1996
KN-62, a calcium/calmodulin-dependent protein kinase II inhibitor, inhibits high potassium-stimulated prolactin secretion and intracellular calcium increases in anterior pituitary cells
Cui Z, Hidaka H, Dannies P. KN-62, a calcium/calmodulin-dependent protein kinase II inhibitor, inhibits high potassium-stimulated prolactin secretion and intracellular calcium increases in anterior pituitary cells. Biochimica Et Biophysica Acta 1996, 1310: 343-347. PMID: 8599613, DOI: 10.1016/0167-4889(95)00170-0.Peer-Reviewed Original ResearchMeSH Keywords1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAnimalsCalciumCalcium-Calmodulin-Dependent Protein KinasesCells, CulturedEnzyme InhibitorsFemaleIsoquinolinesKineticsPiperazinesPituitary Gland, AnteriorPotassiumPotassium ChlorideProlactinRatsRats, Sprague-DawleyThyrotropin-Releasing HormoneTime FactorsConceptsAnterior pituitary cellsProlactin secretionCalcium/calmodulin-dependent protein kinase IIPituitary cellsCalmodulin-dependent protein kinase IIKN-04KN-62Rat anterior pituitary cellsVoltage-dependent calcium channelsProtein kinase IICalmodulin-dependent protein kinase II inhibitorKCl-stimulated increasesIntracellular calcium increaseCalcium/calmodulin-dependent protein kinase II inhibitorKinase II inhibitorCalcium channelsCalcium increaseIntracellular Ca2Kinase IISecretionInhibits activationII inhibitorsIC50InhibitorsCells
1992
Thyrotropin-releasing hormone-mediated Mn2+ entry in perifused rat anterior pituitary cells
Cui Z, Dannies P. Thyrotropin-releasing hormone-mediated Mn2+ entry in perifused rat anterior pituitary cells. Biochemical Journal 1992, 283: 507-513. PMID: 1575695, PMCID: PMC1131064, DOI: 10.1042/bj2830507.Peer-Reviewed Original ResearchConceptsAnterior pituitary cellsRat anterior pituitary cellsPituitary cellsMicroM dopaminePerifused anterior pituitary cellsIndo-1-loaded cellsReceptor-mediated Ca2Action of TRHContinuous TRH infusionTRH infusionCation entryIntracellular Ca2Indo-1TRHTumor promotorFree mediumG proteinsUnstimulated cellsCell typesDopamineCa2CellsLittle effectInsensitive wavelengthInfusion
1988
TRH and BAY K 8644 synergistically stimulate prolactin release but not 45Ca2+ uptake
Pachter J, Law G, Dannies P. TRH and BAY K 8644 synergistically stimulate prolactin release but not 45Ca2+ uptake. American Journal Of Physiology 1988, 255: c633-c640. PMID: 2461093, DOI: 10.1152/ajpcell.1988.255.5.c633.Peer-Reviewed Original ResearchConceptsBay K 8644Thyrotropin-releasing hormoneProlactin secretionAngiotensin IIProlactin releaseChannel agonist Bay K 8644Agonist Bay K 8644Rat anterior pituitary cellsFluorescent indicator indo-1Anterior pituitary cellsDihydropyridine-sensitive Ca2Indicator indo-1Primary cultured cellsSecretory peaksPituitary cellsSubsequent stimulationIndo-1Transient increaseCytosolic Ca2GH4C1 cellsPrimary culturesSecretionUntreated cellsAdditional effectCultured cellsDopamine has no Effect on Thyrotropin-Releasing Hormone Mobilization of Calcium from Intracellular Stores in Rat Anterior Pituitary Cells
Law G, Pachter J, Dannies P. Dopamine has no Effect on Thyrotropin-Releasing Hormone Mobilization of Calcium from Intracellular Stores in Rat Anterior Pituitary Cells. Endocrinology 1988, 2: 966-972. PMID: 3141796, DOI: 10.1210/mend-2-10-966.Peer-Reviewed Original ResearchConceptsRat anterior pituitary cellsAnterior pituitary cellsPRL secretionPituitary cellsIntracellular Ca2Intracellular storesLow Ca2MM Ca2Inhibition of releaseDopaminergic reductionSource of Ca2PRL releaseIntracellular calciumNM TRHPerifusion systemExtracellular Ca2MicroM dopamineTRHInternal Ca2DopamineEnriched populationMM KClSecretionInositol phosphatesCa2
1986
