2016
Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism
Fan L, Balakrishna S, Jabba SV, Bonner PE, Taylor SR, Picciotto MR, Jordt SE. Menthol decreases oral nicotine aversion in C57BL/6 mice through a TRPM8-dependent mechanism. Tobacco Control 2016, 25: ii50. PMID: 27698211, PMCID: PMC5496986, DOI: 10.1136/tobaccocontrol-2016-053209.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDose-Response Relationship, DrugMaleMentholMiceMice, Inbred C57BLMice, KnockoutNicotineNicotinic AgonistsTobacco, SmokelessTRPM Cation ChannelsConceptsSmokeless tobacco productsWild-type miceOral nicotineC57BL/6 miceTobacco productsNicotine aversionAversive effectsTwo-bottle choice drinkingTrigeminal sensory neuronsEffect of mentholProduct useMenthol concentrationOral mentholSensory neuronsAversive concentrationsMenthol receptorOral cavityMenthol effectsRespiratory irritationMiceNicotineTRPM8Oral irritantsIrritantsAversive taste
2013
Differential Modulation of Brain Nicotinic Acetylcholine Receptor Function by Cytisine, Varenicline, and Two Novel Bispidine Compounds: Emergent Properties of a Hybrid Molecule
Peng C, Stokes C, Mineur YS, Picciotto MR, Tian C, Eibl C, Tomassoli I, Guendisch D, Papke RL. Differential Modulation of Brain Nicotinic Acetylcholine Receptor Function by Cytisine, Varenicline, and Two Novel Bispidine Compounds: Emergent Properties of a Hybrid Molecule. Journal Of Pharmacology And Experimental Therapeutics 2013, 347: 424-437. PMID: 23959137, PMCID: PMC3807070, DOI: 10.1124/jpet.113.206904.Peer-Reviewed Original ResearchMeSH KeywordsAlkaloidsAnimalsAzocinesBehavior, AnimalBenzazepinesBrainBridged Bicyclo Compounds, HeterocyclicDose-Response Relationship, DrugDrug Partial AgonismHEK293 CellsHumansMaleMembrane PotentialsMiceMolecular StructureNicotinic AgonistsOocytesPatch-Clamp TechniquesQuinolizinesQuinoxalinesRatsRats, Sprague-DawleyReceptors, NicotinicTobacco Use DisorderVareniclineXenopus laevisConceptsPartial agonistLGN neuronsMouse tail suspension testLateral geniculate nucleus neuronsNicotinic acetylcholine receptor functionPartial agonist therapiesTail suspension testStratum radiatum interneuronsSmoking cessation drugNicotinic partial agonistAcetylcholine receptor functionHuman embryonic kidney 293 cellsSteady-state activationAgonist therapyRadiatum interneuronsEmbryonic kidney 293 cellsCessation drugsNucleus neuronsSuspension testΑ7 currentsNicotine addictionSide effectsVareniclineΑ4β2 nAChRsSR interneurons
2012
Nicotine-taking and nicotine-seeking in C57Bl/6J mice without prior operant training or food restriction
Yan Y, Pushparaj A, Gamaleddin I, Steiner RC, Picciotto MR, Roder J, Le Foll B. Nicotine-taking and nicotine-seeking in C57Bl/6J mice without prior operant training or food restriction. Behavioural Brain Research 2012, 230: 34-39. PMID: 22326373, PMCID: PMC3310267, DOI: 10.1016/j.bbr.2012.01.042.Peer-Reviewed Original ResearchConceptsNose-poke behaviorPrior operant trainingFood restrictionDose-response curveNicotine-seeking behaviorC57BL/6J miceIntermittent footshockFlat dose-response curveNaive C57BL/6J miceInjections of nicotineOperant trainingNicotine self-administration paradigmSelf-administration paradigmCue presentationSelf-administered salineNicotine groupNicotine reinforcementLight cue presentationPriming injectionsFR2 scheduleSecond consecutive dayConsecutive daysMiceDaily sessionsNicotine
2011
Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380
