Patients with Multiple Myeloma: Real-World Experience from 2015 to 2019 at Yale Cancer Center. Blood 2021, 138: 4756. DOI: 10.1182/blood-2021-147466.Peer-Reviewed Original ResearchConceptsBone-modifying agentsUse of denosumabYale Cancer CenterZoledronic acidMultiple myelomaMM patientsCancer CenterMedian numberPhysician preferenceCommon reasonClinical practiceNew fracturesNuclear factor kappa-B ligandStudy periodApproval of denosumabEfficacy of denosumabIncidence of SREsMain treatment centreSmilow Cancer HospitalSuppress bone turnoverPatient's renal functionBone resorption markersCohort of patientsGlomerular filtration rateDate of diagnosisEarly but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19
Briggs N, Gormally MV, Li F, Browning SL, Treggiari MM, Morrison A, Laurent-Rolle M, Deng Y, Hendrickson JE, Tormey CA, Desruisseaux MS. Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19. PLOS ONE 2021, 16: e0254453. PMID: 34320004, PMCID: PMC8318280, DOI: 10.1371/journal.pone.0254453.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsCOVID-19 convalescent plasmaSevere COVID-19Convalescent plasmaPlasma recipientsHospital mortalityUnexposed cohortCCP administrationSevere COVID-19 infectionPropensity score-matched analysisCOVID-19Limited therapeutic optionsCOVID-19 infectionCoronavirus disease 2019CCP recipientsHospital stayPrimary endpointSecondary endpointsHospital daysHospital dischargeEarly administrationComplete followMechanical ventilationTherapeutic optionsClinical differencesSevere diseaseForming the Hematology-Oncology Collaborative Videoconferencing (CO-VID) Learning Initiative: Experiential Lessons Learned From a Novel Trainee-Led Multidisciplinary Virtual Learning Platform
Martin RL, Grant MJ, Kimani S, Midha S, May J, Patell R, Collier E, Furfaro D, Bodine C, Reap L, Shah N, DeLaune J, Brusca S, Olazagasti C, Goyal S, Rubinstein S, Hakim N, Qin S, Browning SL, Sena L, Gilbert J, Davidson M, Lovly CM, Seetharamu N, Rangachari D, Murphy M, Chatwal M, Paschal R, Henry E, Collichio F, Green JR. Forming the Hematology-Oncology Collaborative Videoconferencing (CO-VID) Learning Initiative: Experiential Lessons Learned From a Novel Trainee-Led Multidisciplinary Virtual Learning Platform. JCO Oncology Practice 2021, 18: e36-e46. PMID: 34242082, PMCID: PMC8758064, DOI: 10.1200/op.20.00960.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsLearning initiativesVirtual education platformCOVID-19 curriculumGroup-level knowledgeMixed-methods surveyEducation platformExperiential lessonsLeadership traineesZoom conferenceInstructional segmentsMedical educationProgram facultyTraining institutionsConsensus needEducational initiativesLeadership skillsFormative processLearning modelConference evaluationsFaculty
2020
Spontaneous recovery in a patient with acquired thrombotic thrombocytopenic purpura (TTP): observation of a ‘subclinical’ TTP state
Browning S, Bahar B, Lee AI, Gorshein E. Spontaneous recovery in a patient with acquired thrombotic thrombocytopenic purpura (TTP): observation of a ‘subclinical’ TTP state. Hematology 2020, 25: 473-477. PMID: 33269995, DOI: 10.1080/16078454.2020.1848973.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsThrombotic thrombocytopenic purpuraMicroangiopathic haemolytic anaemiaADAMTS13 activity levelsPlasma exchangeHaemolytic anaemiaThrombocytopenic purpuraHaematologic parametersSpontaneous recoveryAcute thrombotic thrombocytopenic purpuraMild haemolytic anaemiaUrgent plasma exchangeInitiation of therapyHereditary thrombotic thrombocytopenic purpuraActivity levelsDeficiency of ADAMTS13High mortality rateClinical remissionDisease remissionThrombotic microangiopathyPrompt treatmentThrombotic manifestationsADAMTS13 inhibitorUrgent therapyAsymptomatic femalesClinical manifestations
2019
Daratumumab in the Clinic, a Real-Word Experience at Yale Cancer Center
