1997
Intracellular acidosis activates c-Src
Yamaji Y, Tsuganezawa H, Moe OW, Alpern RJ. Intracellular acidosis activates c-Src. American Journal Of Physiology 1997, 272: c886-c893. PMID: 9124524, DOI: 10.1152/ajpcell.1997.272.3.c886.Peer-Reviewed Original ResearchConceptsC-SrcC-Src activationProtein tyrosine phosphatase inhibitorProtein tyrosine kinase pathwaysMedium acidificationTyrosine phosphatase inhibitorProtein tyrosine phosphorylationC-Src activityTyrosine kinase pathwayPhosphatase inhibitorPhosphotyrosine contentCell pH changesTyrosine phosphorylationCytosolic proteinsKinase pathwayRenal proximal tubule cell lineCellular responsesSodium orthovanadateNovel mechanismProximal tubule cell lineCell linesTubule cell lineCell acidificationSignificant activationActivation
1992
Induction of stress proteins in cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia.
Benjamin IJ, Horie S, Greenberg ML, Alpern RJ, Williams RS. Induction of stress proteins in cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia. Journal Of Clinical Investigation 1992, 89: 1685-1689. PMID: 1569208, PMCID: PMC443048, DOI: 10.1172/jci115768.Peer-Reviewed Original ResearchConceptsGlucose deprivationControl levelsATP depletionHeat shock protein 70Ischemic injuryHeat shock factorIschemic tissueIschemic cellsHigh-pressure liquid chromatographyHypoxia resultsM rotenoneC2 myogenic cellsStress proteinsMyogenic cellsNormoxic conditionsOxidative metabolismProtein 70ATP storesCultured myogenic cellsConsensus heat shock elementIschemiaATP poolHSF activationMajor stress proteinsDNA-binding activity