Caldarone BJ, Wang D, Paterson NE, Manzano M, Fedolak A, Cavino K, Kwan M, Hanania T, Chellappan SK, Kozikowski AP, Olivier B, Picciotto MR, Ghavami A. Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380. Psychopharmacology 2011, 217: 199-210. PMID: 21487659, PMCID: PMC3266849, DOI: 10.1007/s00213-011-2271-y.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntidepressive AgentsAzetidinesBehavior, AnimalBenzazepinesBrainData Interpretation, StatisticalDose-Response Relationship, DrugLigandsMaleMiceMice, Inbred BALB CMice, Inbred C57BLMolecular StructureMotor ActivityNicotinic AgonistsProtein BindingPyridinesQuinoxalinesReceptors, NicotinicSwimmingTime FactorsVareniclineConceptsAntidepressant-like effectsAntidepressant-like actionSwim testDuration of actionReceptor occupancyNAChR antagonist mecamylamineDihydro-β-erythroidineAcetylcholine receptor agonistRole of β2Partial agonist vareniclineSymptoms of depressionNAChR β2Antagonist mecamylamineReceptor agonistActive dosesAgonist vareniclineSazetidinePartial agonistVareniclineObjectivesThe studyBehavioral efficacyNAChRsBehavioral responsesAgonistsPromising target
2010
Locomotion and Self-Administration Induced by Cocaine in 129/OlaHsd Mice Lacking Galanin
Brabant C, Kuschpel AS, Picciotto MR. Locomotion and Self-Administration Induced by Cocaine in 129/OlaHsd Mice Lacking Galanin. Behavioral Neuroscience 2010, 124: 828-838. PMID: 21038934, PMCID: PMC3058554, DOI: 10.1037/a0021221.Peer-Reviewed Original ResearchConceptsGal KO miceCocaine-induced hyperactivityGalanin receptor agonistCocaine-induced hyperlocomotionSpontaneous motor activityGalanin knockout miceEffects of cocaineDrug takersDoses of cocaineDrugs of abuseSelf-administer cocaineGalanin systemReceptor agonistLocomotor effectsKnockout miceGalaninIntravenous cocaineMotor activityFixed ratio scheduleSelf-AdministrationGenetic deletionMiceCocaineDifferent schedulesRatio scheduleModulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice
Kamens HM, Andersen J, Picciotto MR. Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice. Psychopharmacology 2010, 208: 613-626. PMID: 20072781, PMCID: PMC2901400, DOI: 10.1007/s00213-009-1759-1.Peer-Reviewed Original ResearchConceptsEffects of vareniclineEthanol consumptionNicotinic acetylcholine receptorsEthanol intakeAcetylcholine receptorsPharmacological manipulationΒ2 subunitRole of nAChRsTwo-bottle choice paradigmWild-type micePartial agonist vareniclineSubunit knockout miceMesolimbic dopamine systemNicotinic controlVarenicline doseAlcohol drinkingAgonist vareniclineKnockout miceDopamine systemNicotine responseChallenge studiesVareniclineNAChRsReceptor subunitsMice
2009
The membrane cytoskeletal protein adducin is phosphorylated by protein kinase C in D1 neurons of the nucleus accumbens and dorsal striatum following cocaine administration
Lavaur J, Mineur YS, Picciotto MR. The membrane cytoskeletal protein adducin is phosphorylated by protein kinase C in D1 neurons of the nucleus accumbens and dorsal striatum following cocaine administration. Journal Of Neurochemistry 2009, 111: 1129-1137. PMID: 19780900, PMCID: PMC2810345, DOI: 10.1111/j.1471-4159.2009.06405.x.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBenzazepinesBenzophenanthridinesCalmodulin-Binding ProteinsCocaineCorpus StriatumDopamine AntagonistsDopamine Uptake InhibitorsDose-Response Relationship, DrugEnzyme InhibitorsGene Expression RegulationGreen Fluorescent ProteinsMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsNucleus AccumbensPhosphorylationProtein Kinase CRacloprideReceptors, Dopamine D1Time FactorsConceptsProtein kinase CAdducin phosphorylationKinase CActin-binding proteinsFamily of proteinsPhosphorylation of adducinCytoskeletal protein adducinActin dynamicsCytoskeletal rearrangementsPhosphorylation stateCytoskeletal proteinsAdducinF-actinPhosphorylationNeuronal cytoskeletonCellular architectureProteinSynaptic functionMorphological changesCytoskeletonMedium spiny neuronsSpectrinRegimen of cocaineActinRegulationNucleus Accumbens CREB Activity is Necessary for Nicotine Conditioned Place Preference
