2023
Ventral tegmental area M5 muscarinic receptors mediate effort-choice responding and nucleus accumbens dopamine in a sex-specific manner
Nunes E, Kebede N, Haight J, Foster D, Lindsley C, Conn P, Addy N. Ventral tegmental area M5 muscarinic receptors mediate effort-choice responding and nucleus accumbens dopamine in a sex-specific manner. Journal Of Pharmacology And Experimental Therapeutics 2023, 385: jpet-ar-2022-001438. PMID: 36828630, PMCID: PMC10108441, DOI: 10.1124/jpet.122.001438.Peer-Reviewed Original ResearchConceptsNucleus accumbens coreVentral tegmental areaM5 receptorsDA releaseMale ratsVTA infusionsDepressive disorderNucleus accumbensMuscarinic M5 receptorsSelective negative allosteric modulatorM5 muscarinic receptorsNegative allosteric modulatorsEffort-related choicePhasic DA releasePotential sex differencesSex-specific mannerACh toneVTA administrationCholinergic effectsMuscarinic receptorsFemale ratsTegmental areaPreclinical modelsDopamine releaseTherapeutic target
2017
Evaluating oral flavorant effects on nicotine self-administration behavior and phasic dopamine signaling
Wickham RJ, Nunes EJ, Hughley S, Silva P, Walton SN, Park J, Addy NA. Evaluating oral flavorant effects on nicotine self-administration behavior and phasic dopamine signaling. Neuropharmacology 2017, 128: 33-42. PMID: 28943284, PMCID: PMC5714675, DOI: 10.1016/j.neuropharm.2017.09.029.Peer-Reviewed Original ResearchConceptsSelf-administration behaviorNucleus accumbensNicotine self-administration behaviorIntravenous self-administration paradigmFast-scan cyclic voltammetryPublic health policy decisionsPhasic DA signalingTobacco product useProgressive ratio taskSelf-administration paradigmTwo-bottle choice testPhasic DA releaseHealth policy decisionsTobacco product regulationOral mentholOral nicotineOral sucroseNicotine administrationPreclinical findingsDA releaseMale ratsOral administrationSmoking behaviorNicotine aversionMenthol effects