2024
Challenges and Opportunities for Commercializing Technologies in the Pulmonary Arena: An Official American Thoracic Society Report
Vukmirovic M, Benam K, Rose J, Turner S, Magin C, Lagares D, Cohen A, Kaminski N, Hirota J, Maher T, Konigshoff M, Mallampalli R, Sheppard D, Tarran R, Gomer R, Kenyon N, Morris D, Hobbie S, Raju S, Petrache I, Watkins T, Kumar R, Lam W, Sherer T, Hecker L. Challenges and Opportunities for Commercializing Technologies in the Pulmonary Arena: An Official American Thoracic Society Report. Annals Of The American Thoracic Society 2024, 21: 1-11. PMID: 37903340, PMCID: PMC10867911, DOI: 10.1513/annalsats.202310-872st.Peer-Reviewed Original Research
2020
Expression of SARS-CoV-2 receptor ACE2 and coincident host response signature varies by asthma inflammatory phenotype
Camiolo M, Gauthier M, Kaminski N, Ray A, Wenzel SE. Expression of SARS-CoV-2 receptor ACE2 and coincident host response signature varies by asthma inflammatory phenotype. Journal Of Allergy And Clinical Immunology 2020, 146: 315-324.e7. PMID: 32531372, PMCID: PMC7283064, DOI: 10.1016/j.jaci.2020.05.051.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAngiotensin-Converting Enzyme 2AsthmaBetacoronavirusBiomarkersBronchiBronchoalveolar Lavage FluidCohort StudiesCoronavirus InfectionsCOVID-19EosinophilsFemaleGene Expression ProfilingHumansInterferon Type IInterferon-gammaMaleMiddle AgedPandemicsPeptidyl-Dipeptidase APneumonia, ViralProtein Interaction MappingReceptors, VirusRisk FactorsSARS-CoV-2Severity of Illness IndexT-LymphocytesTranscriptomeUnited StatesConceptsCoronavirus disease 2019Severe coronavirus disease 2019Subset of patientsDisease 2019Risk factorsBronchial epitheliumAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSevere acute respiratory syndrome coronavirus 2Syndrome coronavirus 2 infectionType 2 inflammatory biomarkersAcute respiratory syndrome coronavirus 2Receptor ACE2SARS-CoV-2 receptor ACE2Respiratory syndrome coronavirus 2Asthma inflammatory phenotypesLarge asthma cohortsLower peripheral bloodT cell-activating factorCoronavirus 2 infectionEnzyme 2 (ACE2) expressionHistory of hypertensionDiagnosis of asthmaBronchoalveolar lavage lymphocytesT cell recruitment
2019
Climate change and lung health: presidential failure, professional responsibility
Hopkinson NS, Hart N, Jenkins G, Rosenfeld M, Smyth AR, Wilkinson AJK, Kaminski N. Climate change and lung health: presidential failure, professional responsibility. Thorax 2019, 74: 627-628. PMID: 31010935, DOI: 10.1136/thoraxjnl-2019-213184.Peer-Reviewed Original ResearchHigh-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research. An Official American Thoracic Society Workshop Report
Hersh CP, Adcock IM, Celedón JC, Cho MH, Christiani DC, Himes BE, Kaminski N, Mathias RA, Meyers DA, Quackenbush J, Redline S, Steiling KA, Tabor HK, Tobin MD, Wurfel MM, Yang IV, Koppelman GH. High-Throughput Sequencing in Respiratory, Critical Care, and Sleep Medicine Research. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2019, 16: 1-16. PMID: 30592451, PMCID: PMC6812157, DOI: 10.1513/annalsats.201810-716ws.Peer-Reviewed Original ResearchConceptsCritical careSleep medicine researchAmerican Thoracic Society meetingOfficial American Thoracic Society Workshop ReportCommon chronic diseasesMedicine researchNonmalignant diseasesLung cancerChronic diseasesPractice guidelinesRespiratory diseaseBest practice guidelinesSleep medicineStudy designDiseaseWorkshop reportCareReporting of resultsRelevant diseasesSingle-day workshopMonogenic diseasesGenetic epidemiologyReportReview articleSociety meetings
2018
Addressing Gender Inequality in Our Disciplines: Report from the Association of Pulmonary, Critical Care, and Sleep Division Chiefs
Thomson CC, Riekert KA, Bates CK, Jena AB, Borok Z, McCallister JW, Schnapp LM, Lama VN, Kraft M, Davis SD, Finn P, Carson SS, Beck JM, Powell CA, Tanoue LT, Kaminski N, Dixon AE. Addressing Gender Inequality in Our Disciplines: Report from the Association of Pulmonary, Critical Care, and Sleep Division Chiefs. Annals Of The American Thoracic Society 2018, 15: 1382-1390. PMID: 30153425, DOI: 10.1513/annalsats.201804-252ar.Peer-Reviewed Original Research
2017
Climate change and lung health: the challenge for a new president
Hopkinson NS, Hart N, Jenkins G, Kaminski N, Rosenfeld M, Smyth A, Wilkinson A. Climate change and lung health: the challenge for a new president. Thorax 2017, 72: 295. PMID: 28104829, DOI: 10.1136/thoraxjnl-2017-209978.Peer-Reviewed Original ResearchIdentification and validation of differentially expressed transcripts by RNA-sequencing of formalin-fixed, paraffin-embedded (FFPE) lung tissue from patients with Idiopathic Pulmonary Fibrosis
