1996
Inhibition by Nystatin of Kv1.3 Channels Expressed in Chinese Hamster Ovary Cells
HAHN S, WANG L, KACZMAREK L. Inhibition by Nystatin of Kv1.3 Channels Expressed in Chinese Hamster Ovary Cells. Neuropharmacology 1996, 35: 895-901. PMID: 8938720, DOI: 10.1016/0028-3908(96)00094-9.Peer-Reviewed Original ResearchConceptsKv1.3 currentsEffect of nystatinPerforated patch recordingsChinese hamster ovary cellsPatch-clamp techniqueWhole-cell configurationConcentration-dependent reductionHamster ovary cellsRectifier potassium channelHalf-maximal inhibitionPotassium channel Kv1.3Patch recordingsMaximal inhibitionAmphotericin BOvary cellsKv1.3 channelsPotassium channelsTetraethylammoniumChannel Kv1.3Intracellular solutionInhibitionRapid blockNystatinDrugsApparent inactivation
1995
Elimination of potassium channel expression by antisense oligonucleotides in a pituitary cell line.
Chung S, Saal D, Kaczmarek L. Elimination of potassium channel expression by antisense oligonucleotides in a pituitary cell line. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 5955-5959. PMID: 7597060, PMCID: PMC41620, DOI: 10.1073/pnas.92.13.5955.Peer-Reviewed Original ResearchAnimalsBase SequenceCell MembraneClone CellsDexamethasoneEgtazic AcidGene ExpressionKv1.4 Potassium ChannelKv1.5 Potassium ChannelMembrane PotentialsMolecular Sequence DataOligonucleotides, AntisensePatch-Clamp TechniquesPituitary GlandPotassium Channel BlockersPotassium ChannelsPotassium Channels, Voltage-GatedRatsRNA, MessengerTetraethylammoniumTetraethylammonium CompoundsThionucleotides
1994
A shab potassium channel contributes to action potential broadening in peptidergic neurons
Quattrocki E, Marshall J, Kaczmarek L. A shab potassium channel contributes to action potential broadening in peptidergic neurons. Neuron 1994, 12: 73-86. PMID: 8292361, DOI: 10.1016/0896-6273(94)90153-8.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAmino Acid SequenceAnimalsAplysiaBase SequenceCloning, MolecularDNA, ComplementaryFemaleInvertebrate HormonesKineticsMathematicsModels, TheoreticalMolecular Sequence DataNeuronsOocytesPolymerase Chain ReactionPotassiumPotassium ChannelsShab Potassium ChannelsTetraethylammoniumTetraethylammonium CompoundsTranscription, GeneticXenopus laevis
1984
A voltage-clamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia
Kaczmarek L, Strumwasser F. A voltage-clamp analysis of currents underlying cyclic AMP-induced membrane modulation in isolated peptidergic neurons of Aplysia. Journal Of Neurophysiology 1984, 52: 340-349. PMID: 6090605, DOI: 10.1152/jn.1984.52.2.340.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAplysiaCalciumCell MembraneCells, CulturedCyclic AMPElectric ConductivityGangliaIon ChannelsMembrane PotentialsPotassiumTetraethylammoniumTetraethylammonium CompoundsConceptsBag cell neuronsCell neuronsCyclic AMP analoguePotassium currentOutward currentsNormal ionic mediumOnset of afterdischargePhosphodiesterase-resistant cAMP analoguePeak inward currentsAMP analogueBag cell clustersDelayed potassium currentMinority of cellsSpontaneous dischargeCalcium currentPeptidergic neuronsVoltage-clamp analysisCell culturesTwo-electrode voltage clampInward currentsSodium currentNegative slope resistanceA-currentMarked reductionNeurons
1982
An early sodium and a late calcium phase in the afterdischarge of peptide-secreting neurons ofAplysia
Kaczmarek L, Jennings K, Strumwasser F. An early sodium and a late calcium phase in the afterdischarge of peptide-secreting neurons ofAplysia. Brain Research 1982, 238: 105-115. PMID: 6282390, DOI: 10.1016/0006-8993(82)90774-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAplysiaCalciumElectric StimulationGangliaIon ChannelsMembrane PotentialsNeuronsSodiumSynaptic TransmissionTetraethylammonium Compounds
1981
Serotonergic inhibition of afterdischarge in peptidergic bag cells
Jennings K, Host J, Kaczmarek L, Strumwasser F. Serotonergic inhibition of afterdischarge in peptidergic bag cells. Developmental Neurobiology 1981, 12: 579-590. PMID: 7310396, DOI: 10.1002/neu.480120606.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAplysiaElectric StimulationFemaleGangliaNeuronsOvipositionSerotoninSynapsesTetraethylammonium CompoundsConceptsEgg-laying hormoneAfterdischarge activityConnective nervesBag cellsSpike frequencyPotassium channel blocker tetraethylammoniumEffects of serotoninBag cell afterdischargeChannel blocker tetraethylammoniumDose-dependent mannerResult of serotoninPeptide hormone releaseNeuroendocrine bag cellsSerotonergic inhibitionSerotonin inhibitionSerotonergic synapsesSerotonergic inputBag cell neuronsHormone releaseIntracellular recordingsSerotonin receptorsBlocker tetraethylammoniumD-butaclamolAfterdischargesElectrical stimulation