1994
The minK potassium channel exists in functional and nonfunctional forms when expressed in the plasma membrane of Xenopus oocytes
Blumenthal E, Kaczmarek L. The minK potassium channel exists in functional and nonfunctional forms when expressed in the plasma membrane of Xenopus oocytes. Journal Of Neuroscience 1994, 14: 3097-3105. PMID: 7514215, PMCID: PMC6577436, DOI: 10.1523/jneurosci.14-05-03097.1994.Peer-Reviewed Original ResearchConceptsN-terminal domainMinK proteinPlasma membraneInjected mRNAXenopus oocytesMinK potassium channelsFunctional potassium channelsPotassium channelsAmino acid epitopeProtein sequencesLevels of proteinMink genesLive oocytesIntracellular cAMP levelsKinetics of activationProteinOocytesMinK mRNANonfunctional formMRNASurface expressionRNAMinK currentsMRNA levelsCAMP levels
1988
Inositol trisphosphate releases intracellularly stored calcium and modulates ion channels in molluscan neurons
Fink L, Connor J, Kaczmarek L. Inositol trisphosphate releases intracellularly stored calcium and modulates ion channels in molluscan neurons. Journal Of Neuroscience 1988, 8: 2544-2555. PMID: 2470874, PMCID: PMC6569530, DOI: 10.1523/jneurosci.08-07-02544.1988.Peer-Reviewed Original ResearchConceptsBag cell neuronsCell neuronsIntracellular calciumAction potentialsFluorescent calcium indicator fura-2Inositol trisphosphateCalcium indicator fura-2Intracellular calcium levelsIndicator fura-2Non-neuronal cellsCell-attached patch-clamp techniquePatch-clamp techniqueMicroinjection of inositolCultured bag cell neuronsHydrolysis of phosphoinositidesCalcium-containing mediumElectrophysiological effectsInjection of inositolFura-2Calcium levelsExtracellular calciumIsolated neuronsMolluscan neuronsCytosolic calciumTransient hyperpolarization
1987
Xenopus Oocytes Injected with Rat Uterine RNA Express Very Slowly Activating Potassium Currents
Boyle M, Azhderian E, MacLusky N, Naftolin F, Kaczmarek L. Xenopus Oocytes Injected with Rat Uterine RNA Express Very Slowly Activating Potassium Currents. Science 1987, 235: 1221-1224. PMID: 2434999, DOI: 10.1126/science.2434999.Peer-Reviewed Original ResearchConceptsUterine smooth muscleSmooth musclePotassium currentAction potentialsVoltage-dependent potassium currentsInfluence of estrogenUteri of estrogenXenopus Oocytes InjectedOvariectomized ratsRat brainProlonged burstsEstrogenRepetitive burstsNegative membrane potentialsInjected oocytesRatsExcitable tissuesMuscleXenopus oocytesMembrane potentialOocytesDepolarizationMyometriumUterusBrain