Brunzell DH, Mineur YS, Neve RL, Picciotto MR. Nucleus Accumbens CREB Activity is Necessary for Nicotine Conditioned Place Preference. Neuropsychopharmacology 2009, 34: 1993-2001. PMID: 19212318, PMCID: PMC2709692, DOI: 10.1038/npp.2009.11.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsConditioning, PsychologicalCuesCyclic AMP Response Element-Binding ProteinDecision MakingDose-Response Relationship, DrugDown-RegulationGene Transfer TechniquesMaleMiceMice, Inbred C57BLNicotineNicotinic AgonistsNucleus AccumbensPhosphorylationRewardSynaptic TransmissionTobacco Use DisorderUp-RegulationConceptsCyclic AMP response element binding proteinNAc shellPlace preferenceNicotine CPPCREB activityModulation of cocaineCREB activationNicotine place preferenceAbility of nicotineAbsence of nicotineCue-induced responsesDominant-negative CREB constructNicotinic acetylcholine receptorsAMP response element binding proteinLevels of CREBTranscription factor cyclic AMP response element binding proteinViral-mediated gene transferRange of dosesActivation of intracellularNicotine exposureMorphine rewardC57BL/6J miceNicotine rewardDopamine neuronsLong-term consequencesVarenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect
Rollema H, Guanowsky V, Mineur YS, Shrikhande A, Coe JW, Seymour PA, Picciotto MR. Varenicline has antidepressant-like activity in the forced swim test and augments sertraline's effect. European Journal Of Pharmacology 2009, 605: 114-116. PMID: 19168054, PMCID: PMC2707785, DOI: 10.1016/j.ejphar.2009.01.002.Peer-Reviewed Original ResearchConceptsAntidepressant-like activitySwim testPartial agonistNicotinic acetylcholine receptor activityNicotinic acetylcholine receptor partial agonistSelective serotonin reuptake inhibitor sertralineSerotonin reuptake inhibitor sertralineSelective serotonin reuptake inhibitorsAntidepressant-like propertiesAcetylcholine receptor activitySerotonin reuptake inhibitorsSmoking cessation aidReceptor partial agonistSertraline effectsVarenicline doseAntidepressant responseReuptake inhibitorsAntidepressant potentialCessation aidActive dosesAcetylcholine receptorsReceptor activityVareniclineMouse strainsAgonists
2008
Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice
Narasimhaiah R, Kamens HM, Picciotto MR. Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice. Psychopharmacology 2008, 204: 95-102. PMID: 19099295, PMCID: PMC2872184, DOI: 10.1007/s00213-008-1438-7.Peer-Reviewed Original ResearchConceptsVentral tegmental areaEffects of galaninNucleus accumbensNeuropeptide galaninPlace preferenceThreshold doseEffects of morphineMesolimbic dopamine systemMesolimbic dopaminergic pathwaySystemic cocaine injectionPlace preference paradigmCocaine-induced activationDrugs of abuseAmphetamine reinforcementWild-type controlsExtracellular signal-regulated kinase (ERK) activityTegmental areaCocaine injectionCocaine responseDopaminergic pathwaysConclusionsThese dataGalaninRewarding effectsDopamine systemDrug reinforcementEffects of the H3 receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions
Brabant C, Alleva L, Grisar T, Quertemont E, Lakaye B, Ohtsu H, Lin JS, Jatlow P, Picciotto MR, Tirelli E. Effects of the H3 receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions. Psychopharmacology 2008, 202: 673-687. PMID: 18843481, DOI: 10.1007/s00213-008-1345-y.Peer-Reviewed Original ResearchConceptsEffects of thioperamideCocaine-induced hyperlocomotionCocaine-induced locomotionLocomotor effectsHistaminergic systemKnockout micePotential drug-drug interactionsContribution of histamineNon-histaminergic neuronsPlasma cocaine concentrationsPotential pharmacokinetic interactionsCocaine-induced hyperactivityCocaine plasma concentrationsDrug-drug interactionsReceptor inverse agonistInverse agonist thioperamideSelective H3 agonistH3 receptor inverse agonistConclusionsThe present resultsH3 autoreceptorsPharmacokinetic interactionsIntraperitoneal injectionAgonist AHistamine releasePharmacokinetic effectsRegulation of Synaptic Efficacy in Hypocretin/Orexin-Containing Neurons by Melanin Concentrating Hormone in the Lateral Hypothalamus
