Heparin Displaces Interferon-γ–Inducible Chemokines (IP-10, I-TAC, and Mig) Sequestered in the Vasculature and Inhibits the Transendothelial Migration and Arterial Recruitment of T Cells
Ranjbaran H, Wang Y, Manes TD, Yakimov AO, Akhtar S, Kluger MS, Pober JS, Tellides G. Heparin Displaces Interferon-γ–Inducible Chemokines (IP-10, I-TAC, and Mig) Sequestered in the Vasculature and Inhibits the Transendothelial Migration and Arterial Recruitment of T Cells. Circulation 2006, 114: 1293-1300. PMID: 16940188, DOI: 10.1161/circulationaha.106.631457.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Inflammatory AgentsCell MovementCells, CulturedChemokine CXCL10Chemokine CXCL11Chemokine CXCL9ChemokinesChemokines, CXCCoronary Artery DiseaseCoronary VesselsEndothelium, VascularHeparinHeparin AntagonistsHumansInterferon-gammaInterleukin-12ProtaminesProtein BindingReceptors, ChemokineReceptors, CXCR3Th1 CellsT-LymphocytesConceptsIP-10Heparin administrationCoronary arteryEndothelial cellsI-TACT cellsIFN-gamma-dependent productionTh1-type inflammatory diseasesI-TAC/CXCL11IP-10/CXCL10IFN-gamma-producing Th1 cellsTransendothelial migrationInflammatory arterial diseaseNonanticoagulant heparin derivativesCoronary artery bypassChemokines IP-10/CXCL10Memory T cellsT helper cellsMIG/CXCL9IFN-gamma responsesEffect of heparinAtherosclerotic coronary arteriesHuman coronary arteriesImmunodeficient mouse hostsCultured endothelial cells