Antiestrogens are partial estrogen agonists for prolactin production in primary pituitary cultures
Martinez-Campos A, Amara J, Dannies P. Antiestrogens are partial estrogen agonists for prolactin production in primary pituitary cultures. Molecular And Cellular Endocrinology 1986, 48: 127-133. PMID: 3803705, DOI: 10.1016/0303-7207(86)90035-3.Peer-Reviewed Original ResearchConceptsProlactin productionPituitary cellsMale rat anterior pituitary cellsRat anterior pituitary cellsPartial estrogen agonistNormal pituitary cellsAnterior pituitary cellsConcentrations of estradiolDose-response relationshipPrimary pituitary culturesEstrogen antagonistLY 117018Estrogen agonistM tamoxifenPartial agonistPituitary culturesEstrogen inductionTamoxifenMaximal stimulationFull antagonistM LysPrimary culturesStimulationPimozideAgonists
1985
Stimulation of the Adenosine 3′,5′-Monophosphate and the Ca2+ Messenger Systems Together Reverse Dopaminergic Inhibition of Prolactin Release*
DELBEKE D, DANNIES P. Stimulation of the Adenosine 3′,5′-Monophosphate and the Ca2+ Messenger Systems Together Reverse Dopaminergic Inhibition of Prolactin Release*. Endocrinology 1985, 117: 439-446. PMID: 2990850, DOI: 10.1210/endo-117-2-439.Peer-Reviewed Original ResearchConceptsPRL releaseDopaminergic inhibitionAbsence of dopamineMessenger systemsRat anterior pituitary cellsPattern of releaseAnterior pituitary cellsCAMP messenger systemMin of preincubationBasal releaseProlactin releaseNM TRHPituitary cellsIntracellular Ca2Sustained phasePhorbol ester 12Cytosolic Ca2Intracellular cAMPTRHAdenylate cyclaseCAMP levelsDopamineSustained releaseLevel of releaseC-kinase activity
1983
Veratridine and Ouabain Stimulate Calcium-Dependent Prolactin Release*
SCAMMELL J, DANNIES P. Veratridine and Ouabain Stimulate Calcium-Dependent Prolactin Release*. Endocrinology 1983, 113: 1228-1235. PMID: 6617570, DOI: 10.1210/endo-113-4-1228.Peer-Reviewed Original ResearchConceptsPRL releaseCalcium channel blocker D600Rat anterior pituitary cellsTetrodotoxin-insensitive mechanismCalcium channel blockersChannel blocker tetrodotoxinDopaminergic agonist bromocriptineEffect of veratridineAnterior pituitary cellsAction of veratridineChannel blocker D600Blocker tetrodotoxinAgonist bromocriptineProlactin releaseChannel blockersVeratridine effectPituitary cellsChannel activatorVeratridineGH4C1 cellsPrimary culturesOuabainNormal cellsStimulationPreincubation
1980
Dopaminergic inhibition of ionophore A23187-stimulated release of prolactin from rat anterior pituitary cells.
Tam S, Dannies P. Dopaminergic inhibition of ionophore A23187-stimulated release of prolactin from rat anterior pituitary cells. Journal Of Biological Chemistry 1980, 255: 6595-6599. PMID: 6771274, DOI: 10.1016/s0021-9258(18)43611-3.Peer-Reviewed Original ResearchConceptsRat anterior pituitary cellsAnterior pituitary cellsRelease of prolactinDopaminergic inhibitionPituitary cellsProlactin
1979
Antipsychotic Drugs Inhibit Prolactin Release from Rat Anterior Pituitary Cells in Culture by a Mechanism Not Involving the Dopamine Receptor*
WEST B, DANNIES P. Antipsychotic Drugs Inhibit Prolactin Release from Rat Anterior Pituitary Cells in Culture by a Mechanism Not Involving the Dopamine Receptor*. Endocrinology 1979, 104: 877-880. PMID: 436760, DOI: 10.1210/endo-104-4-877.Peer-Reviewed Original ResearchConceptsRat anterior pituitary cellsAnterior pituitary cellsGH releasePRL releaseControl valuesAntipsychotic drugsDopamine antagonistsDopamine receptorsPituitary cellsInhibition of PRLMicroM pimozideDopamine agonistsHormone releaseD-butaclamolInhibited secretionPRLBromocriptineAntagonistButaclamolInhibitionReceptorsDrugsReleaseCellsHaloperidol