2020
NAguideR: performing and prioritizing missing value imputations for consistent bottom-up proteomic analyses
Wang S, Li W, Hu L, Cheng J, Yang H, Liu Y. NAguideR: performing and prioritizing missing value imputations for consistent bottom-up proteomic analyses. Nucleic Acids Research 2020, 48: e83-e83. PMID: 32526036, PMCID: PMC7641313, DOI: 10.1093/nar/gkaa498.Peer-Reviewed Original Research
2017
A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability
Tan SLW, Chadha S, Liu Y, Gabasova E, Perera D, Ahmed K, Constantinou S, Renaudin X, Lee M, Aebersold R, Venkitaraman AR. A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability. Cell 2017, 169: 1105-1118.e15. PMID: 28575672, PMCID: PMC5457488, DOI: 10.1016/j.cell.2017.05.010.Peer-Reviewed Original ResearchConceptsBRCA2 haploinsufficiencyChromosomal aberrationsBRCA2 mutation carriersDNA replication forksReplication fork instabilityStructural chromosomal aberrationsRNA-DNA hybridsMutation carriersFork instabilityBRCA2 expressionEndogenous toxinsHeterozygous mutationsGenome instabilityReplication forksCellular proteinsDNA replicationCancer susceptibilityProteasomal degradationUbiquitous environmental toxinSingle copySpontaneous mutagenesisMechanisms of toxicityTransient exposureEnvironmental toxinsTumor suppressor