2019
Cholinergic Receptor Blockade in the VTA Attenuates Cue-Induced Cocaine-Seeking and Reverses the Anxiogenic Effects of Forced Abstinence
Nunes EJ, Bitner L, Hughley SM, Small KM, Walton SN, Rupprecht LE, Addy NA. Cholinergic Receptor Blockade in the VTA Attenuates Cue-Induced Cocaine-Seeking and Reverses the Anxiogenic Effects of Forced Abstinence. Neuroscience 2019, 413: 252-263. PMID: 31271832, PMCID: PMC6661179, DOI: 10.1016/j.neuroscience.2019.06.028.Peer-Reviewed Original ResearchConceptsCue-induced cocaineAnxiety-related behaviorDrug relapseOpen arm timeCholinergic receptor blockadeCocaine abstinenceVentral tegmental areaSubstance abuseSelf-administer intravenous cocaineMuscarinic receptor antagonist scopolaminePeriod of abstinenceAnxiogenic effectsReceptor blockadeCholinergic mechanismsCocaine-naïve ratsNicotinic acetylcholine receptor antagonist mecamylamineMale Sprague-Dawley ratsDrug abstinenceSprague-Dawley ratsDose-dependent increaseCocaine-naive ratsAntagonist scopolamineEPM behaviorSaline ratsAbstinence
2017
Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens
Martínez-Rivera A, Hao J, Tropea TF, Giordano TP, Kosovsky M, Rice RC, Lee A, Huganir RL, Striessnig J, Addy NA, Han S, Rajadhyaksha AM. Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens. Molecular Psychiatry 2017, 22: 1735-1745. PMID: 28194001, PMCID: PMC5555837, DOI: 10.1038/mp.2017.9.Peer-Reviewed Original ResearchMeSH KeywordsAffectAnimalsCalcium Channels, L-TypeCocaineCocaine-Related DisordersConditioning, PsychologicalDepressionDisease Models, AnimalDopamine Uptake InhibitorsGenetic Association StudiesHumansMaleMice, Inbred C57BLMice, TransgenicMotor ActivityNucleus AccumbensPost-Synaptic DensityReceptors, AMPASocial BehaviorVentral Tegmental AreaConceptsDepressive-like behaviorCav1.3 L-type Ca2L-type Ca2Receptor mechanismsCalcium-permeable α-aminoCACNA1D geneCav1.3 channelsRole of Cav1.3Depressive-like phenotypeMood-related behaviorsDepression-related phenotypesSocial behavioral deficitsNeuropsychiatric symptomsBehavioral deficitsMood disordersCP-AMPARNAc shellRodent studiesGluA1 phosphorylationHuman studiesNAc corePlace preferenceBipolar disorderPsychomotor activityCav1.3