2010
Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension
Rajkumar R, Konishi K, Richards TJ, Ishizawar DC, Wiechert AC, Kaminski N, Ahmad F. Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension. AJP Heart And Circulatory Physiology 2010, 298: h1235-h1248. PMID: 20081107, PMCID: PMC2853417, DOI: 10.1152/ajpheart.00254.2009.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionIdiopathic pulmonary fibrosisPathogenesis of PAHIdiopathic pulmonary arterial hypertensionPulmonary hypertensionArterial hypertensionRegulation of actinThrombospondin type 1 motif 9Pulmonary arteriolar remodelingSecondary pulmonary hypertensionCoagulation factor II receptorDistinct pathophysiological mechanismsLife-threatening conditionDistinct gene expression signaturesEstrogen receptor 1Nuclear receptor coactivator 2RNA expression profilesPurinergic receptor P2YGenomewide microarray analysisPlatelet factor 4RNA expression profilingHigh expression levelsOncogene homolog 1Gene expression signaturesProtein ubiquitination
2008
Network analysis of temporal effects of intermittent and sustained hypoxia on rat lungs
Wu W, Dave NB, Yu G, Strollo PJ, Kovkarova-Naumovski E, Ryter SW, Reeves SR, Dayyat E, Wang Y, Choi AM, Gozal D, Kaminski N. Network analysis of temporal effects of intermittent and sustained hypoxia on rat lungs. Physiological Genomics 2008, 36: 24-34. PMID: 18826996, PMCID: PMC2604785, DOI: 10.1152/physiolgenomics.00258.2007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEstrogen Receptor alphaGene Expression ProfilingGene Regulatory NetworksHypoxiaLungMaleMicroarray AnalysisRatsRats, Sprague-DawleyConceptsSystems biology approachEstrogen receptor 1Lung responseQuantitative real-time PCRRat lungBiology approachIntermittent hypoxiaExpression patternsSustained hypoxiaReal-time PCRDistinct gene expression patternsDifferent temporal expression patternsDownstream physiological effectsGene expression patternsTemporal expression patternsSteroid hormone receptor activityGene expression profilesTemporal expression changesRegulatory networksHormone receptor activityPulmonary hypertensionKey proteinsGene expressionMolecular networksExpression changes