2020
Implications of Oligomeric Amyloid-Beta (oAβ42) Signaling through α7β2-Nicotinic Acetylcholine Receptors (nAChRs) on Basal Forebrain Cholinergic Neuronal Intrinsic Excitability and Cognitive Decline
George AA, Vieira JM, Xavier-Jackson C, Gee MT, Cirrito JR, Bimonte-Nelson HA, Picciotto MR, Lukas RJ, Whiteaker P. Implications of Oligomeric Amyloid-Beta (oAβ42) Signaling through α7β2-Nicotinic Acetylcholine Receptors (nAChRs) on Basal Forebrain Cholinergic Neuronal Intrinsic Excitability and Cognitive Decline. Journal Of Neuroscience 2020, 41: 555-575. PMID: 33239400, PMCID: PMC7821864, DOI: 10.1523/jneurosci.0876-20.2020.Peer-Reviewed Original ResearchMeSH KeywordsAlpha7 Nicotinic Acetylcholine ReceptorAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsBasal ForebrainCell LineCognitive DysfunctionElectrophysiological PhenomenaFemaleGenotypeHumansMaleMaze LearningMiceMice, TransgenicNeuronsParasympathetic Nervous SystemPeptide FragmentsSignal TransductionConceptsBasal forebrain cholinergic neuronsNeuronal intrinsic excitabilityAlzheimer's diseaseCholinergic neuronsDiagonal bandIntrinsic excitabilityAPP/PS1 transgenic miceCognitive declineCharacteristics of ADMedial septum-diagonal bandNicotinic acetylcholine receptor subtypesOligomeric amyloid betaAction potential firing rateForebrain cholinergic neuronsPS1 transgenic miceHorizontal diagonal bandLevels of amyloidSeptum-diagonal bandCurrent-clamp recordingsAcetylcholine receptor subtypesAction potential afterhyperpolarizationAge-matched littermatesOrganotypic slice culturesSpatial reference memoryHomomeric α7
2011
Rare Nonsynonymous Variants in Alpha-4 Nicotinic Acetylcholine Receptor Gene Protect Against Nicotine Dependence
Xie P, Kranzler HR, Krauthammer M, Cosgrove KP, Oslin D, Anton RF, Farrer LA, Picciotto MR, Krystal JH, Zhao H, Gelernter J. Rare Nonsynonymous Variants in Alpha-4 Nicotinic Acetylcholine Receptor Gene Protect Against Nicotine Dependence. Biological Psychiatry 2011, 70: 528-536. PMID: 21683344, PMCID: PMC3199609, DOI: 10.1016/j.biopsych.2011.04.017.Peer-Reviewed Original ResearchThe Galanin Receptor 1 Gene Associates with Tobacco Craving in Smokers Seeking Cessation Treatment
Lori A, Tang Y, O'Malley S, Picciotto MR, Wu R, Conneely KN, Cubells JF. The Galanin Receptor 1 Gene Associates with Tobacco Craving in Smokers Seeking Cessation Treatment. Neuropsychopharmacology 2011, 36: 1412-1420. PMID: 21430647, PMCID: PMC3096810, DOI: 10.1038/npp.2011.25.Peer-Reviewed Original ResearchMeSH KeywordsAdultComputational BiologyFemaleGenome-Wide Association StudyGenotypeHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotidePsychiatric Status Rating ScalesPsychological TestsReceptor, Galanin, Type 1Severity of Illness IndexSmoking CessationSurveys and QuestionnairesTobacco Use DisorderConceptsNicotine dependenceSingle nucleotide polymorphismsUseful therapeutic targetAddiction-related behaviorsFagerström scalePreclinical evidenceCessation treatmentPharmacological treatmentCessation trialCC subjectsTobacco cravingWithdrawal ScaleFTND scoreTC genotypeTherapeutic targetGalaninGene associatesSmokersSmokingBehavioral parametersSeverityGenetic association studiesSubjectsTreatmentScores
2008
Allelic Variation of Calsyntenin 2 (CLSTN2) Modulates the Impact of Developmental Tobacco Smoke Exposure on Mnemonic Processing in Adolescents