Rao Y, Lu M, Ge F, Marsh DJ, Qian S, Wang AH, Picciotto MR, Gao XB. Regulation of Synaptic Efficacy in Hypocretin/Orexin-Containing Neurons by Melanin Concentrating Hormone in the Lateral Hypothalamus. Journal Of Neuroscience 2008, 28: 9101-9110. PMID: 18784290, PMCID: PMC2562258, DOI: 10.1523/jneurosci.1766-08.2008.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnalysis of VarianceAnimalsAnimals, NewbornBehavior, AnimalBenzazepinesBenzhydryl CompoundsCentral Nervous System StimulantsDopamine AgonistsDose-Response Relationship, DrugExcitatory Amino Acid AgentsGlutamic AcidGreen Fluorescent ProteinsHypothalamic Area, LateralHypothalamic HormonesIn Vitro TechniquesIntracellular Signaling Peptides and ProteinsMelaninsMiceMice, Inbred C57BLMice, TransgenicModafinilMotor ActivityNeuronsNeuropeptidesOrexinsPertussis ToxinPituitary HormonesReceptors, SomatostatinSynapsesSynaptic TransmissionTime FactorsConceptsHypocretin/orexin neuronsMCHR1 KO miceOrexin-containing neuronsLateral hypothalamusWild-type miceOrexin neuronsHypocretin/orexinKO miceMCH receptor 1Action potential firingEffects of modafinilMelanin-Concentrating HormoneHypocretin/orexin signalingGroups of neuronsMCH neuronsMiniature EPSCsWT miceHypocretin/Glutamatergic synapsesOrexin signalingSynaptic transmissionPertussis toxinBrain areasReciprocal innervationInhibitory influenceSex differences in anxiety-like behavior and locomotor activity following chronic nicotine exposure in mice
Caldarone BJ, King SL, Picciotto MR. Sex differences in anxiety-like behavior and locomotor activity following chronic nicotine exposure in mice. Neuroscience Letters 2008, 439: 187-191. PMID: 18524488, PMCID: PMC2491450, DOI: 10.1016/j.neulet.2008.05.023.Peer-Reviewed Original ResearchConceptsAnxiogenic-like responseChronic nicotineAnxiety-like behaviorLocomotor activationFemale miceLocomotor activityPsychostimulant propertiesChronic nicotine exposureFemale C57BL/6J miceSymptoms of anxietyNicotine variesNicotine exposureOverall incidenceC57BL/6J miceMale miceWildtype miceNicotine intakeNicotinic receptorsOpen armsHigh doseMiceNicotineAnxiety disordersBeta2 subunitBehavioral sensitivity
2007
Galanin Protects Against Behavioral and Neurochemical Correlates of Opiate Reward
Hawes JJ, Brunzell DH, Narasimhaiah R, Langel Ű, Wynick D, Picciotto MR. Galanin Protects Against Behavioral and Neurochemical Correlates of Opiate Reward. Neuropsychopharmacology 2007, 33: 1864-1873. PMID: 17957220, PMCID: PMC2504505, DOI: 10.1038/sj.npp.1301579.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalBlotting, WesternBrain ChemistryConditioning, OperantCyclic AMP Response Element-Binding ProteinDose-Response Relationship, DrugExtracellular Signal-Regulated MAP KinasesGalaninGenotypeMiceMice, KnockoutMorphineMorphine DependenceMotor ActivityNarcoticsRewardSignal TransductionConceptsGKO miceMorphine place preferenceOpiate rewardGalanin agonistsMorphine administrationPlace preferenceGalanin knockout miceSingle systemic injectionEndogenous negative regulatorDrugs of abuseAcute administrationNeurochemical effectsNeuropeptide galaninPeripheral injectionWithdrawal signsLocomotor activationSystemic injectionNeurochemical correlatesNucleus accumbensGalaninKnockout miceTherapeutic targetBrain areasDrug reinforcementGalnonNicotine‐induced phosphorylation of ERK in mouse primary cortical neurons: evidence for involvement of glutamatergic signaling and CaMKII
