2018
Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS
Sajic T, Liu Y, Arvaniti E, Surinova S, Williams EG, Schiess R, Hüttenhain R, Sethi A, Pan S, Brentnall TA, Chen R, Blattmann P, Friedrich B, Niméus E, Malander S, Omlin A, Gillessen S, Claassen M, Aebersold R. Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS. Cell Reports 2018, 23: 2819-2831.e5. PMID: 29847809, DOI: 10.1016/j.celrep.2018.04.114.Peer-Reviewed Original ResearchConceptsN-glycoproteinsAvailable proteomic dataSWATH mass spectrometryImmense clinical interestCancer-type specificProteomic changesProteomic dataN-glycositesProteomic workflowParticular carcinomaProtein compositionClinical stageMetastatic stageBlood samplesPatient plasmaSolid carcinomasEarly cancer detectionSWATH-MSTumor tissueSystemic responseCarcinomaProteinEarly detectionClinical interestCancer
2012
Integrative Proteomics and Tissue Microarray Profiling Indicate the Association between Overexpressed Serum Proteins and Non-Small Cell Lung Cancer
Liu Y, Luo X, Hu H, Wang R, Sun Y, Zeng R, Chen H. Integrative Proteomics and Tissue Microarray Profiling Indicate the Association between Overexpressed Serum Proteins and Non-Small Cell Lung Cancer. PLOS ONE 2012, 7: e51748. PMID: 23284758, PMCID: PMC3526638, DOI: 10.1371/journal.pone.0051748.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerTissue microarray analysisCell lung cancerLung cancerLung cancer patientsPotential serum biomarkersSerum proteinsBlood levelsCancer deathCancer patientsSerum biomarkersTissue microarray profilingAlpha 1BTumor sectionsSignificant associationCancerEarly detectionSerum proteomics datasetMultiple reaction monitoringPatientsMicroarray profilingLabel-free quantitative proteomicsAbnormal biological processesHealthy casesMicroarray analysis
2010
Proteomic mining in the dysplastic liver of WHV/c‐myc mice – insights and indicators for early hepatocarcinogenesis
Liu Y, Li C, Xing Z, Yuan X, Wu Y, Xu M, Tu K, Li Q, Wu C, Zhao M, Zeng R. Proteomic mining in the dysplastic liver of WHV/c‐myc mice – insights and indicators for early hepatocarcinogenesis. The FEBS Journal 2010, 277: 4039-4053. PMID: 20807235, DOI: 10.1111/j.1742-4658.2010.07795.x.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaMouse modelFK506-binding protein 4C-myc miceTransgenic mouse modelEarly HCC diagnosisAsymptomatic processC-myc-induced hepatocarcinogenesisDysplastic liversFerritin heavy chainHCC diagnosisTissue microarrayImmunohistochemical analysisStage IIITumor onsetPutative biomarkersSerum samplesWestern blottingEarly detectionControl casesEarly hepatocarcinogenesisProtein 4Cancer initiationProtein expression profilesDysplastic stage