Vukmirovic M, Herazo-Maya JD, Blackmon J, Skodric-Trifunovic V, Jovanovic D, Pavlovic S, Stojsic J, Zeljkovic V, Yan X, Homer R, Stefanovic B, Kaminski N. Identification and validation of differentially expressed transcripts by RNA-sequencing of formalin-fixed, paraffin-embedded (FFPE) lung tissue from patients with Idiopathic Pulmonary Fibrosis. BMC Pulmonary Medicine 2017, 17: 15. PMID: 28081703, PMCID: PMC5228096, DOI: 10.1186/s12890-016-0356-4.Peer-Reviewed Original ResearchConceptsPaired-end sequencingTranscript profilingHuman genomeRNA sequencingTranscriptomic profilingFFPE lung tissuesSequencing readsLung tissueTotal RNABackgroundIdiopathic pulmonary fibrosisLethal lung diseaseSequencingReadsProfilingPulmonary fibrosisLung diseaseUnknown etiologyIPF tissueGenomeHiSeqTissueTopHat2GenesIPFRNA
2015
Update in Diffuse Parenchymal Lung Disease 2013
Rosas IO, Kaminski N. Update in Diffuse Parenchymal Lung Disease 2013. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 270-274. PMID: 25635490, PMCID: PMC4351573, DOI: 10.1164/rccm.201405-0856up.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Inflammatory Agents, Non-SteroidalClinical Trials, Phase III as TopicDisease ProgressionDrug ApprovalEnzyme InhibitorsGenomicsHumansIdiopathic Pulmonary FibrosisIndolesLung Diseases, InterstitialPolymorphism, GeneticPyridonesTreatment OutcomeUnited StatesUnited States Food and Drug AdministrationConceptsMajority of patientsDistinct clinical presentationsSignificant clinical implicationsClinical presentationPulmonary fibrosis researchDisease progressionClinical implicationsGenetic biomarkersPatientsFibrosis researchGenetic variantsBiological mechanismsIPFNew biological mechanismsNintedanibPirfenidonePeriodHistoric approval
2013
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study
Noth I, Zhang Y, Ma SF, Flores C, Barber M, Huang Y, Broderick SM, Wade MS, Hysi P, Scuirba J, Richards TJ, Juan-Guardela BM, Vij R, Han MK, Martinez FJ, Kossen K, Seiwert SD, Christie JD, Nicolae D, Kaminski N, Garcia J. Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. The Lancet Respiratory Medicine 2013, 1: 309-317. PMID: 24429156, PMCID: PMC3894577, DOI: 10.1016/s2213-2600(13)70045-6.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide significanceSingle nucleotide polymorphismsAssociation studiesThree-stage genome-wide association studyDiscovery Genome-Wide Association StudiesGene expression profiling dataGenetic variantsWide association studyRare genetic variantsAdditional common variantsDNA samplesMinor alleleCommon single nucleotide polymorphismsNovel variantsPulmonary Fibrosis FoundationDatabase of GenotypesGenetic lociTollip expressionNucleotide polymorphismsProfiling dataSNP genotypesCommon variantsIPF susceptibilityCommon alleles
2011
Evolving Genomic Approaches to Idiopathic Pulmonary Fibrosis: Moving Beyond Genes
Kass DJ, Kaminski N. Evolving Genomic Approaches to Idiopathic Pulmonary Fibrosis: Moving Beyond Genes. Clinical And Translational Science 2011, 4: 372-379. PMID: 22029812, PMCID: PMC3229869, DOI: 10.1111/j.1752-8062.2011.00287.x.Peer-Reviewed Original ResearchMeSH KeywordsEpigenesis, GeneticGenesGenomicsHumansIdiopathic Pulmonary FibrosisNational Institutes of Health (U.S.)United StatesConceptsGenomic technologiesIdiopathic pulmonary fibrosisPathogenesis of diseaseGenomic discoveriesSystems biology approachGene expression profilingContribution of microRNAsMost human diseasesGenomic approachesGene networksBiology approachHuman genomeEpigenetic researchGenomic dataExpression profilingHuman diseasesPulmonary fibrosisDiagnosis of IPFGenesLarge collaborative studiesProgressive scarringPeripheral bloodClinical severityLung parenchymaTherapeutic goals
2009
Impact of a disease-management program on symptom burden and health-related quality of life in patients with idiopathic pulmonary fibrosis and their care partners
Lindell KO, Olshansky E, Song MK, Zullo TG, Gibson KF, Kaminski N, Hoffman LA. Impact of a disease-management program on symptom burden and health-related quality of life in patients with idiopathic pulmonary fibrosis and their care partners. Heart & Lung 2009, 39: 304-313. PMID: 20561836, PMCID: PMC3467095, DOI: 10.1016/j.hrtlng.2009.08.005.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAgedAnalysis of VarianceAnxietyCaregiversDepressionDisease ManagementDisease ProgressionFemaleHealth Status IndicatorsHumansIdiopathic Pulmonary FibrosisMalePilot ProjectsPsychometricsQuality of LifeRespiratory Function TestsStress, PsychologicalSurveys and QuestionnairesUnited StatesConceptsDisease management interventionsAdvanced lung diseaseHealth-related qualityIdiopathic pulmonary fibrosisSymptom burdenLung diseaseCare partnersPulmonary fibrosisExperimental group participantsTime of diagnosisInterstitial lung diseaseExperimental group patientsGroup participantsPittsburgh Medical CenterDisease management programsPulmonary fibrosis resultsGroup patientsRespiratory failureUsual careMedian survivalIntervention groupPatient participantsMedical CenterFibrosis resultsPatients
2006
Lessons from Our Patients: Development of a Warm Autopsy Program
Lindell KO, Erlen JA, Kaminski N. Lessons from Our Patients: Development of a Warm Autopsy Program. PLOS Medicine 2006, 3: e234. PMID: 16724871, PMCID: PMC1472556, DOI: 10.1371/journal.pmed.0030234.Peer-Reviewed Original Research