Steiner RC, Heath CJ, Picciotto MR. Nicotine‐induced phosphorylation of ERK in mouse primary cortical neurons: evidence for involvement of glutamatergic signaling and CaMKII. Journal Of Neurochemistry 2007, 103: 666-678. PMID: 17666046, DOI: 10.1111/j.1471-4159.2007.04799.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCalcium-Calmodulin-Dependent Protein Kinase Type 2Cells, CulturedCerebral CortexCulture MediaDose-Response Relationship, DrugExtracellular Signal-Regulated MAP KinasesFemaleGlutamic AcidIndicators and ReagentsMiceMice, Inbred C57BLMice, KnockoutNeuronsNicotineNicotinic AgonistsPhosphorylationPregnancyReceptors, GlutamateReceptors, NicotinicReverse Transcriptase Polymerase Chain ReactionSignal TransductionSynaptic TransmissionConceptsNicotine-induced ERK phosphorylationExtracellular signal-regulated kinaseERK phosphorylationCAMP-dependent protein kinaseCalmodulin-dependent protein kinase IICalcium/calmodulin-dependent protein kinase IINicotinic acetylcholine receptor inhibitorNicotine-induced phosphorylationSignal-regulated kinaseCortical neuronsProtein kinase IIProtein kinase CMouse primary cortical neuronsKinase II activityAlpha3/beta4Calmodulin-dependent protein kinase II activityGlutamatergic signalingProtein kinaseVoltage-gated sodium channelsKinase IICultured mouse cortical neuronsKinase CCalcium/calmodulin-dependent protein kinase II activityPhosphorylationL-type voltage-gated calcium channels
2006
Guidelines on nicotine dose selection for in vivo research
Matta SG, Balfour DJ, Benowitz NL, Boyd RT, Buccafusco JJ, Caggiula AR, Craig CR, Collins AC, Damaj MI, Donny EC, Gardiner PS, Grady SR, Heberlein U, Leonard SS, Levin ED, Lukas RJ, Markou A, Marks MJ, McCallum SE, Parameswaran N, Perkins KA, Picciotto MR, Quik M, Rose JE, Rothenfluh A, Schafer WR, Stolerman IP, Tyndale RF, Wehner JM, Zirger JM. Guidelines on nicotine dose selection for in vivo research. Psychopharmacology 2006, 190: 269-319. PMID: 16896961, DOI: 10.1007/s00213-006-0441-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavioral ResearchDose-Response Relationship, DrugGanglionic StimulantsGuidelines as TopicHumansModels, BiologicalNicotineSpecies SpecificityConceptsRoute of administrationDose selectionAnimal modelsDose rangeNicotine replacement therapyChronic nicotine exposureDose-response relationshipDrug-taking behaviorTobacco exposureNicotine exposureCigarette smokingReplacement therapyVivo effectsChronic exposureNicotine metabolismVivo responseNonhuman primatesVivo studiesObjectivesThis reviewRegimenVivo researchAdministrationExposureGenetic backgroundReviewGalanin and galanin‐like peptide modulate neurite outgrowth via protein kinase C‐mediated activation of extracellular signal‐related kinase
Hawes JJ, Narasimhaiah R, Picciotto MR. Galanin and galanin‐like peptide modulate neurite outgrowth via protein kinase C‐mediated activation of extracellular signal‐related kinase. European Journal Of Neuroscience 2006, 23: 2937-2946. PMID: 16819983, DOI: 10.1111/j.1460-9568.2006.04828.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell DifferentiationCells, CulturedDose-Response Relationship, DrugDrug InteractionsEmbryo, MammalianEnzyme ActivationEnzyme InhibitorsExtracellular Signal-Regulated MAP KinasesGalaninGalanin-Like PeptideNeuritesNeuronsProtein Kinase CRatsReceptors, GalaninReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStem CellsConceptsGalanin-like peptideProtein kinase CNervous systemNeurite outgrowthAdult hippocampal progenitor cellsAbility of galaninKinase CERK phosphorylationHippocampal progenitor cellsNeuronal cell line PC12Central nervous systemModulates Neurite OutgrowthExtracellular signal-related kinase (ERK) phosphorylationConcentration-dependent mannerNerve injuryNeuropeptide galaninNeurotrophic effectsExtracellular signal-related kinaseReceptor subtypesNovel physiological roleAdult brainGalaninCell line PC12Signal-related kinaseProgenitor cells
