A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability
Tan SLW, Chadha S, Liu Y, Gabasova E, Perera D, Ahmed K, Constantinou S, Renaudin X, Lee M, Aebersold R, Venkitaraman AR. A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability. Cell 2017, 169: 1105-1118.e15. PMID: 28575672, PMCID: PMC5457488, DOI: 10.1016/j.cell.2017.05.010.Peer-Reviewed Original ResearchConceptsBRCA2 haploinsufficiencyChromosomal aberrationsBRCA2 mutation carriersDNA replication forksReplication fork instabilityStructural chromosomal aberrationsRNA-DNA hybridsMutation carriersFork instabilityBRCA2 expressionEndogenous toxinsHeterozygous mutationsGenome instabilityReplication forksCellular proteinsDNA replicationCancer susceptibilityProteasomal degradationUbiquitous environmental toxinSingle copySpontaneous mutagenesisMechanisms of toxicityTransient exposureEnvironmental toxinsTumor suppressor