Jacobsen LK, Picciotto MR, Heath CJ, Mencl WE, Gelernter J. Allelic Variation of Calsyntenin 2 (CLSTN2) Modulates the Impact of Developmental Tobacco Smoke Exposure on Mnemonic Processing in Adolescents. Biological Psychiatry 2008, 65: 671-679. PMID: 19058786, PMCID: PMC2864130, DOI: 10.1016/j.biopsych.2008.10.024.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent BehaviorAdolescent DevelopmentAllelic ImbalanceBrainCalcium-Binding ProteinsFemaleGenotypeHumansIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMemory DisordersPhosphoproteinsPregnancyPrenatal Exposure Delayed EffectsProteinsTemporal LobeTobacco Smoke PollutionConceptsAdolescent exposureCalsyntenin-2Visuospatial memoryMedial temporal lobe functionRecall of wordsRecognition memory taskFunctional magnetic resonance imaging (fMRI) dataTemporal lobe functionEnhanced functional connectivityMemory taskVerbal recallMnemonic processingVerbal recognitionIndividual differencesAdolescent developmentLobe functionKIBRA genotypeDependent measuresMagnetic resonance imaging dataFunctional connectivityParahippocampal gyrusSubsequent deficitsBrain regionsMemoryAdolescents
2007
Galanin Protects Against Behavioral and Neurochemical Correlates of Opiate Reward
Hawes JJ, Brunzell DH, Narasimhaiah R, Langel Ű, Wynick D, Picciotto MR. Galanin Protects Against Behavioral and Neurochemical Correlates of Opiate Reward. Neuropsychopharmacology 2007, 33: 1864-1873. PMID: 17957220, PMCID: PMC2504505, DOI: 10.1038/sj.npp.1301579.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBlotting, WesternBrain ChemistryConditioning, OperantCyclic AMP Response Element-Binding ProteinDose-Response Relationship, DrugExtracellular Signal-Regulated MAP KinasesGalaninGenotypeMiceMice, KnockoutMorphineMorphine DependenceMotor ActivityNarcoticsRewardSignal TransductionConceptsGKO miceMorphine place preferenceOpiate rewardGalanin agonistsMorphine administrationPlace preferenceGalanin knockout miceSingle systemic injectionEndogenous negative regulatorDrugs of abuseAcute administrationNeurochemical effectsNeuropeptide galaninPeripheral injectionWithdrawal signsLocomotor activationSystemic injectionNeurochemical correlatesNucleus accumbensGalaninKnockout miceTherapeutic targetBrain areasDrug reinforcementGalnon
2000
Nicotinic-agonist stimulated 86Rb+ efflux and [3H]epibatidine binding of mice differing in β2 genotype
Marks M, Stitzel J, Grady S, Picciotto M, Changeux J, Collins A. Nicotinic-agonist stimulated 86Rb+ efflux and [3H]epibatidine binding of mice differing in β2 genotype. Neuropharmacology 2000, 39: 2632-2645. PMID: 11044733, DOI: 10.1016/s0028-3908(00)00115-5.Peer-Reviewed Original ResearchConceptsBrain regionsNicotinic acetylcholine receptor functionBeta2 subunitBeta2-containing receptorsAcetylcholine receptor functionHigh-affinity siteBeta2 subunit expressionBinding of mouseCerebral cortexNicotinic responsesMicroM nicotineOlfactory bulbInferior colliculusNicotinic agonistsSubunit expressionReceptor functionLow affinityLow affinity sitesDHbetaEInhibitionMiceStimulationEffluxCytisineNull mutationPharmacological and null mutation approaches reveal nicotinic receptor diversity
Whiteaker P, Marks M, Grady S, Lu Y, Picciotto M, Changeux J, Collins A. Pharmacological and null mutation approaches reveal nicotinic receptor diversity. European Journal Of Pharmacology 2000, 393: 123-135. PMID: 10771005, DOI: 10.1016/s0014-2999(00)00052-2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNicotinic acetylcholine receptor functionNicotinic acetylcholine receptorsAcetylcholine receptor functionAcetylcholine receptorsNicotinic acetylcholine receptor bindingReceptor functionNative nicotinic acetylcholine receptorsNicotinic acetylcholine receptor subtypesWhole brain preparationAcetylcholine receptor bindingAcetylcholine receptor subtypesMouse brain membranesArray of assaysReceptor subtypesPharmacological comparisonComparative pharmacologyBrain nucleiBrain membranesEfflux techniqueReceptor bindingSubunit deletionReceptor diversityReceptorsAminobutyric acidSubtypes