2021
ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes
Shi F, Mendrola JM, Sheetz JB, Wu N, Sommer A, Speer KF, Noordermeer JN, Kan ZY, Perry K, Englander SW, Stayrook SE, Fradkin LG, Lemmon MA. ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes. Cell Reports 2021, 37: 109834. PMID: 34686333, PMCID: PMC8650758, DOI: 10.1016/j.celrep.2021.109834.Peer-Reviewed Original ResearchAnimalsDrosophila melanogasterDrosophila ProteinsModels, MolecularNerve Tissue ProteinsProtein BindingProtein ConformationProtein Interaction Domains and MotifsProtein-Tyrosine KinasesProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesSf9 CellsStructure-Activity RelationshipWnt ProteinsWnt Signaling Pathway
2008
Crystal structure of the λ repressor and a model for pairwise cooperative operator binding
Stayrook S, Jaru-Ampornpan P, Ni J, Hochschild A, Lewis M. Crystal structure of the λ repressor and a model for pairwise cooperative operator binding. Nature 2008, 452: 1022-1025. PMID: 18432246, DOI: 10.1038/nature06831.Peer-Reviewed Original ResearchStructural basis for the function and inhibition of an influenza virus proton channel
Stouffer A, Acharya R, Salom D, Levine A, Di Costanzo L, Soto C, Tereshko V, Nanda V, Stayrook S, DeGrado W. Structural basis for the function and inhibition of an influenza virus proton channel. Nature 2008, 451: 596-599. PMID: 18235504, PMCID: PMC3889492, DOI: 10.1038/nature06528.Peer-Reviewed Original Research
2006
The Structural Basis of Cooperative Regulation at an Alternate Genetic Switch
Pinkett H, Shearwin K, Stayrook S, Dodd I, Burr T, Hochschild A, Egan J, Lewis M. The Structural Basis of Cooperative Regulation at an Alternate Genetic Switch. Molecular Cell 2006, 21: 605-615. PMID: 16507359, DOI: 10.1016/j.molcel.2006.01.019.Peer-Reviewed Original ResearchConceptsGenetic switchC-terminal domainTemperate bacteriophagesCooperativity mutantsBacteriophage lambdaGene regulationRegulatory regionsRepressor monomersGenetic screeningGenetic studiesMolecular basisRepressorStructural basisRegulatory activityBacteriophageCooperative regulationRegulationLambdaMutantsGenesTemperate