2014
Glycoproteomic Analysis of Prostate Cancer Tissues by SWATH Mass Spectrometry Discovers N-acylethanolamine Acid Amidase and Protein Tyrosine Kinase 7 as Signatures for Tumor Aggressiveness*
Liu Y, Chen J, Sethi A, Li QK, Chen L, Collins B, Gillet LC, Wollscheid B, Zhang H, Aebersold R. Glycoproteomic Analysis of Prostate Cancer Tissues by SWATH Mass Spectrometry Discovers N-acylethanolamine Acid Amidase and Protein Tyrosine Kinase 7 as Signatures for Tumor Aggressiveness*. Molecular & Cellular Proteomics 2014, 13: 1753-1768. PMID: 24741114, PMCID: PMC4083113, DOI: 10.1074/mcp.m114.038273.Peer-Reviewed Original ResearchConceptsN-acylethanolamine acid amidaseProtein tyrosine kinase 7Non-aggressive prostate cancerTyrosine kinase 7Prostate cancerKinase 7N-glycositesDiverse biological processesPotential tissue biomarkersAggressive prostate cancerPCa tumor tissuesSWATH mass spectrometryTissue microarray analysisProstate cancer tissuesUrgent clinical needIdentification of biomarkersHuman proteomePCa aggressivenessMicroarray analysisBiological processesPCa casesTissue biomarkersTumor aggressivenessNormal prostateCancer tissues
2012
Integrative Proteomics and Tissue Microarray Profiling Indicate the Association between Overexpressed Serum Proteins and Non-Small Cell Lung Cancer
Liu Y, Luo X, Hu H, Wang R, Sun Y, Zeng R, Chen H. Integrative Proteomics and Tissue Microarray Profiling Indicate the Association between Overexpressed Serum Proteins and Non-Small Cell Lung Cancer. PLOS ONE 2012, 7: e51748. PMID: 23284758, PMCID: PMC3526638, DOI: 10.1371/journal.pone.0051748.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerTissue microarray analysisCell lung cancerLung cancerLung cancer patientsPotential serum biomarkersSerum proteinsBlood levelsCancer deathCancer patientsSerum biomarkersTissue microarray profilingAlpha 1BTumor sectionsSignificant associationCancerEarly detectionSerum proteomics datasetMultiple reaction monitoringPatientsMicroarray profilingLabel-free quantitative proteomicsAbnormal biological processesHealthy casesMicroarray analysis