Intracellular Metabolism and Persistence of the Anti-Human Immunodeficiency Virus Activity of 2′,3′-Didehydro-3′-Deoxy-4′-Ethynylthymidine, a Novel Thymidine Analog
Paintsil E, Dutschman GE, Hu R, Grill SP, Lam W, Baba M, Tanaka H, Cheng YC. Intracellular Metabolism and Persistence of the Anti-Human Immunodeficiency Virus Activity of 2′,3′-Didehydro-3′-Deoxy-4′-Ethynylthymidine, a Novel Thymidine Analog. Antimicrobial Agents And Chemotherapy 2007, 51: 3870-3879. PMID: 17724147, PMCID: PMC2151449, DOI: 10.1128/aac.00692-07.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsCell LineDideoxynucleotidesDose-Response Relationship, DrugHeLa CellsHIVHumansPhosphorylationReverse Transcriptase InhibitorsStavudineThymine NucleotidesVirus ReplicationZidovudineConceptsAnti-human immunodeficiency virus (HIV) activityAnti-HIV activityDrug-resistant virusesD4TNovel thymidine analogVirus activityPotent anti-human immunodeficiency virus activityMultidrug-resistant HIVCurrent antiretroviral therapyDrug removalPatient compliance issuesIntracellular metabolismThymidine analogueLong-term toxicityPromising antiviral candidateNovel antiretroviral compoundsDose-dependent accumulationAntiretroviral therapyMonophosphate metaboliteFrequent dosingAntiretroviral compoundsT metabolitesTherapeutic benefitHIV activityAntiviral candidates