2002
Neuronal Systems Underlying Behaviors Related to Nicotine Addiction: Neural Circuits and Molecular Genetics
Picciotto MR, Corrigall WA. Neuronal Systems Underlying Behaviors Related to Nicotine Addiction: Neural Circuits and Molecular Genetics. Journal Of Neuroscience 2002, 22: 3338-3341. PMID: 11978809, PMCID: PMC6758396, DOI: 10.1523/jneurosci.22-09-03338.2002.Peer-Reviewed Original ResearchConceptsAction of nicotineNicotine addictionNicotinic acetylcholine receptor subunitsAcetylcholine receptor subunitsStudies of miceSerotonergic nucleiNicotine effectsDopaminergic activityDopaminergic systemNicotine dependenceBrainstem cholinergicNeural circuitsNeuronal systemsReceptor subunitsBehavioral effectsNicotineAddictionRecent studiesNeural systemsInitial observationsCholinergicGABAergicMolecular geneticsMice
1999
Use of knock-out mice to determine the molecular basis for the actions of nicotine
Picciotto M, Zoli M, Changeux J. Use of knock-out mice to determine the molecular basis for the actions of nicotine. Nicotine & Tobacco Research 1999, 1: s121-s125. PMID: 11768168, DOI: 10.1080/14622299050011931.Peer-Reviewed Original ResearchConceptsElectrophysiological propertiesBehavioral effectsSubunit combinationsAction of nicotineDifferent neurotransmitter systemsEffects of nicotineMesolimbic dopamine systemIndividual receptor subtypesNicotinic acetylcholine receptorsBinding of nicotinePossible subunit combinationsDifferent subunit combinationsNicotine effectsNicotine receptorsNicotine reinforcementReceptor subtypesDopamine levelsNeurotransmitter systemsDopamine systemNicotinic subunitsAcetylcholine receptorsAddictive propertiesNicotineMiceBeta2 subunit
1998
Nicotine Addiction: From Molecules to Behavior
Picciotto M. Nicotine Addiction: From Molecules to Behavior. The Neuroscientist 1998, 4: 391-394. DOI: 10.1177/107385849800400610.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNicotine addictionAction of nicotineNicotinic acetylcholine receptorsBinding of nicotineDrugs of abuseUnique molecular targetNicotine dependenceNovel treatmentsAcetylcholine receptorsDopamine physiologyMolecular targetsCommon pathwayNicotineBrainSite of interventionNeurobiological processesBiochemical targetsAddictionDrugsPathwaySmokingMiceReceptors