Carbon Monoxide Modulates α–Smooth Muscle Actin and Small Proline Rich-1a Expression in Fibrosis
Zheng L, Zhou Z, Lin L, Alber S, Watkins S, Kaminski N, Choi AM, Morse D. Carbon Monoxide Modulates α–Smooth Muscle Actin and Small Proline Rich-1a Expression in Fibrosis. American Journal Of Respiratory Cell And Molecular Biology 2008, 41: 85-92. PMID: 19097987, PMCID: PMC2701963, DOI: 10.1165/rcmb.2007-0401oc.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdministration, InhalationAnimalsBleomycinBone DevelopmentCarbon MonoxideCell DeathCell MovementCells, CulturedCornified Envelope Proline-Rich ProteinsDisease Models, AnimalDose-Response Relationship, DrugExtracellular Signal-Regulated MAP KinasesFibroblastsGene Expression ProfilingLungMaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLMuscle DevelopmentOrganometallic CompoundsPulmonary FibrosisTime FactorsTransforming Growth Factor beta1UbiquitinationConceptsExtracellular signal-regulated kinase (ERK) pathwayCategories of genesSignal-regulated kinase pathwayNovel transcriptional targetMuscular system developmentGene expression profilingMurine bleomycin modelStress-inducible enzymeTranscriptional targetsAlpha-smooth muscle actin expressionExpression profilingKinase pathwayMuscle actin expressionΑ-smooth muscle actinEffects of COActin expressionGrowth factorHeme oxygenaseExpressionMuscle actinActive moleculesGenesOxygenaseProteinActinMolecular Staging of Epithelial Maturation Using Secretory Cell–Specific Genes as Markers
Zemke AC, Snyder JC, Brockway BL, Drake JA, Reynolds SD, Kaminski N, Stripp BR. Molecular Staging of Epithelial Maturation Using Secretory Cell–Specific Genes as Markers. American Journal Of Respiratory Cell And Molecular Biology 2008, 40: 340-348. PMID: 18757308, PMCID: PMC2645532, DOI: 10.1165/rcmb.2007-0380oc.Peer-Reviewed Original ResearchConceptsCell-specific genesCategories of genesUnique gene expression profileDevelopmental expression patternsSecretory cellsGene expression profilesCell marker genesExpression of FMO3Messenger RNA abundanceUnique developmental expression patternTransgenic approachesClara cell markerRNA abundanceMarker genesClara cellsExpression patternsExpression profilesMolecular markersEpithelial maturationPhenotypic changesFlavin monooxygenase 3GenesTemporal inductionBronchiolar Clara cellsEmbryonic day