Browning S, Parker T, Bar N, Seropian S, Lee A, Anderson T, Neparidze N. Daratumumab in the Clinic, a Real-Word Experience at Yale Cancer Center. Blood 2019, 134: 5569. DOI: 10.1182/blood-2019-130134.Peer-Reviewed Original ResearchConceptsSmilow Cancer HospitalMultiple myelomaRefractory MMInfusion reactionsSpeakers bureauCancer HospitalReal-word experienceReal-world practice patternsAnti-plasma cell therapyTransplant-eligible patientsYale Cancer CenterInfusion-related reactionsAdverse event profileLeukotriene receptor antagonistsProgression-free survivalRefractory multiple myelomaPatient-reported qualityManagement of patientsOverall response rateJanssen Scientific AffairsClonal plasma cellsExcellent safety profileMulti-center studyDrug combination regimensInfusion reaction rates
Clinical Trials
Current Trials
A Phase 3, Two-Stage, Randomized, Multicenter, Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Subjects With Relapsed or Refractory Multiple Myeloma (RRMM)
HIC ID2000033033RoleSub InvestigatorPrimary Completion Date06/18/2027Recruiting ParticipantsNovel Combination of Belantamab Mafodotin and Elotuzumab to Enhance Therapeutic Efficacy in Multiple Myeloma
HIC ID2000028918RoleSub InvestigatorPrimary Completion Date01/01/2025Recruiting ParticipantsDaratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma (DETER-SMM)
HIC ID2000025737RoleSub InvestigatorPrimary Completion Date12/31/2029Recruiting Participants
Academic Achievements & Community Involvement
activity American Society of Hematology
Professional OrganizationsMemberDetails07/01/2017 - Presentactivity American Society of Clinical Oncology
Professional OrganizationsMemberDetails07/01/2017 - Presentactivity International Myeloma Society
Professional OrganizationsMemberDetails07/01/2019 - Presentactivity International Society of Amyloidosis
Professional OrganizationsMemberDetails07/01/2018 - Presenthonor Forget Scholar 2020-2021
Other AwardYale Comprehensive Cancer Center and Section of HematologyDetails09/08/2020United States
Clinical Care
Overview
Sabrina Browning, MD, is a hematologist who cares for patients with blood disorders, including multiple myeloma, AL (light-chain) amyloidosis, and other monoclonal gammopathies. She also treats patients with benign hematologic conditions including problems with bleeding and clotting.
Dr. Browning says hematology is a field she has been passionate about ever since “the first time I saw blood cells on a blood smear under the microscope.”
She especially enjoys meeting with patients. She starts each new patient visit by taking the time to actively listen to their stories and concerns. “I feel extremely grateful for the opportunity to build close relationships with my patients and their families as we tackle challenges with their hematologic disorders,” says Dr. Browning. “Hematology is a field where research continues to advance care for patients with both hematologic cancers and benign hematologic conditions, and it is exciting to be able to bring this new knowledge directly to my patients.”
Dr. Browning's clinical and research interests include evaluating new treatments and their impact on quality of life. She has a special interest in inherited risk factors patients may have for developing these disorders, and the management of classical hematology issues, such as bleeding and clotting.
Dr. Browning works closely with colleagues to determine the best treatment strategies and incorporates patient input as well. She tells her patients, “We are a team, and I am committed to working with both you and your family to ensure you receive high-quality and personal care for your hematologic disease.”
Clinical Specialties
Fact Sheets
Multiple Myeloma
Learn More on Yale MedicineHereditary Hemorrhagic Telangiectasia (HHT)
Learn More on Yale MedicineAnemia
Learn More on Yale MedicineThrombocytopenia
Learn More on Yale Medicine
Board Certifications
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2016
Yale Medicine News
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News
- February 23, 2024
Department of Internal Medicine Promotions and Appointments (February 2024)
- December 05, 2023
Yale Cancer Center Physicians Bring Myeloma Message to Hamden’s Newhall Neighborhood
- September 14, 2023
Smilow Shares: AL Amyloidosis
- September 09, 2022
Blood Cancer Awareness Q&A with Sabrina Browning, MD
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Are You a Patient? View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.