2015
Prediction of colorectal cancer diagnosis based on circulating plasma proteins
Surinova S, Choi M, Tao S, Schüffler PJ, Chang CY, Clough T, Vysloužil K, Khoylou M, Srovnal J, Liu Y, Matondo M, Hüttenhain R, Weisser H, Buhmann JM, Hajdúch M, Brenner H, Vitek O, Aebersold R. Prediction of colorectal cancer diagnosis based on circulating plasma proteins. EMBO Molecular Medicine 2015, 7: 1166-1178. PMID: 26253081, PMCID: PMC4568950, DOI: 10.15252/emmm.201404873.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorClinical Laboratory TechniquesColorectal NeoplasmsHumansMass SpectrometryPlasmaConceptsColorectal cancer diagnosisBlood-based markersColorectal cancer detectionPatient's systemic circulationColorectal cancerSystemic circulationIndependent cohortCritical clinical needNon-invasive detectionDiagnostic valueClinical needTissue epitheliumCancer diagnosisPlasma samplesBiomarker signaturesPlasma proteinsBlood plasmaProtein biomarkersCancer detectionCandidate glycoproteinsClinical datasetsMass spectrometry-based approachCohortCancerDiagnosis
2014
Glycoproteomic Analysis of Prostate Cancer Tissues by SWATH Mass Spectrometry Discovers N-acylethanolamine Acid Amidase and Protein Tyrosine Kinase 7 as Signatures for Tumor Aggressiveness*
Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R. Glycoproteomic Analysis of Prostate Cancer Tissues by SWATH Mass Spectrometry Discovers N-acylethanolamine Acid Amidase and Protein Tyrosine Kinase 7 as Signatures for Tumor Aggressiveness*. Molecular & Cellular Proteomics 2014, 13: 1753-1768. PMID: 24741114, PMCID: PMC4083113, DOI: 10.1074/mcp.m114.038273.Peer-Reviewed Original ResearchConceptsN-acylethanolamine acid amidaseProtein tyrosine kinase 7Non-aggressive prostate cancerTyrosine kinase 7Prostate cancerKinase 7N-glycositesDiverse biological processesPotential tissue biomarkersAggressive prostate cancerPCa tumor tissuesSWATH mass spectrometryTissue microarray analysisProstate cancer tissuesUrgent clinical needIdentification of biomarkersHuman proteomePCa aggressivenessMicroarray analysisBiological processesPCa casesTissue biomarkersTumor aggressivenessNormal prostateCancer tissues
2013
Mass spectrometric protein maps for biomarker discovery and clinical research
Liu Y, Hüttenhain R, Collins B, Aebersold R. Mass spectrometric protein maps for biomarker discovery and clinical research. Expert Review Of Molecular Diagnostics 2013, 13: 811-825. PMID: 24138574, PMCID: PMC3833812, DOI: 10.1586/14737159.2013.845089.Peer-Reviewed Original Research
2012
Integrative Proteomics and Tissue Microarray Profiling Indicate the Association between Overexpressed Serum Proteins and Non-Small Cell Lung Cancer
Liu Y, Luo X, Hu H, Wang R, Sun Y, Zeng R, Chen H. Integrative Proteomics and Tissue Microarray Profiling Indicate the Association between Overexpressed Serum Proteins and Non-Small Cell Lung Cancer. PLOS ONE 2012, 7: e51748. PMID: 23284758, PMCID: PMC3526638, DOI: 10.1371/journal.pone.0051748.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerTissue microarray analysisCell lung cancerLung cancerLung cancer patientsPotential serum biomarkersSerum proteinsBlood levelsCancer deathCancer patientsSerum biomarkersTissue microarray profilingAlpha 1BTumor sectionsSignificant associationCancerEarly detectionSerum proteomics datasetMultiple reaction monitoringPatientsMicroarray profilingLabel-free quantitative proteomicsAbnormal biological processesHealthy casesMicroarray analysis
2011
A high-quality secretome of A549 cells aided the discovery of C4b-binding protein as a novel serum biomarker for non-small cell lung cancer
Luo X, Liu Y, Wang R, Hu H, Zeng R, Chen H. A high-quality secretome of A549 cells aided the discovery of C4b-binding protein as a novel serum biomarker for non-small cell lung cancer. Journal Of Proteomics 2011, 74: 528-538. PMID: 21262398, DOI: 10.1016/j.jprot.2011.01.011.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerCellular proteomeCell lung cancerCancer secretomeLung cancerOne-dimensional gel electrophoresisA549 cellsBiomarker discoveryProteomic dataGene expressionSecretory proteinsIntracellular contaminationNovel promising biomarkerNovel serum biomarkersEnzyme-linked immunosorbent assaySecretomeProteinSerum proteomic dataClinical stagingProteomeSerum biomarkersGel electrophoresisC4BP levelsPromising biomarkerImmunosorbent assay