2016
Mechanism of substrate specificity of phosphatidylinositol phosphate kinases
Muftuoglu Y, Xue Y, Gao X, Wu D, Ha Y. Mechanism of substrate specificity of phosphatidylinositol phosphate kinases. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 8711-8716. PMID: 27439870, PMCID: PMC4978281, DOI: 10.1073/pnas.1522112113.Peer-Reviewed Original ResearchConceptsPhosphatidylinositol phosphate kinaseKinase familySubstrate specificityPhosphate kinasePhosphatidylinositol phosphate kinase (PIPK) familyZebrafish type IMembrane trafficking processesExquisite substrate specificityType III kinaseEukaryotic cellsInositol ringPhosphorylation resultsSubstrate recognitionTrafficking processesSpecificity loopPhosphatidylinositol derivativesBiological functionsPhosphatidylinositol 4PhosphatidylinositolKinaseStructural motifsType IBisphosphateLoop functionsComplex patterns
2004
The X-Ray Structure of an Antiparallel Dimer of the Human Amyloid Precursor Protein E2 Domain
Wang Y, Ha Y. The X-Ray Structure of an Antiparallel Dimer of the Human Amyloid Precursor Protein E2 Domain. Molecular Cell 2004, 15: 343-353. PMID: 15304215, DOI: 10.1016/j.molcel.2004.06.037.Peer-Reviewed Original ResearchConceptsMembrane protein precursorsX-ray structureSpectrin familyHeparan sulfate proteoglycanDimer interfaceBiological functionsStructure of E2Protein structureProtein precursorPutative ligandE2 domainContinuous helixExtracellular matrixUnexpected resemblanceAntiparallel dimerSulfate proteoglycanAntiparallel orientationPrecursor presentDomainBindsHelixDimerizationSecond monomer