2004
High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation
Caldarone BJ, Harrist A, Cleary MA, Beech RD, King SL, Picciotto MR. High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation. Biological Psychiatry 2004, 56: 657-664. PMID: 15522249, DOI: 10.1016/j.biopsych.2004.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAmitriptylineAnalysis of VarianceAnimalsAntidepressive Agents, TricyclicBehavior, AnimalBromodeoxyuridineCell CountCell ProliferationDose-Response Relationship, DrugDrosophila ProteinsDrug InteractionsHelplessness, LearnedHindlimb SuspensionHippocampusImmunohistochemistryMecamylamineMiceMice, Inbred C57BLMice, KnockoutNeuronsNicotinic AntagonistsNortriptylineReceptors, NicotinicSwimmingConceptsHigh-affinity nAChRsHippocampal cell proliferationNicotinic acetylcholine receptorsSwim testAcetylcholine receptorsCell proliferationHigh-affinity nicotinic acetylcholine receptorsNoncompetitive nAChR antagonist mecamylamineAntagonism of nAChRsAntidepressant-induced increasesAntidepressant-like effectsNAChR antagonist mecamylamineWild-type miceInhibition of nAChRsAntidepressants actAntidepressant actionAntidepressant effectsChronic treatmentAntagonist mecamylamineAntidepressant propertiesTricyclic antidepressantsAntidepressant activityTherapeutic effectKnockout miceNoncompetitive antagonist
2003
α4β2* Nicotinic Acetylcholine Receptors Modulate the Effects of Ethanol and Nicotine on the Acoustic Startle Response
Owens JC, Balogh SA, McClure‐Begley T, Butt CM, Labarca C, Lester HA, Picciotto MR, Wehner JM, Collins AC. α4β2* Nicotinic Acetylcholine Receptors Modulate the Effects of Ethanol and Nicotine on the Acoustic Startle Response. Alcohol Clinical And Experimental Research 2003, 27: 1867-1875. PMID: 14691373, DOI: 10.1097/01.alc.0000102700.72447.0f.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAnimalsDose-Response Relationship, DrugEthanolFemaleMaleMiceMice, Mutant StrainsMice, TransgenicNicotinePolymorphism, GeneticProtein SubunitsReceptors, NicotinicReflex, StartleConceptsAcoustic startle responseEffects of ethanolLSxSS RIStartle responseAcoustic startleAlpha4beta2 nAChRsEthanol effectsBeta2 null mutant miceNeuronal nicotinic cholinergic receptorsEthanol-induced depressionNicotinic cholinergic receptorsPotential roleNicotinic acetylcholine receptorsNull mutant miceAlpha4 nAChRsCholinergic receptorsTobacco abuseNicotine effectsT polymorphismAcetylcholine receptorsLSXSS recombinantMutant miceBehavioral effectsNicotineStartle
2002
Characterization of [125I]epibatidine binding and nicotinic agonist‐mediated 86Rb+ efflux in interpeduncular nucleus and inferior colliculus of β2 null mutant mice
Marks MJ, Whiteaker P, Grady SR, Picciotto MR, McIntosh JM, Collins AC. Characterization of [125I]epibatidine binding and nicotinic agonist‐mediated 86Rb+ efflux in interpeduncular nucleus and inferior colliculus of β2 null mutant mice. Journal Of Neurochemistry 2002, 81: 1102-1115. PMID: 12065623, DOI: 10.1046/j.1471-4159.2002.00910.x.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAlkaloidsAnimalsAzocinesBinding, CompetitiveBridged Bicyclo Compounds, HeterocyclicDose-Response Relationship, DrugInferior ColliculiIodine RadioisotopesMesencephalonMiceMice, Mutant StrainsNicotinic AgonistsNicotinic AntagonistsPyridinesQuinolizinesReceptors, NicotinicRubidium RadioisotopesTritiumConceptsInterpeduncular nucleusInferior colliculusBrain regionsAccessory olfactory nucleusNull mutant miceOlfactory nucleusNicotinic antagonistsD-tubocurarineMedial habenulaSelective antagonistNicotinic agonistsSuperior colliculusMouse brainAgonistsColliculusMutant micePotent agonistSimilar potencyAntagonistNicotinic activityEfflux