2018
Fibrosis: Lessons from OMICS analyses of the human lung
Yu G, Ibarra GH, Kaminski N. Fibrosis: Lessons from OMICS analyses of the human lung. Matrix Biology 2018, 68: 422-434. PMID: 29567123, PMCID: PMC6015529, DOI: 10.1016/j.matbio.2018.03.014.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisDramatic phenotypic alterationsTranscriptomic studiesOmics analysisOmics profilingOmics technologiesPulmonary fibrosisNumerous aberrationsPhenotypic alterationsMechanistic understandingHuman idiopathic pulmonary fibrosisIPF lung tissueEpithelial cellsCentral roleHuman tissuesIPF samplesNew insightsMolecular featuresIPF lungsInflammatory cellsPatient cohortLung tissueAnimal modelsLethal disorderHuman lung
2005
From signatures to models: understanding cancer using microarrays
Segal E, Friedman N, Kaminski N, Regev A, Koller D. From signatures to models: understanding cancer using microarrays. Nature Genetics 2005, 37: s38-s45. PMID: 15920529, DOI: 10.1038/ng1561.Peer-Reviewed Original ResearchConceptsTranscriptional networksModel organismsRegulatory mechanismsBiological processesMolecular underpinningsMechanistic understandingModular organizationDisease mechanismsComputational analysisComprehensive viewGenomicsRobust signatureOrganismsMicroarrayComparative analysisMechanismSignaturesCellsCancerManagement of cancer