2023
Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity.
Li X, Guerra S, Ledford JG, Kraft M, Li H, Hastie AT, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Israel E, Jarjour NN, Levy BD, Mauger DT, Moore WC, Zein J, Kaminski N, Wenzel SE, Woodruff PG, Meyers DA, Bleecker ER. Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity. American Journal Of Respiratory And Critical Care Medicine 2023, 207: 438-451. PMID: 36066606, PMCID: PMC9940145, DOI: 10.1164/rccm.202206-1230oc.Peer-Reviewed Original ResearchConceptsBronchial epithelial cellsMRNA expression levelsAsthma severityT2 biomarkersAsthma susceptibilityT2 inflammationExpression levelsSevere Asthma Research ProgramSystemic corticosteroid useLower pulmonary functionEpithelial cellsAsthma-related phenotypesCorticosteroid useAsthma exacerbationsPulmonary functionAsthma developmentAsthma endotypesAsthma progressionInflammation biomarkersInflammation genesHost defenseCC16Th2 genesSeverityBiomarkers
2020
Summary and Future Applications of Precision Medicine in Pulmonary, Critical Care, and Sleep Medicine
Gomez J, Kaminski N, Himes B. Summary and Future Applications of Precision Medicine in Pulmonary, Critical Care, and Sleep Medicine. Respiratory Medicine 2020, 417-428. DOI: 10.1007/978-3-030-31507-8_28.Peer-Reviewed Original ResearchCritical careSleep medicinePrecision medicine strategiesNovel biomarker candidatesDisease endotypesClinical studiesDisease pathogenesisHealthcare providersNovel interventionsBiomarker candidatesMedicine strategiesPrecision medicineDrug targetsCareMolecular underpinningsWidespread implementationMedicineEndotypesPulmonaryPathogenesisCohortInitial discoveryBiomarkers
2019
LCox: a tool for selecting genes related to survival outcomes using longitudinal gene expression data
Sun J, Herazo-Maya JD, Wang JL, Kaminski N, Zhao H. LCox: a tool for selecting genes related to survival outcomes using longitudinal gene expression data. Statistical Applications In Genetics And Molecular Biology 2019, 18: 20170060. PMID: 30759070, DOI: 10.1515/sagmb-2017-0060.Peer-Reviewed Original Research
2012
Biomarkers in idiopathic pulmonary fibrosis
Zhang Y, Kaminski N. Biomarkers in idiopathic pulmonary fibrosis. Current Opinion In Pulmonary Medicine 2012, 18: 441-446. PMID: 22847105, PMCID: PMC4165635, DOI: 10.1097/mcp.0b013e328356d03c.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisPeripheral blood biomarkersPulmonary fibrosisBlood biomarkersDisease presenceMultiple clinical contextsPeripheral bloodPredictive biomarkersGene polymorphismsLarger studyDrug studiesOutcome trajectoriesPrediction ruleClinical contextBiomarkersMolecular biomarkersMultiple studiesPatientsFibrosisSufficient evidenceOutcomesProtein markersConvincing evidenceRecent studiesMarkersIdentification Of Biomarkers To Monitor The Activity Of STX-100, A Humanized Anti-±v²6 Antibody, In A Phase 2a Trial In Idiopathic Pulmonary Fibrosis
Violette S, Sheppard D, Rosas I, Arjomandi M, Rice T, Gilman M, Kaminski N, Prasse A, Maroni B. Identification Of Biomarkers To Monitor The Activity Of STX-100, A Humanized Anti-±v²6 Antibody, In A Phase 2a Trial In Idiopathic Pulmonary Fibrosis. 2012, a2659-a2659. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2659.Peer-Reviewed Original Research
2008
Malignancy in Lung Transplantation: Biomarkers, Gender Differences, and Consideration of a Systems Biology Approach
Studer SM, Taioli E, Crespo M, Kaminski N. Malignancy in Lung Transplantation: Biomarkers, Gender Differences, and Consideration of a Systems Biology Approach. Transplantation 2008, 85: s69-s71. PMID: 18425041, DOI: 10.1097/tp.0b013e31816c2feb.Peer-Reviewed Original Research
2005
Can Blood Gene Expression Predict Which Patients with Multiple Sclerosis Will Respond to Interferon?
Kaminski N, Achiron A. Can Blood Gene Expression Predict Which Patients with Multiple Sclerosis Will Respond to Interferon? PLOS Medicine 2005, 2: e33. PMID: 15736992, PMCID: PMC549584, DOI: 10.1371/journal.pmed.0020033.Peer-Reviewed Original Research